Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study
BACKGROUND Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries. STUDY DESIGN AND METHODS Twelve blood center membe...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2019-04, Vol.59 (4), p.1267-1272 |
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| creator | Goldman, Mindy Germain, Marc Grégoire, Yves Vassallo, Ralph R. Kamel, Hany Bravo, Marjorie Irving, David O. Di Angelantonio, Emanuele Steele, Whitney R. O'Brien, Sheila F. Flanagan, Peter Bell, Barbara AuBuchon, James P. Gorlin, Jed Sayers, Merlyn Shaz, Beth Ziman, Alyssa |
| description | BACKGROUND
Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries.
STUDY DESIGN AND METHODS
Twelve blood center members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative from four countries with no upper age limit for whole blood and double RBC donation (Canada, New Zealand, England, and the United States) or an upper age limit of 80 (Australia) provided 2016 data on donors and donations, deferral rates, and vasovagal reactions by donor age and sex. Donors under age 24 were included in the number of total donors and donations, but not in deferral and reaction rate comparisons.
RESULTS
Older donors accounted for 1.0% (New Zealand) to 4.3% (United States) of donors, and 1.5% (New Zealand) to 5.6% (United States) of donations; most were between ages 71 and 76. The deferral rate was higher in older compared to 24‐ to 70‐year‐old males, but very similar between older and younger females. In contrast, vasovagal reaction rates were either lower (male donors) or similar (female donor for reactions with loss of consciousness) in older compared to 24‐ to 70‐year‐old donors.
CONCLUSIONS
Exclusion solely based on older age appears to be unwarranted based on safety concerns such as donor reactions. Healthy older individuals can continue to safely donate and make a significant contribution to the blood supply past arbitrary age limits.
See article on page 1166–1170, in this issue |
| doi_str_mv | 10.1111/trf.15132 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2164101714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2164101714</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3882-e74e0bc658f1f57deaef1f494f8a9ddc1ee5ce350adfca079d53e8bd2c11db7e3</originalsourceid><addsrcrecordid>eNp1kc9q3DAQxkVoSLZJD3mBIuglPTjR2Jb_5NYuSRsIFJLtWcjSKFXwWo5kbfC79GGrzW56KFQgNAy_75tBHyFnwC4gncvJmwvgUOQHZAG8qLO8bfk7smCshAxS_5i8D-GJMZa3DI7IccEq1qa7IL8fpMFpps7QrndOU-0GOVk30G6mdtB2Y3WUfaBug57KR6Q1o3LQdPqF1lPlhsnbLr4qJrft7n1CHMd-a0GN3SDVuMHejaiTJG41GK6opF-vH1Z06fpeds6nuYl89C6ONExRz6fk0KTZ-GH_npCfN9er5ffs7se32-WXu0wVTZNnWJfIOlXxxoDhtUaJqSjb0jSy1VoBIldYcCa1UZLVreYFNp3OFYDuaixOyPnOd_TuOWKYxNoGhWmrAV0MIoeqBAY1lAn99A_65KIf0nYiz9P3VlVb8ER93lHKuxA8GjF6u5Z-FsDENjKRIhOvkSX2494xdmvUf8m3jBJwuQNebI_z_53E6v5mZ_kHc2yjAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2202966935</pqid></control><display><type>article</type><title>Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Goldman, Mindy ; Germain, Marc ; Grégoire, Yves ; Vassallo, Ralph R. ; Kamel, Hany ; Bravo, Marjorie ; Irving, David O. ; Di Angelantonio, Emanuele ; Steele, Whitney R. ; O'Brien, Sheila F. ; Flanagan, Peter ; Bell, Barbara ; AuBuchon, James P. ; Gorlin, Jed ; Sayers, Merlyn ; Shaz, Beth ; Ziman, Alyssa</creator><creatorcontrib>Goldman, Mindy ; Germain, Marc ; Grégoire, Yves ; Vassallo, Ralph R. ; Kamel, Hany ; Bravo, Marjorie ; Irving, David O. ; Di Angelantonio, Emanuele ; Steele, Whitney R. ; O'Brien, Sheila F. ; Flanagan, Peter ; Bell, Barbara ; AuBuchon, James P. ; Gorlin, Jed ; Sayers, Merlyn ; Shaz, Beth ; Ziman, Alyssa ; Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators ; for the Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators</creatorcontrib><description>BACKGROUND
Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries.
