Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity

Local translation meets protein turnover and plasticity demands at synapses, however, the location of its energy supply is unknown. We found that local translation in neurons is powered by mitochondria and not by glycolysis. Super-resolution microscopy revealed that dendritic mitochondria exist as s...

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Veröffentlicht in:	Cell 2019-01, Vol.176 (1-2), p.73-84.e15
Hauptverfasser:	Rangaraju, Vidhya, Lauterbach, Marcel, Schuman, Erin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP compartments cytoskeleton energy local translation mitochondria nascent protein protein synthesis synaptic plasticity
Online-Zugang:	Volltext
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