Amine-functionalized, porous silica-coated NaYF4:Yb/Er upconversion nanophosphors for efficient delivery of doxorubicin and curcumin
Upconversion nanoparticles (UCNP) with unique multi-photon excitation photo-luminescence properties have been extensively explored as novel contrast agents for low-background biomedical imaging. There is an increasing interest in employing UCNPs as carrier for drug delivery as these offers a unique...
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| Veröffentlicht in: | Materials Science & Engineering C 2019-03, Vol.96, p.86-95 |
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| creator | Reddy, Kumbam Lingeshwar Sharma, Peeyush Kumar Singh, Ashutosh Kumar, Ajay Shankar, Konathala Ravi Singh, Yashveer Garg, Neha Krishnan, Venkata |
| description | Upconversion nanoparticles (UCNP) with unique multi-photon excitation photo-luminescence properties have been extensively explored as novel contrast agents for low-background biomedical imaging. There is an increasing interest in employing UCNPs as carrier for drug delivery as these offers a unique opportunity to combine therapy and diagnostics in one platform (theranostics). In the present work, we report microwave-assisted synthesis of hexagonal NaYF4:Yb/Er UCNPs coated with porous silica and functionalized with amine (UCNP@mSiO2). The UCNP@mSiO2 were investigated for controlled delivery of a chemotherapeutic agent, doxorubicin (DOX, hydrophilic), and a chemosensitizing agent, curcumin (CCM, hydrophobic). The drug loading was relatively higher for DOX (17.4%), in comparison to CCM (8.1%). The cumulative drug release from DOX-loaded UCNP@mSiO2 were 30 and 41% at physiological (7.4) and tumoral (6.4) pH, following a pseudo Fickian release pattern, whereas the release from CCM-loaded UCNP@mSiO2 were 27 and 50% at pH 7.4 and 6.4, following a non-Fickian and pseudo-Fickian release patterns, respectively. Both DOX and CCM-loaded UCNP@mSiO2 exhibited pH-dependent controlled drug delivery but the effect was more pronounced for CCM, the hydrophobic chemosensitizer. Cell viability assay using HeLa cells showed that DOX-loaded UCNP@mSiO2 inhibit cell growth in a dose-dependent manner, similar to free DOX, but the cell inhibition activity of free CCM was lower than CCM passively entrapped in UCNP@mSiO2. Confocal microscopy studies revealed cell uptake of both the drug by HeLa cells. Thus, UCNP@mSiO2 exhibited the unique capability to deliver hydrophilic and hydrophobic drugs, individually. UCNP@mSiO2 carrier, equipped with theranostic capabilities, may potentially be used for pH-responsive release of chemotherapeutic agents in cancer environment.
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•Microwave-assisted synthesis of hexagonal NaYF4:Yb/Er UCNPs coated with porous silica•UCNP@mSiO2 were tested for controlled delivery of chemotherapeutic agent, doxorubicin and chemosensitizing agent, curcumin•Confocal microscopy studies revealed cell uptake of both the drug by HeLa cells•UCNP@mSiO2 exhibited the unique capability to deliver hydrophilic and hydrophobic drugs |
| doi_str_mv | 10.1016/j.msec.2018.11.007 |
| format | Article |
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[Display omitted]
•Microwave-assisted synthesis of hexagonal NaYF4:Yb/Er UCNPs coated with porous silica•UCNP@mSiO2 were tested for controlled delivery of chemotherapeutic agent, doxorubicin and chemosensitizing agent, curcumin•Confocal microscopy studies revealed cell uptake of both the drug by HeLa cells•UCNP@mSiO2 exhibited the unique capability to deliver hydrophilic and hydrophobic drugs</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2018.11.007</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Cancer ; Chemotherapy ; Confocal microscopy ; Contrast agents ; Curcumin ; Doxorubicin ; Drug delivery ; Drug delivery systems ; Erbium ; Fluorides ; Hydrophilicity ; Hydrophobicity ; Luminescence ; Materials science ; Medical imaging ; Microscopy ; Nanoparticles ; Nanophosphors ; Optical properties ; pH effects ; Photoluminescence ; Porous silica ; Precision medicine ; Silica ; Silicon dioxide ; Sodium compounds ; Upconversion ; Upconversion nanoparticles ; Ytterbium</subject><ispartof>Materials Science & Engineering C, 2019-03, Vol.96, p.86-95</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright Elsevier BV Mar 2019</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c291t-733d706ca58e8996d8b4dddc7361d717f7a0876b109b97f162c12527ae1fe4b13</citedby><cites>FETCH-LOGICAL-c291t-733d706ca58e8996d8b4dddc7361d717f7a0876b109b97f162c12527ae1fe4b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2018.11.