Metabolically Healthy Obesity and Risk for Atrial Fibrillation: The HUNT Study
Objective Atrial fibrillation (AF) is the most common arrhythmia and has been described as a global epidemic. Although AF is associated with both obesity and its metabolic consequences, little is known about the association between metabolically healthy obesity and AF. Methods In a population‐based...
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| Veröffentlicht in: | OBESITY 2019-02, Vol.27 (2), p.332-338 |
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| creator | Feng, Tingting Vegard, Malmo Strand, Linn B. Laugsand, Lars E. Mørkedal, Bjørn Aune, Dagfinn Vatten, Lars Ellekjær, Hanne Loennechen, Jan P. Mukamal, Kenneth Janszky, Imre |
| description | Objective
Atrial fibrillation (AF) is the most common arrhythmia and has been described as a global epidemic. Although AF is associated with both obesity and its metabolic consequences, little is known about the association between metabolically healthy obesity and AF.
Methods
In a population‐based study, 47,870 adults were followed for incident AF from 2006 to 2008 until 2015. Participants were classified according to BMI and metabolic status (using waist circumference, triglycerides, high‐density lipoprotein cholesterol, blood pressure, and glucose) at baseline.
Results
During a median follow‐up of 8.1 years, 1,758 participants developed AF. Compared with metabolically healthy individuals with BMI |
| doi_str_mv | 10.1002/oby.22377 |
| format | Article |
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Atrial fibrillation (AF) is the most common arrhythmia and has been described as a global epidemic. Although AF is associated with both obesity and its metabolic consequences, little is known about the association between metabolically healthy obesity and AF.
Methods
In a population‐based study, 47,870 adults were followed for incident AF from 2006 to 2008 until 2015. Participants were classified according to BMI and metabolic status (using waist circumference, triglycerides, high‐density lipoprotein cholesterol, blood pressure, and glucose) at baseline.
Results
During a median follow‐up of 8.1 years, 1,758 participants developed AF. Compared with metabolically healthy individuals with BMI < 25 kg/m2, the multivariable‐adjusted hazard ratios for metabolically healthy and unhealthy obesity were 1.6 (95% CI: 1.2 to 2.1) and 1.6 (95% CI: 1.3 to 1.9), respectively. AF risk increased according to the severity of obesity.
Conclusions
Metabolically healthy and unhealthy obesity increased AF risk to a similar extent. Severity of obesity was positively associated with AF risk regardless of metabolic status.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.22377</identifier><identifier>PMID: 30605242</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Atrial Fibrillation - etiology ; Atrial Fibrillation - pathology ; Blood pressure ; Body mass index ; Cardiac arrhythmia ; Diabetes ; Epidemiology ; Female ; Glucose ; Health care ; Health risk assessment ; Heart ; Humans ; Male ; Metabolic syndrome ; Middle Aged ; Mortality ; Obesity ; Obesity, Metabolically Benign - complications ; Participation ; Population ; Risk Factors ; Studies ; Systematic review ; Triglycerides ; Weight control</subject><ispartof>OBESITY, 2019-02, Vol.27 (2), p.332-338</ispartof><rights>2019 The Obesity Society</rights><rights>2019 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Feb 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4267-b1fe2d69c9842fa020d2da757e7276f1b1529c7ec8bdecf4fba85d56c96b016a3</citedby><cites>FETCH-LOGICAL-c4267-b1fe2d69c9842fa020d2da757e7276f1b1529c7ec8bdecf4fba85d56c96b016a3</cites><orcidid>0000-0002-3987-5424</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.22377$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.22377$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30605242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:140088652$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Tingting</creatorcontrib><creatorcontrib>Vegard, Malmo</creatorcontrib><creatorcontrib>Strand, Linn B.</creatorcontrib><creatorcontrib>Laugsand, Lars E.</creatorcontrib><creatorcontrib>Mørkedal, Bjørn</creatorcontrib><creatorcontrib>Aune, Dagfinn</creatorcontrib><creatorcontrib>Vatten, Lars</creatorcontrib><creatorcontrib>Ellekjær, Hanne</creatorcontrib><creatorcontrib>Loennechen, Jan P.</creatorcontrib><creatorcontrib>Mukamal, Kenneth</creatorcontrib><creatorcontrib>Janszky, Imre</creatorcontrib><title>Metabolically Healthy Obesity and Risk for Atrial Fibrillation: The HUNT Study</title><title>OBESITY</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Atrial fibrillation (AF) is the most common arrhythmia and has been described as a global epidemic. Although AF is associated with both obesity and its metabolic consequences, little is known about the association between metabolically healthy obesity and AF.
Methods
In a population‐based study, 47,870 adults were followed for incident AF from 2006 to 2008 until 2015. Participants were classified according to BMI and metabolic status (using waist circumference, triglycerides, high‐density lipoprotein cholesterol, blood pressure, and glucose) at baseline.
Results
During a median follow‐up of 8.1 years, 1,758 participants developed AF. Compared with metabolically healthy individuals with BMI < 25 kg/m2, the multivariable‐adjusted hazard ratios for metabolically healthy and unhealthy obesity were 1.6 (95% CI: 1.2 to 2.1) and 1.6 (95% CI: 1.3 to 1.9), respectively. AF risk increased according to the severity of obesity.
