Sinomenine Attenuates Traumatic Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation via Nrf2 Pathway

Traumatic spinal cord injury (SCI) is a devastating condition with few efficacious drugs. Sinomenine, a bioactive alkaloid extracted from medicinal herb, has been used as a treatment of rheumatoid diseases. This present study explored the therapeutic effects of sinomenine on locomotor dysfunction an...

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Veröffentlicht in:	Neurochemical research 2019-04, Vol.44 (4), p.763-775
Hauptverfasser:	Zhang, Lilian, Zhang, Weijiang, Zheng, Binbin, Tian, Naifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Chemical compounds Cytokines Cytoplasm Detoxification Female Gene expression Herbal medicine Hydrogen peroxide Hydrogen Peroxide - toxicity Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Lipopolysaccharides Medical treatment Medicinal plants Morphinans - pharmacology Morphinans - therapeutic use Neurochemistry Neurological diseases Neurology Neurosciences NF-E2-Related Factor 2 - agonists NF-E2-Related Factor 2 - metabolism Nuclear transport Original Paper Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology PC12 Cells Pharmacology Pheochromocytoma cells Preservation Rats Rats, Sprague-Dawley Signal Transduction - drug effects Signal Transduction - physiology siRNA Spinal cord injuries Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Thoracic Vertebrae Translocation
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