STUDY DESIGN AND METHODS
Twelve blood center members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative from four countries with no upper age limit for whole blood and double RBC donation (Canada, New Zealand, England, and the United States) or an upper age limit of 80 (Australia) provided 2016 data on donors and donations, deferral rates, and vasovagal reactions by donor age and sex. Donors under age 24 were included in the number of total donors and donations, but not in deferral and reaction rate comparisons.
RESULTS
Older donors accounted for 1.0% (New Zealand) to 4.3% (United States) of donors, and 1.5% (New Zealand) to 5.6% (United States) of donations; most were between ages 71 and 76. The deferral rate was higher in older compared to 24‐ to 70‐year‐old males, but very similar between older and younger females. In contrast, vasovagal reaction rates were either lower (male donors) or similar (female donor for reactions with loss of consciousness) in older compared to 24‐ to 70‐year‐old donors.
CONCLUSIONS
Exclusion solely based on older age appears to be unwarranted based on safety concerns such as donor reactions. Healthy older individuals can continue to safely donate and make a significant contribution to the blood supply past arbitrary age limits.
See article on page 1166–1170, in this issue</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.15132</identifier><identifier>PMID: 30609060</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Blood ; Blood & organ donations ; Blood Donors ; Blood Safety ; Collaboration ; Developed countries ; Female ; Females ; Humans ; Male ; Males ; Middle Aged ; Risk Factors ; Safety ; Syncope, Vasovagal - epidemiology ; Transfusion</subject><ispartof>Transfusion (Philadelphia, Pa.), 2019-04, Vol.59 (4), p.1267-1272</ispartof><rights>2019 AABB</rights><rights>2019 AABB.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-e74e0bc658f1f57deaef1f494f8a9ddc1ee5ce350adfca079d53e8bd2c11db7e3</citedby><cites>FETCH-LOGICAL-c3882-e74e0bc658f1f57deaef1f494f8a9ddc1ee5ce350adfca079d53e8bd2c11db7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.15132$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.15132$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30609060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldman, Mindy</creatorcontrib><creatorcontrib>Germain, Marc</creatorcontrib><creatorcontrib>Grégoire, Yves</creatorcontrib><creatorcontrib>Vassallo, Ralph R.</creatorcontrib><creatorcontrib>Kamel, Hany</creatorcontrib><creatorcontrib>Bravo, Marjorie</creatorcontrib><creatorcontrib>Irving, David O.</creatorcontrib><creatorcontrib>Di Angelantonio, Emanuele</creatorcontrib><creatorcontrib>Steele, Whitney R.</creatorcontrib><creatorcontrib>O'Brien, Sheila F.</creatorcontrib><creatorcontrib>Flanagan, Peter</creatorcontrib><creatorcontrib>Bell, Barbara</creatorcontrib><creatorcontrib>AuBuchon, James P.</creatorcontrib><creatorcontrib>Gorlin, Jed</creatorcontrib><creatorcontrib>Sayers, Merlyn</creatorcontrib><creatorcontrib>Shaz, Beth</creatorcontrib><creatorcontrib>Ziman, Alyssa</creatorcontrib><creatorcontrib>Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators</creatorcontrib><creatorcontrib>for the Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators</creatorcontrib><title>Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND
Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries.
