Non-redundant functions of EMT transcription factors
Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metasta...
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| Veröffentlicht in: | Nature cell biology 2019-01, Vol.21 (1), p.102-112 |
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| creator | Stemmler, Marc P. Eccles, Rebecca L. Brabletz, Simone Brabletz, Thomas |
| description | Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.
This Review describes non-redundant functions of the core transcription factors that mediate the epithelial–mesenchymal transition, and discusses the conflicting results regarding their roles in this process. |
| doi_str_mv | 10.1038/s41556-018-0196-y |
| format | Article |
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Academic</collection><jtitle>Nature cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stemmler, Marc P.</au><au>Eccles, Rebecca L.</au><au>Brabletz, Simone</au><au>Brabletz, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-redundant functions of EMT transcription factors</atitle><jtitle>Nature cell biology</jtitle><stitle>Nat Cell Biol</stitle><addtitle>Nat Cell Biol</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>21</volume><issue>1</issue><spage>102</spage><epage>112</epage><pages>102-112</pages><issn>1465-7392</issn><eissn>1476-4679</eissn><abstract>Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.
This Review describes non-redundant functions of the core transcription factors that mediate the epithelial–mesenchymal transition, and discusses the conflicting results regarding their roles in this process.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30602760</pmid><doi>10.1038/s41556-018-0196-y</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7866-3686</orcidid></addata></record> |
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| subjects | 13/106 13/51 13/95 631/80 692/699 96/95 Animals Biomedical and Life Sciences Cancer Cancer metastasis Cancer Research Cell Biology Developmental Biology DNA binding proteins Embryonic development Embryonic Development - genetics Embryos Epithelial-Mesenchymal Transition - genetics Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic aspects Homeostasis Humans Life Sciences Mesenchyme Metastases Models, Genetic Neoplasms - genetics Neoplasms - pathology Review Article Stem Cells Transcription factors Transcription Factors - genetics Universities and colleges |
| title | Non-redundant functions of EMT transcription factors |
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