Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches
The present cross-sectional, hospital-based study was carried out on 146 Egyptian male children, 73 males with autism who were comparable with another 73 healthy age- and sex-matched children, recruited from the outpatients’ psychiatric clinics of the Neuropsychiatric and Pediatric Departments of So...
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| Veröffentlicht in: | Journal of molecular neuroscience 2019-02, Vol.67 (2), p.204-216 |
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| creator | Hassan, Mohammed H. Desoky, Tarek Sakhr, Hala M. Gabra, Romany H. Bakri, Ali Helmi |
| description | The present cross-sectional, hospital-based study was carried out on 146 Egyptian male children, 73 males with autism who were comparable with another 73 healthy age- and sex-matched children, recruited from the outpatients’ psychiatric clinics of the Neuropsychiatric and Pediatric Departments of South Valley and Assiut University Hospitals, Egypt. Neuropsychological assessments of autistic males were done using CARS, short sensory profile and intelligent quotients. Serum markers of mitochondrial dysfunction (lactate, pyruvate, and lactate to pyruvate ratio, creatine kinase (CK),
l
-carnitine, ammonia, lactate dehydrogenase, pyruvate kinase, alanine transaminase and aspartate transaminase), oxidative stress and blood levels of heavy metals (mercury, lead and aluminium) were measured. Serum cholesterol, cortisol, free testosterone, estradiol, dehydroepiandrostenedione, adenosine deaminase and
Helicobacter pylori
antigen in stool were also performed. There was evidence of mitochondrial dysfunction among autistic children. Additionally, there were significantly lower serum total cholesterol, cortisol and estradiol as well as significantly higher dehydroepiandrostenedione (DHEA) and free testosterone (
p
|
| doi_str_mv | 10.1007/s12031-018-1225-9 |
| format | Article |
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l
-carnitine, ammonia, lactate dehydrogenase, pyruvate kinase, alanine transaminase and aspartate transaminase), oxidative stress and blood levels of heavy metals (mercury, lead and aluminium) were measured. Serum cholesterol, cortisol, free testosterone, estradiol, dehydroepiandrostenedione, adenosine deaminase and
Helicobacter pylori
antigen in stool were also performed. There was evidence of mitochondrial dysfunction among autistic children. Additionally, there were significantly lower serum total cholesterol, cortisol and estradiol as well as significantly higher dehydroepiandrostenedione (DHEA) and free testosterone (
p
< 0.05 for all markers). Twenty-eight (38%) cases were positive for
H. pylori
antigen in their stool with significant higher serum ammonia and lower adenosine deaminase than in
H. pylori
-negative autistic children. Mitochondrial dysfunction,
H. pylori
infection and low cholesterol were prevalent among autistic male children, which should be targeted during autism management.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-018-1225-9</identifier><identifier>PMID: 30600432</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>17β-Estradiol ; Adenosine ; Adenosine deaminase ; Adenosine Deaminase - blood ; Alanine ; Alanine transaminase ; Aluminum ; Ammonia ; Antigens ; Antigens, Bacterial - analysis ; Aspartate transaminase ; Autism ; Autistic Disorder - blood ; Autistic Disorder - physiopathology ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Blood levels ; Carnitine ; Cell Biology ; Child ; Child, Preschool ; Children ; Cholesterol ; Cholesterol - blood ; Cortisol ; Creatine ; Creatine kinase ; Dehydroepiandrosterone ; Gonadal Steroid Hormones - blood ; Heavy metals ; Helicobacter pylori ; Helicobacter pylori - immunology ; Humans ; Hydrocortisone - blood ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Lead ; Male ; Males ; Markers ; Mercury ; Mercury (metal) ; Metabolome ; Metals, Heavy - blood ; Mitochondria ; Mitochondria - metabolism ; Neurochemistry ; Neurology ; Neurosciences ; Oxidative Stress ; Proteomics ; Pyruvate kinase ; Quotients ; Sex hormones ; Testosterone ; Weight reduction</subject><ispartof>Journal of molecular neuroscience, 2019-02, Vol.67 (2), p.204-216</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Journal of Molecular Neuroscience is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-c06413a56a1578fa10fbf4060c67080f34c85c1564733412a0389c3d336dd5073</citedby><cites>FETCH-LOGICAL-c372t-c06413a56a1578fa10fbf4060c67080f34c85c1564733412a0389c3d336dd5073</cites><orcidid>0000-0003-2698-9438</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-018-1225-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-018-1225-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30600432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassan, Mohammed H.