Is the Oil | Water Interface the Simplest and Best Suited Model for Understanding Biomembranes?
Many studies have been conducted by using the oil (O) | water (W) interface as a simple model for understanding ion transfer (IT) or electron transfer (ET) across biomembranes. In this review, we revisit the usability of the O | W interface as a biomembrane model. For understanding biomembrane IT, t...
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| Veröffentlicht in: | Analytical Sciences 2019/04/10, Vol.35(4), pp.361-366 |
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| creator | OSAKAI, Toshiyuki |
| description | Many studies have been conducted by using the oil (O) | water (W) interface as a simple model for understanding ion transfer (IT) or electron transfer (ET) across biomembranes. In this review, we revisit the usability of the O | W interface as a biomembrane model. For understanding biomembrane IT, the O | W interface is the simplest and best suited model. For example, the standard Gibbs transfer energy of drug ions at the O | W interface is a useful measure for evaluating their membrane permeability in a conventional in vitro assay, called PAMPA. However, the O | W interface is not necessarily a good model for understanding biomembrane ET. This is because no net current can be observed with the O | W interface, owing to the ET-coupled proton transfer. In such a case, the self-assembled monolayer (SAM) formed on a metal electrode serves as a better model for understanding biomembrane ET. |
| doi_str_mv | 10.2116/analsci.18R005 |
| format | Article |
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In this review, we revisit the usability of the O | W interface as a biomembrane model. For understanding biomembrane IT, the O | W interface is the simplest and best suited model. For example, the standard Gibbs transfer energy of drug ions at the O | W interface is a useful measure for evaluating their membrane permeability in a conventional in vitro assay, called PAMPA. However, the O | W interface is not necessarily a good model for understanding biomembrane ET. This is because no net current can be observed with the O | W interface, owing to the ET-coupled proton transfer. In such a case, the self-assembled monolayer (SAM) formed on a metal electrode serves as a better model for understanding biomembrane ET.</description><identifier>ISSN: 0910-6340</identifier><identifier>EISSN: 1348-2246</identifier><identifier>DOI: 10.2116/analsci.18R005</identifier><identifier>PMID: 30606904</identifier><language>eng</language><publisher>Japan: The Japan Society for Analytical Chemistry</publisher><subject>biomembrane model ; Electrodes ; Electron transfer ; Electron Transport ; Humans ; ion transfer ; Membrane Lipids - chemistry ; Membrane permeability ; Mud-water interfaces ; non-Bornian model ; Oil | water interface ; Oils - chemistry ; self-assembled monolayer ; Self-assembled monolayers ; Self-assembly ; Voice communication ; Water - chemistry</subject><ispartof>Analytical Sciences, 2019/04/10, Vol.35(4), pp.361-366</ispartof><rights>2019 by The Japan Society for Analytical Chemistry</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30606904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OSAKAI, Toshiyuki</creatorcontrib><title>Is the Oil | Water Interface the Simplest and Best Suited Model for Understanding Biomembranes?</title><title>Analytical Sciences</title><addtitle>Anal Sci</addtitle><description>Many studies have been conducted by using the oil (O) | water (W) interface as a simple model for understanding ion transfer (IT) or electron transfer (ET) across biomembranes. In this review, we revisit the usability of the O | W interface as a biomembrane model. For understanding biomembrane IT, the O | W interface is the simplest and best suited model. For example, the standard Gibbs transfer energy of drug ions at the O | W interface is a useful measure for evaluating their membrane permeability in a conventional in vitro assay, called PAMPA. However, the O | W interface is not necessarily a good model for understanding biomembrane ET. This is because no net current can be observed with the O | W interface, owing to the ET-coupled proton transfer. In such a case, the self-assembled monolayer (SAM) formed on a metal electrode serves as a better model for understanding biomembrane ET.</description><subject>biomembrane model</subject><subject>Electrodes</subject><subject>Electron transfer</subject><subject>Electron Transport</subject><subject>Humans</subject><subject>ion transfer</subject><subject>Membrane Lipids - chemistry</subject><subject>Membrane permeability</subject><subject>Mud-water interfaces</subject><subject>non-Bornian model</subject><subject>Oil | water interface</subject><subject>Oils - chemistry</subject><subject>self-assembled monolayer</subject><subject>Self-assembled monolayers</subject><subject>Self-assembly</subject><subject>Voice communication</subject><subject>Water - chemistry</subject><issn>0910-6340</issn><issn>1348-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctLxDAQxoMouj6uHiXgxUt18mjansS3C4rgA48hbaaapY81aQ-Cf7xZd_XgZeaD78fwzQwh-wyOOWPqxHSmCZU7ZvkjQLpGJkzIPOFcqnUygYJBooSELbIdwgyA8ZzzTbIlQIEqQE6IngY6vCN9cA39oq9mQE-nXay1qfDHeXLtvMEwUNNZer4QT6Mb0NL73mJD697Tl86iD0MEXPdGz13fYlt602E43SUbdUyIe6u-Q16ur54vbpO7h5vpxdldMhNSDEkGZSEtzwpVpgCmKpU1WarqoigsslJEjTWvRWVZxjPIbZkVkNZoGWSVVaXYIUfLuXPff4wxpW5dqLBpYop-DJozJRmA4jKih__QWT_6xR015wJyDnm-oA5W1Fi2aPXcu9b4T_17ughcLoFZ3PwN_wDjB1c1qFef0SLVclGWH_qzq3fjNXbiG_dCiJo</recordid><startdate>20190410</startdate><enddate>20190410</enddate><creator>OSAKAI, Toshiyuki</creator><general>The Japan Society for Analytical Chemistry</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20190410</creationdate><title>Is the Oil | Water Interface the Simplest and Best Suited Model for Understanding Biomembranes?</title><author>OSAKAI, Toshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j343t-70b94d2796b500acb6da756f999de1b3756ef2f3cd172708db7905fed107cd6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>biomembrane model</topic><topic>Electrodes</topic><topic>Electron transfer</topic><topic>Electron Transport</topic><topic>Humans</topic><topic>ion transfer</topic><topic>Membrane Lipids - chemistry</topic><topic>Membrane permeability</topic><topic>Mud-water interfaces</topic><topic>non-Bornian model</topic><topic>Oil | water interface</topic><topic>Oils - chemistry</topic><topic>self-assembled monolayer</topic><topic>Self-assembled monolayers</topic><topic>Self-assembly</topic><topic>Voice communication</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OSAKAI, Toshiyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OSAKAI, Toshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is the Oil | Water Interface the Simplest and Best Suited Model for Understanding Biomembranes?</atitle><jtitle>Analytical Sciences</jtitle><addtitle>Anal Sci</addtitle><date>2019-04-10</date><risdate>2019</risdate><volume>35</volume><issue>4</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0910-6340</issn><eissn>1348-2246</eissn><abstract>Many studies have been conducted by using the oil (O) | water (W) interface as a simple model for understanding ion transfer (IT) or electron transfer (ET) across biomembranes. 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| language | eng |
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| source | J-STAGE Free; MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry; SpringerLink Journals - AutoHoldings |
| subjects | biomembrane model Electrodes Electron transfer Electron Transport Humans ion transfer Membrane Lipids - chemistry Membrane permeability Mud-water interfaces non-Bornian model Oil | water interface Oils - chemistry self-assembled monolayer Self-assembled monolayers Self-assembly Voice communication Water - chemistry |
| title | Is the Oil | Water Interface the Simplest and Best Suited Model for Understanding Biomembranes? |
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