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Reddy, Kumbam Lingeshwar</creatorcontrib><creatorcontrib>Sharma, Peeyush Kumar</creatorcontrib><creatorcontrib>Singh, Ashutosh</creatorcontrib><creatorcontrib>Kumar, Ajay</creatorcontrib><creatorcontrib>Shankar, Konathala Ravi</creatorcontrib><creatorcontrib>Singh, Yashveer</creatorcontrib><creatorcontrib>Garg, Neha</creatorcontrib><creatorcontrib>Krishnan, Venkata</creatorcontrib><title>Amine-functionalized, porous silica-coated NaYF4:Yb/Er upconversion nanophosphors for efficient delivery of doxorubicin and curcumin</title><title>Materials Science & Engineering C</title><description>Upconversion nanoparticles (UCNP) with unique multi-photon excitation photo-luminescence properties have been extensively explored as novel contrast agents for low-background biomedical imaging. There is an increasing interest in employing UCNPs as carrier for drug delivery as these offers a unique opportunity to combine therapy and diagnostics in one platform (theranostics). In the present work, we report microwave-assisted synthesis of hexagonal NaYF4:Yb/Er UCNPs coated with porous silica and functionalized with amine (UCNP@mSiO2). The UCNP@mSiO2 were investigated for controlled delivery of a chemotherapeutic agent, doxorubicin (DOX, hydrophilic), and a chemosensitizing agent, curcumin (CCM, hydrophobic). The drug loading was relatively higher for DOX (17.4%), in comparison to CCM (8.1%). The cumulative drug release from DOX-loaded UCNP@mSiO2 were 30 and 41% at physiological (7.4) and tumoral (6.4) pH, following a pseudo Fickian release pattern, whereas the release from CCM-loaded UCNP@mSiO2 were 27 and 50% at pH 7.4 and 6.4, following a non-Fickian and pseudo-Fickian release patterns, respectively. Both DOX and CCM-loaded UCNP@mSiO2 exhibited pH-dependent controlled drug delivery but the effect was more pronounced for CCM, the hydrophobic chemosensitizer. Cell viability assay using HeLa cells showed that DOX-loaded UCNP@mSiO2 inhibit cell growth in a dose-dependent manner, similar to free DOX, but the cell inhibition activity of free CCM was lower than CCM passively entrapped in UCNP@mSiO2. Confocal microscopy studies revealed cell uptake of both the drug by HeLa cells. Thus, UCNP@mSiO2 exhibited the unique capability to deliver hydrophilic and hydrophobic drugs, individually. UCNP@mSiO2 carrier, equipped with theranostic capabilities, may potentially be used for pH-responsive release of chemotherapeutic agents in cancer environment.
[Display omitted]
•Microwave-assisted synthesis of hexagonal NaYF4:Yb/Er UCNPs coated with porous silica•UCNP@mSiO2 were tested for controlled delivery of chemotherapeutic agent, doxorubicin and chemosensitizing agent, curcumin•Confocal microscopy studies revealed cell uptake of both the drug by HeLa cells•UCNP@mSiO2 exhibited the unique capability to deliver hydrophilic and hydrophobic drugs</description><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Confocal microscopy</subject><subject>Contrast agents</subject><subject>Curcumin</subject><subject>Doxorubicin</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Erbium</subject><subject>Fluorides</subject><subject>Hydrophilicity</subject><subject>Hydrophobicity</subject><subject>Luminescence</subject><subject>Materials science</subject><subject>Medical imaging</subject><subject>Microscopy</subject><subject>Nanoparticles</subject><subject>Nanophosphors</subject><subject>Optical properties</subject><subject>pH effects</subject><subject>Photoluminescence</subject><subject>Porous silica</subject><subject>Precision medicine</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Sodium