Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation

Lymphocytes play a central role in the pathology of a range of chronic conditions such as autoimmune disease, transplant rejection, leukemia, lymphoma HIV/AIDs and cardiometabolic diseases such as atherosclerosis. Current treatments for lymphocyte-associated conditions are incompletely effective and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of controlled release 2019-02, Vol.296, p.29-39
Hauptverfasser:	Cao, Enyuan, Lindgren, Anna, Martinsson, Sofia, Hu, Luojuan, Lindfors, Lennart, Sigfridsson, Kalle, Skantze, Urban, Michaëlsson, Erik, Trevaskis, Natalie L., Porter, Christopher J.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Atherosclerosis ATP Binding Cassette Transporter 1 - genetics Drug targeting Female Forkhead Transcription Factors - genetics Gene Expression - drug effects Immunomodulation - drug effects Indazoles - administration & dosage Indazoles - blood Indazoles - pharmacokinetics Intestines - immunology Lipid based drug delivery system Lipophilic drugs Liver X Receptors - agonists Lymphatic transport Lymphatic Vessels - immunology Lymphocyte Lymphocytes - drug effects Lymphocytes - immunology Male Nanoparticles - administration & dosage Rats, Inbred Lew Rats, Sprague-Dawley T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!