Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil

Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil

Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-β-cyclodextrin (SCD) and an anti-cancer prodrug, i.e. choline modifi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-01, Vol.55 (7), p.953-956
Hauptverfasser: Guan, Xinran, Chen, Yong, Wu, Xuan, Li, Peiyu, Liu, Yu
Format: Artikel
Sprache:eng
Schlagworte:
Assembly
Biocompatibility
Cancer
Choline
Controlled release
Cyclodextrins
Drug delivery systems
Enzymes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 956
container_issue 7
container_start_page 953
container_title Chemical communications (Cambridge, England)
container_volume 55
creator Guan, Xinran
Chen, Yong
Wu, Xuan
Li, Peiyu
Liu, Yu
description Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-β-cyclodextrin (SCD) and an anti-cancer prodrug, i.e. choline modified anti-cancer drug chlorambucil (QA-Cbl). The supramolecular assembly acts as an effective drug delivery system via the controlled drug loading and enzyme-responsive drug release, because the butyrylcholinesterase (BChE) can cleave the ester bond of QA-Cbl prodrug, resulting in the release of anti-cancer drug chlorambucil (Cbl). Compared to other sophisticated drug delivery systems, the present system provides a feasible and functional approach for achievement of controlled drug release.
doi_str_mv 10.1039/c8cc09047e
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2163011807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2163011807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-ea785899dc8c8c961ce651b6202c962c5649085efece2fb6b34e72c66e28efc93</originalsourceid><addsrcrecordid>eNpdkU1LxDAQhoMorl8Xf4AUvIhQN2maND1KWT9gwYuCt5JOp9olbdakFVfwv5t1Vw_OZWaYh5d5eQk5ZfSKUZ5PQQHQnKYZ7pADxmUai1Q9765nkccZT8WEHHq_oKGYUPtkwqkMuOIH5GvWf646jB36pe19-46RH02jBwsrMLbGj8G1_XTpbO3Gl3BbOt1ZgzAa7SLtPXaVWUWNdRHYfnDWGKwjhwa1x8g2ke6HNgbdA7roRwJejQ0a1QitOSZ7jTYeT7b9iDzdzB6Lu3j-cHtfXM9j4EwMMepMCZXndXCqIJcMUApWyYQmYUtAyDSnSmCDgElTyYqnmCUgJSYKG8j5EbnY6AYfbyP6oexaD2iM7tGOvkyY5JQxRbOAnv9DF3Z0ffhuTSnKslTIQF1uKHDWe4dNuXRtp92qZLRch1IWqih-QpkF-GwrOVYd1n_obwr8G9_7irk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2168017456</pqid></control><display><type>article</type><title>Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Guan, Xinran ; Chen, Yong ; Wu, Xuan ; Li, Peiyu ; Liu, Yu</creator><creatorcontrib>Guan, Xinran ; Chen, Yong ; Wu, Xuan ; Li, Peiyu ; Liu, Yu</creatorcontrib><description>Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-β-cyclodextrin (SCD) and an anti-cancer prodrug, i.e. choline modified anti-cancer drug chlorambucil (QA-Cbl). The supramolecular assembly acts as an effective drug delivery system via the controlled drug loading and enzyme-responsive drug release, because the butyrylcholinesterase (BChE) can cleave the ester bond of QA-Cbl prodrug, resulting in the release of anti-cancer drug chlorambucil (Cbl). Compared to other sophisticated drug delivery systems, the present system provides a feasible and functional approach for achievement of controlled drug release.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c8cc09047e</identifier><identifier>PMID: 30604783</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Assembly ; Biocompatibility ; Cancer ; Choline ; Controlled release ; Cyclodextrins ; Drug delivery systems ; Enzymes</subject><ispartof>Chemical communications (Cambridge, England), 2019-01, Vol.55 (7), p.953-956</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-ea785899dc8c8c961ce651b6202c962c5649085efece2fb6b34e72c66e28efc93</citedby><cites>FETCH-LOGICAL-c315t-ea785899dc8c8c961ce651b6202c962c5649085efece2fb6b34e72c66e28efc93</cites><orcidid>0000-0001-8723-1896</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30604783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guan, Xinran</creatorcontrib><creatorcontrib>Chen, Yong</creatorcontrib><creatorcontrib>Wu, Xuan</creatorcontrib><creatorcontrib>Li, Peiyu</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><title>Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-β-cyclodextrin (SCD) and an anti-cancer prodrug, i.e. choline modified anti-cancer drug chlorambucil (QA-Cbl). The supramolecular assembly acts as an effective drug delivery system via the controlled drug loading and enzyme-responsive drug release, because the butyrylcholinesterase (BChE) can cleave the ester bond of QA-Cbl prodrug, resulting in the release of anti-cancer drug chlorambucil (Cbl). Compared to other sophisticated drug delivery systems, the present system provides a feasible and functional approach for achievement of controlled drug release.