STUDY DESIGN AND METHODS
Twelve blood center members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative from four countries with no upper age limit for whole blood and double RBC donation (Canada, New Zealand, England, and the United States) or an upper age limit of 80 (Australia) provided 2016 data on donors and donations, deferral rates, and vasovagal reactions by donor age and sex. Donors under age 24 were included in the number of total donors and donations, but not in deferral and reaction rate comparisons.
RESULTS
Older donors accounted for 1.0% (New Zealand) to 4.3% (United States) of donors, and 1.5% (New Zealand) to 5.6% (United States) of donations; most were between ages 71 and 76. The deferral rate was higher in older compared to 24‐ to 70‐year‐old males, but very similar between older and younger females. In contrast, vasovagal reaction rates were either lower (male donors) or similar (female donor for reactions with loss of consciousness) in older compared to 24‐ to 70‐year‐old donors.
CONCLUSIONS
Exclusion solely based on older age appears to be unwarranted based on safety concerns such as donor reactions. Healthy older individuals can continue to safely donate and make a significant contribution to the blood supply past arbitrary age limits.
See article on page 1166–1170, in this issue</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood Donors</subject><subject>Blood Safety</subject><subject>Collaboration</subject><subject>Developed countries</subject><subject>Female</subject><subject>Females</subject><subject>Humans</subject><subject>Male</subject><subject>Males</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Safety</subject><subject>Syncope, Vasovagal - epidemiology</subject><subject>Transfusion</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9q3DAQxkVoSLZJD3mBIuglPTjR2Jb_5NYuSRsIFJLtWcjSKFXwWo5kbfC79GGrzW56KFQgNAy_75tBHyFnwC4gncvJmwvgUOQHZAG8qLO8bfk7smCshAxS_5i8D-GJMZa3DI7IccEq1qa7IL8fpMFpps7QrndOU-0GOVk30G6mdtB2Y3WUfaBug57KR6Q1o3LQdPqF1lPlhsnbLr4qJrft7n1CHMd-a0GN3SDVuMHejaiTJG41GK6opF-vH1Z06fpeds6nuYl89C6ONExRz6fk0KTZ-GH_npCfN9er5ffs7se32-WXu0wVTZNnWJfIOlXxxoDhtUaJqSjb0jSy1VoBIldYcCa1UZLVreYFNp3OFYDuaixOyPnOd_TuOWKYxNoGhWmrAV0MIoeqBAY1lAn99A_65KIf0nYiz9P3VlVb8ER93lHKuxA8GjF6u5Z-FsDENjKRIhOvkSX2494xdmvUf8m3jBJwuQNebI_z_53E6v5mZ_kHc2yjAw</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Goldman, Mindy</creator><creator>Germain, Marc</creator><creator>Grégoire, Yves</creator><creator>Vassallo, Ralph R.</creator><creator>Kamel, Hany</creator><creator>Bravo, Marjorie</creator><creator>Irving, David O.</creator><creator>Di Angelantonio, Emanuele</creator><creator>Steele, Whitney R.</creator><creator>O'Brien, Sheila F.</creator><creator>Flanagan, Peter</creator><creator>Bell, Barbara</creator><creator>AuBuchon, James P.</creator><creator>Gorlin, Jed</creator><creator>Sayers, Merlyn</creator><creator>Shaz, Beth</creator><creator>Ziman, Alyssa</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201904</creationdate><title>Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study</title><author>Goldman, Mindy ; Germain, Marc ; Grégoire, Yves ; Vassallo, Ralph R. ; Kamel, Hany ; Bravo, Marjorie ; Irving, David O. ; Di Angelantonio, Emanuele ; Steele, Whitney R. ; O'Brien, Sheila F. ; Flanagan, Peter ; Bell, Barbara ; AuBuchon, James P. ; Gorlin, Jed ; Sayers, Merlyn ; Shaz, Beth ; Ziman, Alyssa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-e74e0bc658f1f57deaef1f494f8a9ddc1ee5ce350adfca079d53e8bd2c11db7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood Donors</topic><topic>Blood Safety</topic><topic>Collaboration</topic><topic>Developed countries</topic><topic>Female</topic><topic>Females</topic><topic>Humans</topic><topic>Male</topic><topic>Males</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Safety</topic><topic>Syncope, Vasovagal - epidemiology</topic><topic>Transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldman, Mindy</creatorcontrib><creatorcontrib>Germain, Marc</creatorcontrib><creatorcontrib>Grégoire, Yves</creatorcontrib><creatorcontrib>Vassallo, Ralph R.