Guest Solvent‐dependence of the Nanomechanical Response in Substituted Dihydropyrimidinone Crystals
The nanomechanical responses of two crystalline phases of a dihydropyrimidine analogue (1) were similar irrespective of the presence (or absence) of the guest solvent. In contrast, the mechanical responses of two differently solvated forms of the second related (2) crystals were significantly differ...
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| Veröffentlicht in: | Chemistry, an Asian journal an Asian journal, 2019-03, Vol.14 (5), p.607-611 |
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| container_end_page | 611 |
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| container_issue | 5 |
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| container_title | Chemistry, an Asian journal |
| container_volume | 14 |
| creator | Bhandary, Subhrajyoti Rani, Gulshan Mangalampalli, S. R. N. Kiran Rao, G. B. Dharma Ramamurty, Upadrasta Chopra, Deepak |
| description | The nanomechanical responses of two crystalline phases of a dihydropyrimidine analogue (1) were similar irrespective of the presence (or absence) of the guest solvent. In contrast, the mechanical responses of two differently solvated forms of the second related (2) crystals were significantly different. These contrasting behaviors are rationalized in terms of intermolecular interactions and energy distributions.
Guests come and go: Nanomechanical properties (hardness and elastic modulus) of molecular crystals alter depending upon the absence and presence of different guest solvent molecules for two dihydropyrimidine equivalents. A molecular basis in terms of intermolecular interaction patterns and energy distributions justifies the modulation of nanomechanical responses. |
| doi_str_mv | 10.1002/asia.201801842 |
| format | Article |
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Guests come and go: Nanomechanical properties (hardness and elastic modulus) of molecular crystals alter depending upon the absence and presence of different guest solvent molecules for two dihydropyrimidine equivalents. A molecular basis in terms of intermolecular interaction patterns and energy distributions justifies the modulation of nanomechanical responses.</description><identifier>ISSN: 1861-4728</identifier><identifier>EISSN: 1861-471X</identifier><identifier>DOI: 10.1002/asia.201801842</identifier><identifier>PMID: 30600930</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Chemistry ; Dependence ; dihydropyrimidine analogues ; interaction anisotropy ; nanoindentation ; nanomechanical response ; solvatomorphs ; Solvents</subject><ispartof>Chemistry, an Asian journal, 2019-03, Vol.14 (5), p.607-611</ispartof><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4392-c333092cba7c47b85a8447912eb901fc771dacc35aba08c4f191dd8ae29b77063</citedby><cites>FETCH-LOGICAL-c4392-c333092cba7c47b85a8447912eb901fc771dacc35aba08c4f191dd8ae29b77063</cites><orcidid>0000-0002-0018-6007 ; 0000-0002-0385-0604</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fasia.201801842$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fasia.201801842$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30600930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhandary, Subhrajyoti</creatorcontrib><creatorcontrib>Rani, Gulshan</creatorcontrib><creatorcontrib>Mangalampalli, S. R. N. Kiran</creatorcontrib><creatorcontrib>Rao, G. B. Dharma</creatorcontrib><creatorcontrib>Ramamurty, Upadrasta</creatorcontrib><creatorcontrib>Chopra, Deepak</creatorcontrib><title>Guest Solvent‐dependence of the Nanomechanical Response in Substituted Dihydropyrimidinone Crystals</title><title>Chemistry, an Asian journal</title><addtitle>Chem Asian J</addtitle><description>The nanomechanical responses of two crystalline phases of a dihydropyrimidine analogue (1) were similar irrespective of the presence (or absence) of the guest solvent. In contrast, the mechanical responses of two differently solvated forms of the second related (2) crystals were significantly different. These contrasting behaviors are rationalized in terms of intermolecular interactions and energy distributions.
