Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans
A hepatokine is a collective term for liver-derived secretory factors whose previously-unrecognized functions have been recently elucidated. We have rediscovered selenoprotein P (SeP) and leukocyte cell-derived chemotaxin 2 (LECT2) as hepatokines that are involved in the development of insulin resis...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2019/03/01, Vol.42(3), pp.373-378 |
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| creator | Mohri, Kensuke Misu, Hirofumi Takayama, Hiroaki Ishii, Kiyo-aki Kikuchi, Akihiro Lan, Fei Enyama, Yasufumi Takeshita, Yumie Saito, Yoshiro Kaneko, Shuichi Takamura, Toshinari |
| description | A hepatokine is a collective term for liver-derived secretory factors whose previously-unrecognized functions have been recently elucidated. We have rediscovered selenoprotein P (SeP) and leukocyte cell-derived chemotaxin 2 (LECT2) as hepatokines that are involved in the development of insulin resistance and hyperglycemia. The aim of this study was to determine whether and, if so, how oral glucose loading alters the two hepatokines in humans. We measured concentrations of serum SeP and plasma LECT2 during 75 g oral glucose tolerance test (OGTT) (n = 20) in people with various degrees of glucose tolerance. In OGTT, concentrations of both serum SeP and plasma LECT2 decreased at 120 min compared with the baseline values, irrespective of the severity of glucose intolerance. Decrement of serum SeP during OGTT showed no correlations to the clinical parameters associated with insulin resistance or insulin secretion. In multiple stepwise regression analyses, plasma cortisol was selected as the variable to explain the changes in plasma concentrations of LECT2. The current data reveal the acute inhibitory actions of oral intake of glucose on circulating SeP and LECT2 in humans, irrespective of the severity of glucose intolerance. This study suggests that circulating SeP is regulated by the unknown clinical factors other than insulin and glucose during OGTT. |
| doi_str_mv | 10.1248/bpb.b18-00549 |
| format | Article |
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We have rediscovered selenoprotein P (SeP) and leukocyte cell-derived chemotaxin 2 (LECT2) as hepatokines that are involved in the development of insulin resistance and hyperglycemia. The aim of this study was to determine whether and, if so, how oral glucose loading alters the two hepatokines in humans. We measured concentrations of serum SeP and plasma LECT2 during 75 g oral glucose tolerance test (OGTT) (n = 20) in people with various degrees of glucose tolerance. In OGTT, concentrations of both serum SeP and plasma LECT2 decreased at 120 min compared with the baseline values, irrespective of the severity of glucose intolerance. Decrement of serum SeP during OGTT showed no correlations to the clinical parameters associated with insulin resistance or insulin secretion. In multiple stepwise regression analyses, plasma cortisol was selected as the variable to explain the changes in plasma concentrations of LECT2. The current data reveal the acute inhibitory actions of oral intake of glucose on circulating SeP and LECT2 in humans, irrespective of the severity of glucose intolerance. This study suggests that circulating SeP is regulated by the unknown clinical factors other than insulin and glucose during OGTT.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b18-00549</identifier><identifier>PMID: 30606895</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Chromium ; Cortisol ; Glucose ; Glucose tolerance ; hepatokine ; Hyperglycemia ; Insulin ; Insulin resistance ; Insulin secretion ; Intolerance ; leukocyte cell-derived chemotaxin 2 ; oral glucose tolerance test ; Secretion ; selenoprotein P</subject><ispartof>Biological and Pharmaceutical Bulletin, 2019/03/01, Vol.42(3), pp.373-378</ispartof><rights>2019 