</creatorcontrib><creatorcontrib>Desoky, Tarek</creatorcontrib><creatorcontrib>Sakhr, Hala M.</creatorcontrib><creatorcontrib>Gabra, Romany H.</creatorcontrib><creatorcontrib>Bakri, Ali Helmi</creatorcontrib><title>Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>The present cross-sectional, hospital-based study was carried out on 146 Egyptian male children, 73 males with autism who were comparable with another 73 healthy age- and sex-matched children, recruited from the outpatients’ psychiatric clinics of the Neuropsychiatric and Pediatric Departments of South Valley and Assiut University Hospitals, Egypt. Neuropsychological assessments of autistic males were done using CARS, short sensory profile and intelligent quotients. Serum markers of mitochondrial dysfunction (lactate, pyruvate, and lactate to pyruvate ratio, creatine kinase (CK),
l
-carnitine, ammonia, lactate dehydrogenase, pyruvate kinase, alanine transaminase and aspartate transaminase), oxidative stress and blood levels of heavy metals (mercury, lead and aluminium) were measured. Serum cholesterol, cortisol, free testosterone, estradiol, dehydroepiandrostenedione, adenosine deaminase and
Helicobacter pylori
antigen in stool were also performed. There was evidence of mitochondrial dysfunction among autistic children. Additionally, there were significantly lower serum total cholesterol, cortisol and estradiol as well as significantly higher dehydroepiandrostenedione (DHEA) and free testosterone (
p
< 0.05 for all markers). Twenty-eight (38%) cases were positive for
H. pylori
antigen in their stool with significant higher serum ammonia and lower adenosine deaminase than in
H. pylori
-negative autistic children. Mitochondrial dysfunction,
H. pylori
infection and low cholesterol were prevalent among autistic male children, which should be targeted during autism management.</description><subject>17β-Estradiol</subject><subject>Adenosine</subject><subject>Adenosine deaminase</subject><subject>Adenosine Deaminase - blood</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Aluminum</subject><subject>Ammonia</subject><subject>Antigens</subject><subject>Antigens, Bacterial - analysis</subject><subject>Aspartate transaminase</subject><subject>Autism</subject><subject>Autistic Disorder - blood</subject><subject>Autistic Disorder - physiopathology</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood levels</subject><subject>Carnitine</subject><subject>Cell Biology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cortisol</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Dehydroepiandrosterone</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Heavy metals</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - immunology</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Lead</subject><subject>Male</subject><subject>Males</subject><subject>Markers</subject><subject>Mercury</subject><subject>Mercury (metal)</subject><subject>Metabolome</subject><subject>Metals, Heavy - blood</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Oxidative Stress</subject><subject>Proteomics</subject><subject>Pyruvate kinase</subject><subject>Quotients</subject><subject>Sex hormones</subject><subject>Testosterone</subject><subject>Weight reduction</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1P3DAQhq2qqLss_IBeqki9cEmZseOP9LasWorECg5wNl7HAa-cZLGTA_8ew9JWQuI0Gs0z74weQr4i_EAAeZqQAsMSUJVIKS_rT2SOnNclohCfyRxUzUslajEjhyltAShWqL6QGQMBUDE6J3fXQ0p-E1yxdqPZDMHbYhlGF83ohz4Vphv6-2I5jT6NebQ2mVw9-NBE1_8sVsH33ppQmL4pzvxgH1z32i93uziY3KYjctCakNzxW12Q29-_blZ_ysur84vV8rK0TNKxtCAqZIYLg1yq1iC0m7bKb1ohQUHLKqu4RS4qyViF1ABTtWUNY6JpOEi2ICf73Hz4cXJp1J1P1oVgejdMSVMUVEpJVZXR7-_Q7TDFPn_3SlFBGRWZwj1lY1YUXat30XcmPmkE_aJf7_XrrF-_6Nd13vn2ljxtOtf82_jrOwN0D6Q86u9d_H_649RnC-KNjQ</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Hassan, Mohammed H.</creator><creator>Desoky, Tarek</creator><creator>Sakhr, Hala M.</creator><creator>Gabra, Romany H.