Increased IL-17 and/or IFN-γ producing T-cell subsets in gut mucosa of long-term-treated HIV-1-infected women
OBJECTIVE:The influence of sex on gut mucosal T-cell response in HIV-1 infection remains largely unknown. We explored whether the frequencies of interferon-γ and/or IL-17 producing naive, T central memory and T effector memory (TEM) CD4 (Th1, Th17) and CD8 T (Tc1, Tc17) cells measured in gut and per...
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| Veröffentlicht in: | AIDS (London) 2019-03, Vol.33 (4), p.627-636 |
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| creator | d’Ettorre, Gabriella Borrazzo, Cristian Pinacchio, Claudia Santinelli, Letizia Cavallari, Eugenio N Statzu, Maura Fanello, Gianfranco Ceccarelli, Giancarlo Antonelli, Guido Vullo, Vincenzo Mastroianni, Claudio M Scagnolari, Carolina |
| description | OBJECTIVE:The influence of sex on gut mucosal T-cell response in HIV-1 infection remains largely unknown. We explored whether the frequencies of interferon-γ and/or IL-17 producing naive, T central memory and T effector memory (TEM) CD4 (Th1, Th17) and CD8 T (Tc1, Tc17) cells measured in gut and peripheral districts differed between female and male HIV-1-infected patients.
METHODS:Thirty long-term-treated HIV-1-infected individuals were enrolled. The frequencies of Th1, Th17, Tc1, Tc17-cell subsets (single and double) were evaluated by multiparametric flow cytometry in lamina propria lymphocytes and peripheral blood mononuclear cells (PBMC).
RESULTS:A sex-based pattern was recorded in the differences of Th1, Th17, Tc1, Tc17-cell subset (single and double) frequencies between gut and peripheral blood. Female patients had stronger alterations in the gut mucosal T-cell repertoire, especially increased Th1, Th17, and Th1/Th17-cell subset frequencies, compared with the blood district than their male counterparts. Higher naive Tc1, Tc17, Tc1/Tc17, TEM Tc17, and TEM Tc1/Tc17 levels were also recorded in the gut mucosa than in the PBMC of HIV-1-infected women. Males and females also differed in their gut T-cell response, with women being characterized by higher Th1, Th17, Tc1, Tc17, and Th1/Th17 cells subset levels than men. By contrast, only TEM Th1/Th17 and TEM Tc17 in PBMC differed between males and females.
CONCLUSION:Sex-based differences observed in the gut T-cell response of HIV-1-infected patients might contribute to the disease dimorphism. |
| doi_str_mv | 10.1097/QAD.0000000000002122 |
| format | Article |
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METHODS:Thirty long-term-treated HIV-1-infected individuals were enrolled. The frequencies of Th1, Th17, Tc1, Tc17-cell subsets (single and double) were evaluated by multiparametric flow cytometry in lamina propria lymphocytes and peripheral blood mononuclear cells (PBMC).
RESULTS:A sex-based pattern was recorded in the differences of Th1, Th17, Tc1, Tc17-cell subset (single and double) frequencies between gut and peripheral blood. Female patients had stronger alterations in the gut mucosal T-cell repertoire, especially increased Th1, Th17, and Th1/Th17-cell subset frequencies, compared with the blood district than their male counterparts. Higher naive Tc1, Tc17, Tc1/Tc17, TEM Tc17, and TEM Tc1/Tc17 levels were also recorded in the gut mucosa than in the PBMC of HIV-1-infected women. Males and females also differed in their gut T-cell response, with women being characterized by higher Th1, Th17, Tc1, Tc17, and Th1/Th17 cells subset levels than men. By contrast, only TEM Th1/Th17 and TEM Tc17 in PBMC differed between males and females.