</description><subject>Assembly</subject><subject>Biocompatibility</subject><subject>Cancer</subject><subject>Choline</subject><subject>Controlled release</subject><subject>Cyclodextrins</subject><subject>Drug delivery systems</subject><subject>Enzymes</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkU1LxDAQhoMorl8Xf4AUvIhQN2maND1KWT9gwYuCt5JOp9olbdakFVfwv5t1Vw_OZWaYh5d5eQk5ZfSKUZ5PQQHQnKYZ7pADxmUai1Q9765nkccZT8WEHHq_oKGYUPtkwqkMuOIH5GvWf646jB36pe19-46RH02jBwsrMLbGj8G1_XTpbO3Gl3BbOt1ZgzAa7SLtPXaVWUWNdRHYfnDWGKwjhwa1x8g2ke6HNgbdA7roRwJejQ0a1QitOSZ7jTYeT7b9iDzdzB6Lu3j-cHtfXM9j4EwMMepMCZXndXCqIJcMUApWyYQmYUtAyDSnSmCDgElTyYqnmCUgJSYKG8j5EbnY6AYfbyP6oexaD2iM7tGOvkyY5JQxRbOAnv9DF3Z0ffhuTSnKslTIQF1uKHDWe4dNuXRtp92qZLRch1IWqih-QpkF-GwrOVYd1n_obwr8G9_7irk</recordid><startdate>20190117</startdate><enddate>20190117</enddate><creator>Guan, Xinran</creator><creator>Chen, Yong</creator><creator>Wu, Xuan</creator><creator>Li, Peiyu</creator><creator>Liu, Yu</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8723-1896</orcidid></search><sort><creationdate>20190117</creationdate><title>Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil</title><author>Guan, Xinran ; Chen, Yong ; Wu, Xuan ; Li, Peiyu ; Liu, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-ea785899dc8c8c961ce651b6202c962c5649085efece2fb6b34e72c66e28efc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Assembly</topic><topic>Biocompatibility</topic><topic>Cancer</topic><topic>Choline</topic><topic>Controlled release</topic><topic>Cyclodextrins</topic><topic>Drug delivery systems</topic><topic>Enzymes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guan, Xinran</creatorcontrib><creatorcontrib>Chen, Yong</creatorcontrib><creatorcontrib>Wu, Xuan</creatorcontrib><creatorcontrib>Li, Peiyu</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guan, Xinran</au><au>Chen, Yong</au><au>Wu, Xuan</au><au>Li, Peiyu</au><au>Liu, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2019-01-17</date><risdate>2019</risdate><volume>55</volume><issue>7</issue><spage>953</spage><epage>956</epage><pages>953-956</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Supramolecular drug delivery systems are becoming an increasingly important part in controlled drug release. In this work, we report a novel enzyme-responsive supramolecular assembly directly constructed using biocompatible sulfato-β-cyclodextrin (SCD) and an anti-cancer prodrug, i.e. choline modified anti-cancer drug chlorambucil (QA-Cbl). The supramolecular assembly acts as an effective drug delivery system via the controlled drug loading and enzyme-responsive drug release, because the butyrylcholinesterase (BChE) can cleave the ester bond of QA-Cbl prodrug, resulting in the release of anti-cancer drug chlorambucil (Cbl). Compared to other sophisticated drug delivery systems, the present system provides a feasible and functional approach for achievement of controlled drug release.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30604783</pmid><doi>10.1039/c8cc09047e</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-8723-1896</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1359-7345
ispartof Chemical communications (Cambridge, England), 2019-01, Vol.55 (7), p.953-956
issn 1359-7345
1364-548X
language eng
recordid cdi_proquest_miscellaneous_2163011807
source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Assembly
Biocompatibility
Cancer
Choline
Controlled release
Cyclodextrins
Drug delivery systems
Enzymes
title Enzyme-responsive sulfatocyclodextrin/prodrug supramolecular assembly for controlled release of anti-cancer drug chlorambucil
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T16%3A39%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enzyme-responsive%20sulfatocyclodextrin/prodrug%20supramolecular%20assembly%20for%20controlled%20release%20of%20anti-cancer%20drug%20chlorambucil&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Guan,%20Xinran&rft.date=2019-01-17&rft.volume=55&rft.issue=7&rft.spage=953&rft.epage=956&rft.pages=953-956&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c8cc09047e&rft_dat=%3Cproquest_cross%3E2163011807%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2168017456&rft_id=info:pmid/30604783&rfr_iscdi=true