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c658t-f6f760e6a162c2dba5ff903d46fe67b4ab9ee880fd5b21f0d2ac69dbe177d09f3</citedby><cites>FETCH-LOGICAL-c658t-f6f760e6a162c2dba5ff903d46fe67b4ab9ee880fd5b21f0d2ac69dbe177d09f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30606895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohri, Kensuke</creatorcontrib><creatorcontrib>Misu, Hirofumi</creatorcontrib><creatorcontrib>Takayama, Hiroaki</creatorcontrib><creatorcontrib>Ishii, Kiyo-aki</creatorcontrib><creatorcontrib>Kikuchi, Akihiro</creatorcontrib><creatorcontrib>Lan, Fei</creatorcontrib><creatorcontrib>Enyama, Yasufumi</creatorcontrib><creatorcontrib>Takeshita, Yumie</creatorcontrib><creatorcontrib>Saito, Yoshiro</creatorcontrib><creatorcontrib>Kaneko, Shuichi</creatorcontrib><creatorcontrib>Takamura, Toshinari</creatorcontrib><creatorcontrib>bDepartment of System Biology</creatorcontrib><creatorcontrib>dDepartment of Endocrinology and Metabolism</creatorcontrib><creatorcontrib>eLaboratory of Molecular and Biochemical Toxicology</creatorcontrib><creatorcontrib>Graduate School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Kanazawa University Graduate School of Medical Sciences</creatorcontrib><creatorcontrib>Japan Science and Technology Agency</creatorcontrib><creatorcontrib>Chengdu First People's Hospital</creatorcontrib><creatorcontrib>Doshisha University</creatorcontrib><creatorcontrib>aDepartment of Endocrinology and Metabolism</creatorcontrib><creatorcontrib>Faculty of Life and Medical Sciences</creatorcontrib><creatorcontrib>Tohoku University</creatorcontrib><creatorcontrib>cPRESTO</creatorcontrib><creatorcontrib>fDepartment of Medical Life Systems</creatorcontrib><title>Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>A hepatokine is a collective term for liver-derived secretory factors whose previously-unrecognized functions have been recently elucidated. 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The current data reveal the acute inhibitory actions of oral intake of glucose on circulating SeP and LECT2 in humans, irrespective of the severity of glucose intolerance. This study suggests that circulating SeP is regulated by the unknown clinical factors other than insulin and glucose during OGTT.</description><subject>Chromium</subject><subject>Cortisol</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>hepatokine</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin secretion</subject><subject>Intolerance</subject><subject>leukocyte cell-derived chemotaxin 2</subject><subject>oral glucose tolerance test</subject><subject>Secretion</subject><subject>selenoprotein P</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkUFv1DAQhSMEokvhyBVZ4sKhKWMncZJjlcK20kpFsJwtx5m03nrtxU4Q_Vn8Q2a7ZZGQrLGs-fzmjV6WveVwzkXZfOx3_XnPmxygKttn2YIXZZ1XglfPswW01JC8ak6yVyltAKAGUbzMTgqQIJu2WmS_OxvN7PRk_S3rgjfop0iv4BMLI7v2aXbWs6-YbJo0tfOLlIKxesKBXeFOT-Heekxn7Bs69GEXw4T04QvTfmArnO-DeZiQdehcfonR_qR_3R1uw6R_ESfO2DDH_XDt2U3Uji3dbEJCtg4O434iW2OaGLFX81b79Dp7MWqX8M3TfZp9__xp3V3lq5vldXexyo2smikf5VhLQKm5FEYMva7GsYViKOWIsu5L3beITQPjUPWCjzAIbWQ79MjreoB2LE6zDwddWunHTBbU1iZDa2iPYU5KcFlygKZuCX3_H7oJc_TkTglR0gFZCKLyA2ViSCniqHbRbnV8UBzUPktFWSrKUj1mSfy7J9W53-JwpP-GR8DyAFDXGu2Cp6jw32yT6t4GF5QA3pJoKaBQwIWCoi72pSFXFZC506w7KG0o5Fs8jtJxssbho7FSqGJfjgaPXXOno0Jf_AF1Asvk</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Mohri, Kensuke</creator><creator>Misu, Hirofumi</creator><creator>Takayama, Hiroaki</creator><creator>Ishii, Kiyo-aki</creator><creator>Kikuchi, Akihiro</creator><creator>Lan, Fei</creator><creator>Enyama, Yasufumi</creator><creator>Takeshita, Yumie</creator><creator>Saito, Yoshiro</creator><creator>Kaneko, Shuichi</creator><creator>Takamura, Toshinari</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20190301</creationdate><title>Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans</title><author>Mohri, Kensuke ; 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| subjects | Chromium Cortisol Glucose Glucose tolerance hepatokine Hyperglycemia Insulin Insulin resistance Insulin secretion Intolerance leukocyte cell-derived chemotaxin 2 oral glucose tolerance test Secretion selenoprotein P |
| title | Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans |
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