Management of hypothalamic disease in patients with craniopharyngioma
Summary Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic i...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2019-04, Vol.90 (4), p.506-516 |
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| container_title | Clinical endocrinology (Oxford) |
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| creator | Thompson, Christopher J. Costello, Richard W. Crowley, Rachel K. |
| description | Summary
Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. We present a practical, clinical approach to management of hypothalamic disease in a patient with craniopharyngioma and highlight potential targets for future pharmacological or surgical intervention. |
| doi_str_mv | 10.1111/cen.13929 |
| format | Article |
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Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. We present a practical, clinical approach to management of hypothalamic disease in a patient with craniopharyngioma and highlight potential targets for future pharmacological or surgical intervention.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.13929</identifier><identifier>PMID: 30614015</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>craniopharyngioma ; Disease management ; hypopituitarism ; Hypothalamus ; Morbidity ; Neoplasia ; Obesity ; Pathophysiology ; Pituitary ; Sleep ; Sleep disorders ; Thirst ; Tumors</subject><ispartof>Clinical endocrinology (Oxford), 2019-04, Vol.90 (4), p.506-516</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-c27b1b9e2d6a7641252d6586d70ae04928840d13fbf505e4ec2c0c4a2294794a3</citedby><cites>FETCH-LOGICAL-c3889-c27b1b9e2d6a7641252d6586d70ae04928840d13fbf505e4ec2c0c4a2294794a3</cites><orcidid>0000-0003-3688-8999 ; 0000-0003-1472-4117</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.13929$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.13929$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30614015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thompson, Christopher J.</creatorcontrib><creatorcontrib>Costello, Richard W.</creatorcontrib><creatorcontrib>Crowley, Rachel K.</creatorcontrib><title>Management of hypothalamic disease in patients with craniopharyngioma</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. We present a practical, clinical approach to management of hypothalamic disease in a patient with craniopharyngioma and highlight potential targets for future pharmacological or surgical intervention.</description><subject>craniopharyngioma</subject><subject>Disease management</subject><subject>hypopituitarism</subject><subject>Hypothalamus</subject><subject>Morbidity</subject><subject>Neoplasia</subject><subject>Obesity</subject><subject>Pathophysiology</subject><subject>Pituitary</subject><subject>Sleep</subject><subject>Sleep disorders</subject><subject>Thirst</subject><subject>Tumors</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10L1OwzAUBWALgWgpDLwAisQCQ9prx3biEVXlRyqwwBw5jtO4SuIQJ6r69hhSGJDwcj18Orr3IHSJYY79WyjdzHEkiDhCUxxxFhLC2TGaQgQQAud0gs6c2wIASyA-RZMIOKaA2RStnmUjN7rWTR_YIij3re1LWcnaqCA3TkunA9MEreyNJy7Ymb4MVCcbY9tSdvtmY2wtz9FJISunLw5zht7vV2_Lx3D9-vC0vFuHKkoSESoSZzgTmuRcxpxiwvyPJTyPQWqggiQJhRxHRVYwYJpqRRQoKgkRNBZURjN0M-a2nf0YtOvT2jilq0o22g4uJZhTRrnAsafXf-jWDl3jt_NKgCc4Try6HZXqrHOdLtK2M7W_K8WQfnWb-m7T7269vTokDlmt81_5U6YHixHsTKX3_yely9XLGPkJ-4KBcw</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Thompson, Christopher J.</creator><creator>Costello, Richard W.</creator><creator>Crowley, Rachel K.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3688-8999</orcidid><orcidid>https://orcid.org/0000-0003-1472-4117</orcidid></search><sort><creationdate>201904</creationdate><title>Management of hypothalamic disease in patients with craniopharyngioma</title><author>Thompson, Christopher J. ; Costello, Richard W. ; Crowley, Rachel K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-c27b1b9e2d6a7641252d6586d70ae04928840d13fbf505e4ec2c0c4a2294794a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>craniopharyngioma</topic><topic>Disease management</topic><topic>hypopituitarism</topic><topic>Hypothalamus</topic><topic>Morbidity</topic><topic>Neoplasia</topic><topic>Obesity</topic><topic>Pathophysiology</topic><topic>Pituitary</topic><topic>Sleep</topic><topic>Sleep disorders</topic><topic>Thirst</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, Christopher J.</creatorcontrib><creatorcontrib>Costello, Richard W.</creatorcontrib><creatorcontrib>Crowley, Rachel K.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, Christopher J.</au><au>Costello, Richard W.</au><au>Crowley, Rachel K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of hypothalamic disease in patients with craniopharyngioma</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2019-04</date><risdate>2019</risdate><volume>90</volume><issue>4</issue><spage>506</spage><epage>516</epage><pages>506-516</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Summary
Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. We present a practical, clinical approach to management of hypothalamic disease in a patient with craniopharyngioma and highlight potential targets for future pharmacological or surgical intervention.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30614015</pmid><doi>10.1111/cen.13929</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3688-8999</orcidid><orcidid>https://orcid.org/0000-0003-1472-4117</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2019-04, Vol.90 (4), p.506-516 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | craniopharyngioma Disease management hypopituitarism Hypothalamus Morbidity Neoplasia Obesity Pathophysiology Pituitary Sleep Sleep disorders Thirst Tumors |
| title | Management of hypothalamic disease in patients with craniopharyngioma |
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