</creator><creator>Bakri, Ali Helmi</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2698-9438</orcidid></search><sort><creationdate>20190201</creationdate><title>Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches</title><author>Hassan, Mohammed H. ; Desoky, Tarek ; Sakhr, Hala M. ; Gabra, Romany H. ; Bakri, Ali Helmi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-c06413a56a1578fa10fbf4060c67080f34c85c1564733412a0389c3d336dd5073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>17β-Estradiol</topic><topic>Adenosine</topic><topic>Adenosine deaminase</topic><topic>Adenosine Deaminase - blood</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Aluminum</topic><topic>Ammonia</topic><topic>Antigens</topic><topic>Antigens, Bacterial - analysis</topic><topic>Aspartate transaminase</topic><topic>Autism</topic><topic>Autistic Disorder - blood</topic><topic>Autistic Disorder - physiopathology</topic><topic>Biomarkers - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood levels</topic><topic>Carnitine</topic><topic>Cell Biology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cortisol</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Dehydroepiandrosterone</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Heavy metals</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - immunology</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactate dehydrogenase</topic><topic>Lactic acid</topic><topic>Lead</topic><topic>Male</topic><topic>Males</topic><topic>Markers</topic><topic>Mercury</topic><topic>Mercury (metal)</topic><topic>Metabolome</topic><topic>Metals, Heavy - 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Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassan, Mohammed H.</au><au>Desoky, Tarek</au><au>Sakhr, Hala M.</au><au>Gabra, Romany H.</au><au>Bakri, Ali Helmi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches</atitle><jtitle>Journal of molecular neuroscience</jtitle><stitle>J Mol Neurosci</stitle><addtitle>J Mol Neurosci</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>67</volume><issue>2</issue><spage>204</spage><epage>216</epage><pages>204-216</pages><issn>0895-8696</issn><eissn>1559-1166</eissn><abstract>The present cross-sectional, hospital-based study was carried out on 146 Egyptian male children, 73 males with autism who were comparable with another 73 healthy age- and sex-matched children, recruited from the outpatients’ psychiatric clinics of the Neuropsychiatric and Pediatric Departments of South Valley and Assiut University Hospitals, Egypt. Neuropsychological assessments of autistic males were done using CARS, short sensory profile and intelligent quotients. Serum markers of mitochondrial dysfunction (lactate, pyruvate, and lactate to pyruvate ratio, creatine kinase (CK),
l
-carnitine, ammonia, lactate dehydrogenase, pyruvate kinase, alanine transaminase and aspartate transaminase), oxidative stress and blood levels of heavy metals (mercury, lead and aluminium) were measured. Serum cholesterol, cortisol, free testosterone, estradiol, dehydroepiandrostenedione, adenosine deaminase and
Helicobacter pylori
antigen in stool were also performed. There was evidence of mitochondrial dysfunction among autistic children. Additionally, there were significantly lower serum total cholesterol, cortisol and estradiol as well as significantly higher dehydroepiandrostenedione (DHEA) and free testosterone (
p
< 0.05 for all markers). Twenty-eight (38%) cases were positive for
H. pylori
antigen in their stool with significant higher serum ammonia and lower adenosine deaminase than in
H. pylori
-negative autistic children. Mitochondrial dysfunction,
H. pylori
infection and low cholesterol were prevalent among autistic male children, which should be targeted during autism management.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30600432</pmid><doi>10.1007/s12031-018-1225-9</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2698-9438</orcidid></addata></record> |
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| ispartof | Journal of molecular neuroscience, 2019-02, Vol.67 (2), p.204-216 |
| issn | 0895-8696 1559-1166 |
| language | eng |
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| subjects | 17β-Estradiol Adenosine Adenosine deaminase Adenosine Deaminase - blood Alanine Alanine transaminase Aluminum Ammonia Antigens Antigens, Bacterial - analysis Aspartate transaminase Autism Autistic Disorder - blood Autistic Disorder - physiopathology Biomarkers - blood Biomedical and Life Sciences Biomedicine Blood levels Carnitine Cell Biology Child Child, Preschool Children Cholesterol Cholesterol - blood Cortisol Creatine Creatine kinase Dehydroepiandrosterone Gonadal Steroid Hormones - blood Heavy metals Helicobacter pylori Helicobacter pylori - immunology Humans Hydrocortisone - blood L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lead Male Males Markers Mercury Mercury (metal) Metabolome Metals, Heavy - blood Mitochondria Mitochondria - metabolism Neurochemistry Neurology Neurosciences Oxidative Stress Proteomics Pyruvate kinase Quotients Sex hormones Testosterone Weight reduction |
| title | Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches |
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