Guests come and go: Nanomechanical properties (hardness and elastic modulus) of molecular crystals alter depending upon the absence and presence of different guest solvent molecules for two dihydropyrimidine equivalents. A molecular basis in terms of intermolecular interaction patterns and energy distributions justifies the modulation of nanomechanical responses.</description><subject>Chemistry</subject><subject>Dependence</subject><subject>dihydropyrimidine analogues</subject><subject>interaction anisotropy</subject><subject>nanoindentation</subject><subject>nanomechanical response</subject><subject>solvatomorphs</subject><subject>Solvents</subject><issn>1861-4728</issn><issn>1861-471X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkU1r3DAQhkVpyFdz7bEIesllNyPJa0nHZfPRQEgg20BuRpbGrIJXci07wbf8hP7G_pJ42XQDvRQGZg7PvMw7LyFfGUwZAD8zyZspB6bGyvgncshUziaZZI-fdzNXB-QopSeAGQet9smBgBxACzgkeNVj6ugy1s8Yuj-vvx02GBwGizRWtFshvTUhrtGuTPDW1PQeUxNDQuoDXfZl6nzXd-jouV8Nro3N0Pq1dz7EgHTRDqkzdfpC9qqx4cl7PyYPlxc_Fz8mN3dX14v5zcRmQvOJFUKA5rY00mayVDOjskxqxrHUwCorJXPGWjEzpQFls4pp5pwyyHUpJeTimJxudZs2_toYK9Y-WaxrEzD2qeAs51JKwTbo93_Qp9i3YbxupFSuJeegRmq6pWwbU2qxKprRnmmHgkGxCaDYBFDsAhgXvr3L9uUa3Q7_-_ER0Fvgxdc4_EeumC-v5x_ib9HPlDA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Bhandary, Subhrajyoti</creator><creator>Rani, Gulshan</creator><creator>Mangalampalli, S. R. N. Kiran</creator><creator>Rao, G. B. Dharma</creator><creator>Ramamurty, Upadrasta</creator><creator>Chopra, Deepak</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0018-6007</orcidid><orcidid>https://orcid.org/0000-0002-0385-0604</orcidid></search><sort><creationdate>20190301</creationdate><title>Guest Solvent‐dependence of the Nanomechanical Response in Substituted Dihydropyrimidinone Crystals</title><author>Bhandary, Subhrajyoti ; Rani, Gulshan ; Mangalampalli, S. R. N. Kiran ; Rao, G. B. Dharma ; Ramamurty, Upadrasta ; Chopra, Deepak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4392-c333092cba7c47b85a8447912eb901fc771dacc35aba08c4f191dd8ae29b77063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chemistry</topic><topic>Dependence</topic><topic>dihydropyrimidine analogues</topic><topic>interaction anisotropy</topic><topic>nanoindentation</topic><topic>nanomechanical response</topic><topic>solvatomorphs</topic><topic>Solvents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhandary, Subhrajyoti</creatorcontrib><creatorcontrib>Rani, Gulshan</creatorcontrib><creatorcontrib>Mangalampalli, S. R. N. Kiran</creatorcontrib><creatorcontrib>Rao, G. B. Dharma</creatorcontrib><creatorcontrib>Ramamurty, Upadrasta</creatorcontrib><creatorcontrib>Chopra, Deepak</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry, an Asian journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhandary, Subhrajyoti</au><au>Rani, Gulshan</au><au>Mangalampalli, S. R. N. Kiran</au><au>Rao, G. B. Dharma</au><au>Ramamurty, Upadrasta</au><au>Chopra, Deepak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Guest Solvent‐dependence of the Nanomechanical Response in Substituted Dihydropyrimidinone Crystals</atitle><jtitle>Chemistry, an Asian journal</jtitle><addtitle>Chem Asian J</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>14</volume><issue>5</issue><spage>607</spage><epage>611</epage><pages>607-611</pages><issn>1861-4728</issn><eissn>1861-471X</eissn><abstract>The nanomechanical responses of two crystalline phases of a dihydropyrimidine analogue (1) were similar irrespective of the presence (or absence) of the guest solvent. In contrast, the mechanical responses of two differently solvated forms of the second related (2) crystals were significantly different. These contrasting behaviors are rationalized in terms of intermolecular interactions and energy distributions.
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| subjects | Chemistry Dependence dihydropyrimidine analogues interaction anisotropy nanoindentation nanomechanical response solvatomorphs Solvents |
| title | Guest Solvent‐dependence of the Nanomechanical Response in Substituted Dihydropyrimidinone Crystals |
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