compounds</subject><subject>Upconversion</subject><subject>Upconversion nanoparticles</subject><subject>Ytterbium</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kT9vFDEQxVcIJI7AF6CyREPBbjzePf9BNFGUEKQIGihSWV57LHzasxd7N0qo-eB4dVQUKUZTzO_N6M1rmrdAO6DAzw_dsaDtGAXZAXSUimfNDqToWwoKnjc7qphsB9XDy-ZVKQdKuewF2zV_Lo4hYuvXaJeQopnCb3QfyJxyWgspYQrWtDaZBR35au6uh4934_lVJutsU7zHXKqIRBPT_DOVWrkQnzJB74MNGBficAqVeyTJE5ceUl7HOonEREfsmu1a779uXngzFXzzr581P66vvl_etLffPn-5vLhtLVOwtKLvnaDcmr1EqRR3chycc1b0HJwA4YWhUvARqBqV8MCZBbZnwiB4HEboz5r3p71zTr9WLIs-hmJxmkzEalcz4ANQOsgNffcfekhrrv_ZKEnlwPaKV4qdKJtTKRm9nnM4mvyogeotGH3QWzB6C0YD6BpMFX06ibBavQ-YddleZdGFjHbRLoWn5H8BYH-YoA</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Reddy, Kumbam Lingeshwar</creator><creator>Sharma, Peeyush Kumar</creator><creator>Singh, Ashutosh</creator><creator>Kumar, Ajay</creator><creator>Shankar, Konathala Ravi</creator><creator>Singh, Yashveer</creator><creator>Garg, Neha</creator><creator>Krishnan, Venkata</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201903</creationdate><title>Amine-functionalized, porous silica-coated NaYF4:Yb/Er upconversion nanophosphors for efficient delivery of doxorubicin and curcumin</title><author>Reddy, Kumbam Lingeshwar ; 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There is an increasing interest in employing UCNPs as carrier for drug delivery as these offers a unique opportunity to combine therapy and diagnostics in one platform (theranostics). In the present work, we report microwave-assisted synthesis of hexagonal NaYF4:Yb/Er UCNPs coated with porous silica and functionalized with amine (UCNP@mSiO2). The UCNP@mSiO2 were investigated for controlled delivery of a chemotherapeutic agent, doxorubicin (DOX, hydrophilic), and a chemosensitizing agent, curcumin (CCM, hydrophobic). The drug loading was relatively higher for DOX (17.4%), in comparison to CCM (8.1%). The cumulative drug release from DOX-loaded UCNP@mSiO2 were 30 and 41% at physiological (7.4) and tumoral (6.4) pH, following a pseudo Fickian release pattern, whereas the release from CCM-loaded UCNP@mSiO2 were 27 and 50% at pH 7.4 and 6.4, following a non-Fickian and pseudo-Fickian release patterns, respectively. Both DOX and CCM-loaded UCNP@mSiO2 exhibited pH-dependent controlled drug delivery but the effect was more pronounced for CCM, the hydrophobic chemosensitizer. Cell viability assay using HeLa cells showed that DOX-loaded UCNP@mSiO2 inhibit cell growth in a dose-dependent manner, similar to free DOX, but the cell inhibition activity of free CCM was lower than CCM passively entrapped in UCNP@mSiO2. Confocal microscopy studies revealed cell uptake of both the drug by HeLa cells. Thus, UCNP@mSiO2 exhibited the unique capability to deliver hydrophilic and hydrophobic drugs, individually. UCNP@mSiO2 carrier, equipped with theranostic capabilities, may potentially be used for pH-responsive release of chemotherapeutic agents in cancer environment.
[Display omitted]
•Microwave-assisted synthesis of hexagonal NaYF4:Yb/Er UCNPs coated with porous silica•UCNP@mSiO2 were tested for controlled delivery of chemotherapeutic agent, doxorubicin and chemosensitizing agent, curcumin•Confocal microscopy studies revealed cell uptake of both the drug by HeLa cells•UCNP@mSiO2 exhibited the unique capability to deliver hydrophilic and hydrophobic drugs</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.msec.2018.11.007</doi><tpages>10</tpages></addata></record> |
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| subjects | Cancer Chemotherapy Confocal microscopy Contrast agents Curcumin Doxorubicin Drug delivery Drug delivery systems Erbium Fluorides Hydrophilicity Hydrophobicity Luminescence Materials science Medical imaging Microscopy Nanoparticles Nanophosphors Optical properties pH effects Photoluminescence Porous silica Precision medicine Silica Silicon dioxide Sodium compounds Upconversion Upconversion nanoparticles Ytterbium |
| title | Amine-functionalized, porous silica-coated NaYF4:Yb/Er upconversion nanophosphors for efficient delivery of doxorubicin and curcumin |
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