Polyarginine Peptides As a New Class of Ligands of Nicotinic Acetylcholine Receptors

Arginine-containing peptides R3, R8, and R16 were obtained by solid-phase peptide synthesis, and their binding to nicotinic acetylcholine receptors (nAChRs) of muscle and neuronal (α7) types was studied by competitive radioligand assay with the use of 125 I-α-bungarotoxin. The resulting peptides exh...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2018-11, Vol.483 (1), p.313-315
Hauptverfasser:	Kryukova, E. V., Ivanov, I. A., Lebedev, D. S., Spirova, E. N., Senko, D. A., Egorova, N. S., Kasheverov, I. E., Tsetlin, V. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Affinity alpha7 Nicotinic Acetylcholine Receptor - chemistry Amino acids Animals Arginine Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Bungarotoxin Life Sciences Ligands Molecular Biology Peptide synthesis Peptides Peptides - chemical synthesis Peptides - chemistry Residues Tobacco smoke Torpedo
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