CONCLUSION:Sex-based differences observed in the gut T-cell response of HIV-1-infected patients might contribute to the disease dimorphism.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000002122</identifier><identifier>PMID: 30608274</identifier><language>eng</language><publisher>England: Copyright Wolters Kluwer Health, Inc</publisher><subject>Adult ; AIDS/HIV ; Anti-HIV Agents - therapeutic use ; Female ; HIV Infections - drug therapy ; HIV Infections - pathology ; HIV Infections - virology ; HIV-1 - isolation & purification ; Humans ; Interferon-gamma - metabolism ; Interleukin-17 - metabolism ; Intestinal Mucosa - immunology ; Intestinal Mucosa - pathology ; Intraepithelial Lymphocytes - immunology ; Male ; Middle Aged ; Sex Factors ; T-Lymphocyte Subsets - immunology</subject><ispartof>AIDS (London), 2019-03, Vol.33 (4), p.627-636</ispartof><rights>Copyright © 2019 Wolters Kluwer Health, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3562-f7d673630f371f58d6ea308fc93f7b2115871ddfa3a50e72177dfbfa14e0d7573</citedby><cites>FETCH-LOGICAL-c3562-f7d673630f371f58d6ea308fc93f7b2115871ddfa3a50e72177dfbfa14e0d7573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30608274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>d’Ettorre, Gabriella</creatorcontrib><creatorcontrib>Borrazzo, Cristian</creatorcontrib><creatorcontrib>Pinacchio, Claudia</creatorcontrib><creatorcontrib>Santinelli, Letizia</creatorcontrib><creatorcontrib>Cavallari, Eugenio N</creatorcontrib><creatorcontrib>Statzu, Maura</creatorcontrib><creatorcontrib>Fanello, Gianfranco</creatorcontrib><creatorcontrib>Ceccarelli, Giancarlo</creatorcontrib><creatorcontrib>Antonelli, Guido</creatorcontrib><creatorcontrib>Vullo, Vincenzo</creatorcontrib><creatorcontrib>Mastroianni, Claudio M</creatorcontrib><creatorcontrib>Scagnolari, Carolina</creatorcontrib><title>Increased IL-17 and/or IFN-γ producing T-cell subsets in gut mucosa of long-term-treated HIV-1-infected women</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>OBJECTIVE:The influence of sex on gut mucosal T-cell response in HIV-1 infection remains largely unknown. We explored whether the frequencies of interferon-γ and/or IL-17 producing naive, T central memory and T effector memory (TEM) CD4 (Th1, Th17) and CD8 T (Tc1, Tc17) cells measured in gut and peripheral districts differed between female and male HIV-1-infected patients.
METHODS:Thirty long-term-treated HIV-1-infected individuals were enrolled. The frequencies of Th1, Th17, Tc1, Tc17-cell subsets (single and double) were evaluated by multiparametric flow cytometry in lamina propria lymphocytes and peripheral blood mononuclear cells (PBMC).
RESULTS:A sex-based pattern was recorded in the differences of Th1, Th17, Tc1, Tc17-cell subset (single and double) frequencies between gut and peripheral blood. Female patients had stronger alterations in the gut mucosal T-cell repertoire, especially increased Th1, Th17, and Th1/Th17-cell subset frequencies, compared with the blood district than their male counterparts. Higher naive Tc1, Tc17, Tc1/Tc17, TEM Tc17, and TEM Tc1/Tc17 levels were also recorded in the gut mucosa than in the PBMC of HIV-1-infected women. Males and females also differed in their gut T-cell response, with women being characterized by higher Th1, Th17, Tc1, Tc17, and Th1/Th17 cells subset levels than men. By contrast, only TEM Th1/Th17 and TEM Tc17 in PBMC differed between males and females.
CONCLUSION:Sex-based differences observed in the gut T-cell response of HIV-1-infected patients might contribute to the disease dimorphism.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Female</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - pathology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - isolation & purification</subject><subject>Humans</subject><subject>Interferon-gamma - metabolism</subject><subject>Interleukin-17 - metabolism</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intraepithelial Lymphocytes - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Sex Factors</subject><subject>T-Lymphocyte Subsets - immunology</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1Kw0AUhQdRtFbfQGSWbqadnySTLqVaGyiKUN2GaeZOG01m6kxC8bl8D5_JlFYRF97N5cI553I-hC4YHTA6ksPH65sB_TWccX6AeiySgsSxZIeoR3kyIiMh6Qk6DeGlE8U0TY_RiaAJTbmMeshmtvCgAmiczQiTWFk9dB5nk3vy-YHX3um2KO0Sz0kBVYVDuwjQBFxavGwbXLeFCwo7gytnl6QBX5Omy2u6vGn2TBgprYFie25cDfYMHRlVBTjf7z56mtzOx1Mye7jLxtczUog44cRInUiRCGqEZCZOdQJK0NQUI2HkgjMWp5JpbZRQMQXJmZTaLIxiEVAtYyn66GqX2xV4ayE0eV2GbQFlwbUh5yyJGBVbWH0U7aSFdyF4MPnal7Xy7zmj-ZZ03pHO_5LubJf7D-2iBv1j-kbbCdKdYOOqjkt4rdoN-HwFqmpW_2d_AasZiOs</recordid><startdate>20190315</startdate><enddate>20190315</enddate><creator>d’Ettorre, Gabriella</creator><creator>Borrazzo, Cristian</creator><creator>Pinacchio, Claudia</creator><creator>Santinelli, Letizia</creator><creator>Cavallari, Eugenio N</creator><creator>Statzu, Maura</creator><creator>Fanello, Gianfranco</creator><creator>Ceccarelli, Giancarlo</creator><creator>Antonelli, Guido</creator><creator>Vullo, Vincenzo</creator><creator>Mastroianni, Claudio