Nox4 and soluble epoxide hydrolase synergistically mediate homocysteine-induced inflammation in vascular smooth muscle cells

Hyperhomocysteinemia leads to a vascular smooth muscle cell (VSMC) inflammatory response. Meanwhile, Nox4 dependent reactive oxygen species (ROS) signaling and soluble epoxide hydrolase (sEH)/epoxyeicosatrienoic acids (EETs) are both involved in vascular inflammation. Herein, we hypothesized that No...

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Veröffentlicht in:	Vascular pharmacology 2019-09, Vol.120, p.106544-106544, Article 106544
Hauptverfasser:	Liu, Xi, Qin, Zhexue, Liu, Chuan, Song, Mingbao, Luo, Xiaolin, Zhao, Hongqing, Qian, Dehui, Chen, Jianfei, Huang, Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Disease Models, Animal Enzyme-linked immunosorbent assay Epoxide hydrolase Epoxide Hydrolases - metabolism Homocysteine Hyperhomocysteinemia Hyperhomocysteinemia - complications Hyperhomocysteinemia - enzymology Hyperhomocysteinemia - pathology Inflammation Inflammatory response Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Male Mice, Inbred C57BL mRNA Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Muscles Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology NADPH Oxidase 4 - metabolism Nox4 NOX4 protein Organic chemistry Oxidative Stress Rats Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction siRNA Smooth muscle Soluble epoxide hydrolase Staphylococcal enterotoxin H Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism Vascular inflammation Vasculitis - enzymology Vasculitis - etiology Vasculitis - pathology Western blotting
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