Conclusions
Metabolically healthy and unhealthy obesity increased AF risk to a similar extent. Severity of obesity was positively associated with AF risk regardless of metabolic status.</description><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - pathology</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiac arrhythmia</subject><subject>Diabetes</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Glucose</subject><subject>Health care</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Obesity, Metabolically Benign - complications</subject><subject>Participation</subject><subject>Population</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Triglycerides</subject><subject>Weight control</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10UFr2zAYBmAxVtqu62F_YAh22Q5uJdmW7N2ysDaFroE2he0kJPkzUapEqWRT_O-n1mkOhYJAH-LhRdKL0BdKzigh7Nzr4YyxXIgP6JjWOclEXv_9uJ8reoQ-xbgipOCkpIfoKCdpYAU7Rjd_oFPaO2uUcwOegXLdcsBzDdF2A1abBt_a-IBbH_CkC1Y5fGF1sM6pzvrNT7xYAp7d3yzwXdc3w2d00CoX4XS3n6D7i9-L6Sy7nl9eTSfXmSkYF5mmLbCG16auCtYqwkjDGiVKAYIJ3lJNS1YbAabSDZi2aLWqyqbkpuaaUK7yE5SNufEJtr2W22DXKgzSKyt3Rw9pAllUOSnz5L-Pfhv8Yw-xk2sbDaRXbMD3UTLKc0JZ-sREv72hK9-HTXpNUoJzWqeV1I9RmeBjDNDur0CJfC5FplLkSynJft0l9noNzV6-tpDA-QierIPh_SQ5__VvjPwP0H6VSA</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Feng, Tingting</creator><creator>Vegard, Malmo</creator><creator>Strand, Linn B.</creator><creator>Laugsand, Lars E.</creator><creator>Mørkedal, Bjørn</creator><creator>Aune, Dagfinn</creator><creator>Vatten, Lars</creator><creator>Ellekjær, Hanne</creator><creator>Loennechen, Jan P.</creator><creator>Mukamal, Kenneth</creator><creator>Janszky, Imre</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0002-3987-5424</orcidid></search><sort><creationdate>201902</creationdate><title>Metabolically Healthy Obesity and Risk for Atrial Fibrillation: The HUNT Study</title><author>Feng, Tingting ; Vegard, Malmo ; Strand, Linn B. ; Laugsand, Lars E. ; Mørkedal, Bjørn ; Aune, Dagfinn ; Vatten, Lars ; Ellekjær, Hanne ; Loennechen, Jan P. ; Mukamal, Kenneth ; Janszky, Imre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4267-b1fe2d69c9842fa020d2da757e7276f1b1529c7ec8bdecf4fba85d56c96b016a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - pathology</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiac arrhythmia</topic><topic>Diabetes</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Glucose</topic><topic>Health care</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Obesity, Metabolically Benign - complications</topic><topic>Participation</topic><topic>Population</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Systematic review</topic><topic>Triglycerides</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Tingting</creatorcontrib><creatorcontrib>Vegard, Malmo</creatorcontrib><creatorcontrib>Strand, Linn B.</creatorcontrib><creatorcontrib>Laugsand, Lars E.</creatorcontrib><creatorcontrib>Mørkedal, Bjørn</creatorcontrib><creatorcontrib>Aune, Dagfinn</creatorcontrib><creatorcontrib>Vatten, Lars</creatorcontrib><creatorcontrib>Ellekjær, Hanne</creatorcontrib><creatorcontrib>Loennechen, Jan P.</creatorcontrib><creatorcontrib>Mukamal, Kenneth</creatorcontrib><creatorcontrib>Janszky, Imre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>OBESITY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Tingting</au><au>Vegard, Malmo</au><au>Strand, Linn B.</au><au>Laugsand, Lars E.</au><au>Mørkedal, Bjørn</au><au>Aune, Dagfinn</au><au>Vatten, Lars</au><au>Ellekjær, Hanne</au><au>Loennechen, Jan P.</au><au>Mukamal, Kenneth</au><au>Janszky, Imre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolically Healthy Obesity and Risk for Atrial Fibrillation: The HUNT Study</atitle><jtitle>OBESITY</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2019-02</date><risdate>2019</risdate><volume>27</volume><issue>2</issue><spage>332</spage><epage>338</epage><pages>332-338</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Atrial fibrillation (AF) is the most common arrhythmia and has been described as a global epidemic. Although AF is associated with both obesity and its metabolic consequences, little is known about the association between metabolically healthy obesity and AF.
Methods
In a population‐based study, 47,870 adults were followed for incident AF from 2006 to 2008 until 2015. Participants were classified according to BMI and metabolic status (using waist circumference, triglycerides, high‐density lipoprotein cholesterol, blood pressure, and glucose) at baseline.
Results
During a median follow‐up of 8.1 years, 1,758 participants developed AF. Compared with metabolically healthy individuals with BMI < 25 kg/m2, the multivariable‐adjusted hazard ratios for metabolically healthy and unhealthy obesity were 1.6 (95% CI: 1.2 to 2.1) and 1.6 (95% CI: 1.3 to 1.9), respectively. AF risk increased according to the severity of obesity.
Conclusions
Metabolically healthy and unhealthy obesity increased AF risk to a similar extent. Severity of obesity was positively associated with AF risk regardless of metabolic status.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>30605242</pmid><doi>10.1002/oby.22377</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3987-5424</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content |
| subjects | Atrial Fibrillation - etiology Atrial Fibrillation - pathology Blood pressure Body mass index Cardiac arrhythmia Diabetes Epidemiology Female Glucose Health care Health risk assessment Heart Humans Male Metabolic syndrome Middle Aged Mortality Obesity Obesity, Metabolically Benign - complications Participation Population Risk Factors Studies Systematic review Triglycerides Weight control |
| title | Metabolically Healthy Obesity and Risk for Atrial Fibrillation: The HUNT Study |
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