Sevoflurane exposure has minimal effect on cognitive function and does not alter microglial activation in adult monkeys

•An 8-hour exposure to sevoflurane did not cause an increase in neuroinflammation as measured by [18F]-FEPPA in aged monkeys.•Extended exposure to sevoflurane had minimal impact on the performance of aged monkeys trained on cognitive test battery.•Extended exposure to sevoflurane in aged adult anima...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2019-03, Vol.71, p.159-167
Hauptverfasser:	Walters, Jennifer L., Zhang, Xuan, Talpos, John C., Fogle, Charles M., Li, Mi, Chelonis, John J., Paule, Merle G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adult monkey Anesthesia Anesthetics, Inhalation - toxicity Animals Biomarkers Brain Brain - drug effects Brain - metabolism Brain - pathology Cognition Cognitive ability Cognitive tasks Computed tomography Conditioning, Operant - drug effects Encephalitis - chemically induced Exposure Female Fluorine isotopes Geriatrics Learning - drug effects Macaca mulatta Male Microglia Microglia - drug effects Microglia - metabolism microPET imaging Monkeys Neural inflammation Neuroimaging Older people Operant conditioning Pathogenesis Positron emission Positron emission tomography Primates Rodents Sevoflurane Sevoflurane - toxicity Surgery Tomography
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