Mammalian INO80 chromatin remodeler cooperates with FANCM to mediate DNA interstrand crosslink-induced checkpoint activation and repair

•Ino80-depleted cells are defective in interstrand crosslink repair.•Ino80 deficiency leads to impaired ATR-dependent DNA damage signaling in response to interstrand crosslinks.•Ino80 and FANCM interact at sites of damage and cooperate in interstrand crosslink-induced checkpoint activation. Chromati...

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Veröffentlicht in:	DNA repair 2019-02, Vol.74, p.38-50
Hauptverfasser:	Andreev, Veselin, Hristova, Rossitsa, Asparuhova, Mila, Danovski, Georgi, Stoynov, Stoyno, Gospodinov, Anastas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Checkpoints Checkpoint Chromatin Assembly and Disassembly Chromatin remodeling DNA - chemistry DNA - genetics DNA Damage DNA Helicases - deficiency DNA Helicases - genetics DNA Helicases - metabolism DNA Repair Gene Knockdown Techniques HeLa Cells Humans Ino80 Interstrand crosslinks Microfilament Proteins - deficiency PC-3 Cells Protein Binding Replication Protein A - genetics
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