</creatorcontrib><creatorcontrib>Kamel, Hany</creatorcontrib><creatorcontrib>Bravo, Marjorie</creatorcontrib><creatorcontrib>Irving, David O.</creatorcontrib><creatorcontrib>Di Angelantonio, Emanuele</creatorcontrib><creatorcontrib>Steele, Whitney R.</creatorcontrib><creatorcontrib>O'Brien, Sheila F.</creatorcontrib><creatorcontrib>Flanagan, Peter</creatorcontrib><creatorcontrib>Bell, Barbara</creatorcontrib><creatorcontrib>AuBuchon, James P.</creatorcontrib><creatorcontrib>Gorlin, Jed</creatorcontrib><creatorcontrib>Sayers, Merlyn</creatorcontrib><creatorcontrib>Shaz, Beth</creatorcontrib><creatorcontrib>Ziman, Alyssa</creatorcontrib><creatorcontrib>Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators</creatorcontrib><creatorcontrib>for the Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldman, Mindy</au><au>Germain, Marc</au><au>Grégoire, Yves</au><au>Vassallo, Ralph R.</au><au>Kamel, Hany</au><au>Bravo, Marjorie</au><au>Irving, David O.</au><au>Di Angelantonio, Emanuele</au><au>Steele, Whitney R.</au><au>O'Brien, Sheila F.</au><au>Flanagan, Peter</au><au>Bell, Barbara</au><au>AuBuchon, James P.</au><au>Gorlin, Jed</au><au>Sayers, Merlyn</au><au>Shaz, Beth</au><au>Ziman, Alyssa</au><aucorp>Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators</aucorp><aucorp>for the Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2019-04</date><risdate>2019</risdate><volume>59</volume><issue>4</issue><spage>1267</spage><epage>1272</epage><pages>1267-1272</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>BACKGROUND
Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries.
STUDY DESIGN AND METHODS
Twelve blood center members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative from four countries with no upper age limit for whole blood and double RBC donation (Canada, New Zealand, England, and the United States) or an upper age limit of 80 (Australia) provided 2016 data on donors and donations, deferral rates, and vasovagal reactions by donor age and sex. Donors under age 24 were included in the number of total donors and donations, but not in deferral and reaction rate comparisons.
RESULTS
Older donors accounted for 1.0% (New Zealand) to 4.3% (United States) of donors, and 1.5% (New Zealand) to 5.6% (United States) of donations; most were between ages 71 and 76. The deferral rate was higher in older compared to 24‐ to 70‐year‐old males, but very similar between older and younger females. In contrast, vasovagal reaction rates were either lower (male donors) or similar (female donor for reactions with loss of consciousness) in older compared to 24‐ to 70‐year‐old donors.
CONCLUSIONS
Exclusion solely based on older age appears to be unwarranted based on safety concerns such as donor reactions. Healthy older individuals can continue to safely donate and make a significant contribution to the blood supply past arbitrary age limits.
See article on page 1166–1170, in this issue</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30609060</pmid><doi>10.1111/trf.15132</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transfusion (Philadelphia, Pa.), 2019-04, Vol.59 (4), p.1267-1272 |
| issn | 0041-1132 1537-2995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2164101714 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult Age Age Factors Aged Blood Blood & organ donations Blood Donors Blood Safety Collaboration Developed countries Female Females Humans Male Males Middle Aged Risk Factors Safety Syncope, Vasovagal - epidemiology Transfusion |
| title | Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study |
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