M</creator><creator>Scagnolari, Carolina</creator><general>Copyright Wolters Kluwer Health, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190315</creationdate><title>Increased IL-17 and/or IFN-γ producing T-cell subsets in gut mucosa of long-term-treated HIV-1-infected women</title><author>d’Ettorre, Gabriella ; Borrazzo, Cristian ; Pinacchio, Claudia ; Santinelli, Letizia ; Cavallari, Eugenio N ; Statzu, Maura ; Fanello, Gianfranco ; Ceccarelli, Giancarlo ; Antonelli, Guido ; Vullo, Vincenzo ; Mastroianni, Claudio M ; Scagnolari, Carolina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3562-f7d673630f371f58d6ea308fc93f7b2115871ddfa3a50e72177dfbfa14e0d7573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Female</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - pathology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - isolation & purification</topic><topic>Humans</topic><topic>Interferon-gamma - metabolism</topic><topic>Interleukin-17 - metabolism</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intraepithelial Lymphocytes - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Sex Factors</topic><topic>T-Lymphocyte Subsets - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>d’Ettorre, Gabriella</creatorcontrib><creatorcontrib>Borrazzo, Cristian</creatorcontrib><creatorcontrib>Pinacchio, Claudia</creatorcontrib><creatorcontrib>Santinelli, Letizia</creatorcontrib><creatorcontrib>Cavallari, Eugenio N</creatorcontrib><creatorcontrib>Statzu, Maura</creatorcontrib><creatorcontrib>Fanello, Gianfranco</creatorcontrib><creatorcontrib>Ceccarelli, Giancarlo</creatorcontrib><creatorcontrib>Antonelli, Guido</creatorcontrib><creatorcontrib>Vullo, Vincenzo</creatorcontrib><creatorcontrib>Mastroianni, Claudio M</creatorcontrib><creatorcontrib>Scagnolari, Carolina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>d’Ettorre, Gabriella</au><au>Borrazzo, Cristian</au><au>Pinacchio, Claudia</au><au>Santinelli, Letizia</au><au>Cavallari, Eugenio N</au><au>Statzu, Maura</au><au>Fanello, Gianfranco</au><au>Ceccarelli, Giancarlo</au><au>Antonelli, Guido</au><au>Vullo, Vincenzo</au><au>Mastroianni, Claudio M</au><au>Scagnolari, Carolina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased IL-17 and/or IFN-γ producing T-cell subsets in gut mucosa of long-term-treated HIV-1-infected women</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2019-03-15</date><risdate>2019</risdate><volume>33</volume><issue>4</issue><spage>627</spage><epage>636</epage><pages>627-636</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>OBJECTIVE:The influence of sex on gut mucosal T-cell response in HIV-1 infection remains largely unknown. We explored whether the frequencies of interferon-γ and/or IL-17 producing naive, T central memory and T effector memory (TEM) CD4 (Th1, Th17) and CD8 T (Tc1, Tc17) cells measured in gut and peripheral districts differed between female and male HIV-1-infected patients.
METHODS:Thirty long-term-treated HIV-1-infected individuals were enrolled. The frequencies of Th1, Th17, Tc1, Tc17-cell subsets (single and double) were evaluated by multiparametric flow cytometry in lamina propria lymphocytes and peripheral blood mononuclear cells (PBMC).
RESULTS:A sex-based pattern was recorded in the differences of Th1, Th17, Tc1, Tc17-cell subset (single and double) frequencies between gut and peripheral blood. Female patients had stronger alterations in the gut mucosal T-cell repertoire, especially increased Th1, Th17, and Th1/Th17-cell subset frequencies, compared with the blood district than their male counterparts. Higher naive Tc1, Tc17, Tc1/Tc17, TEM Tc17, and TEM Tc1/Tc17 levels were also recorded in the gut mucosa than in the PBMC of HIV-1-infected women. Males and females also differed in their gut T-cell response, with women being characterized by higher Th1, Th17, Tc1, Tc17, and Th1/Th17 cells subset levels than men. By contrast, only TEM Th1/Th17 and TEM Tc17 in PBMC differed between males and females.
CONCLUSION:Sex-based differences observed in the gut T-cell response of HIV-1-infected patients might contribute to the disease dimorphism.</abstract><cop>England</cop><pub>Copyright Wolters Kluwer Health, Inc</pub><pmid>30608274</pmid><doi>10.1097/QAD.0000000000002122</doi><tpages>10</tpages></addata></record> |
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| ispartof | AIDS (London), 2019-03, Vol.33 (4), p.627-636 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult AIDS/HIV Anti-HIV Agents - therapeutic use Female HIV Infections - drug therapy HIV Infections - pathology HIV Infections - virology HIV-1 - isolation & purification Humans Interferon-gamma - metabolism Interleukin-17 - metabolism Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intraepithelial Lymphocytes - immunology Male Middle Aged Sex Factors T-Lymphocyte Subsets - immunology |
| title | Increased IL-17 and/or IFN-γ producing T-cell subsets in gut mucosa of long-term-treated HIV-1-infected women |
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