Ultrasound assisted dispersive liquid-liquid microextraction for fast and accurate analysis of chloramphenicol in honey
Honey is a food produced from honey bee widely used for the sweetening power and for its biological properties. In order to prevent the infection of the hive, different xenobiotics (antibiotics, pesticide) were frequently employed. One of these substances is the chloramphenicol, that given its chemi...
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| Veröffentlicht in: | Food research international 2019-01, Vol.115, p.572-579 |
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| creator | Campone, Luca Celano, Rita Piccinelli, Anna Lisa Pagano, Imma Cicero, Nicola Sanzo, Rosa Di Carabetta, Sonia Russo, Mariateresa Rastrelli, Luca |
| description | Honey is a food produced from honey bee widely used for the sweetening power and for its biological properties. In order to prevent the infection of the hive, different xenobiotics (antibiotics, pesticide) were frequently employed. One of these substances is the chloramphenicol, that given its chemical stability could often found in food. Chloramphenicol have several side effects in humans after their ingestion and for this reason their intake must be avoid. The aim of this study, was developed an ultrasound-assisted dispersive liquid-liquid microextraction method coupled with UHPLC MS/MS determination, for fast and accurate analysis of chloramphenicol in honey. The parameters affecting on extraction efficiency were carefully optimized using an experimental design in order to maximized the recovery reducing matrix effects. After the optimization the method was validated and successfully applied to 66 honey samples.
[Display omitted]
•Fast and easy analysis of chloramphenicol•Validation method for the analysis of chloramphenicol in honey•Optimization of extraction parameters by response surface design•Innovative extraction technique for determination of chloramphenicol in honey. |
| doi_str_mv | 10.1016/j.foodres.2018.09.006 |
| format | Article |
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[Display omitted]
•Fast and easy analysis of chloramphenicol•Validation method for the analysis of chloramphenicol in honey•Optimization of extraction parameters by response surface design•Innovative extraction technique for determination of chloramphenicol in honey.</description><identifier>ISSN: 0963-9969</identifier><identifier>EISSN: 1873-7145</identifier><identifier>DOI: 10.1016/j.foodres.2018.09.006</identifier><identifier>PMID: 30599981</identifier><language>eng</language><publisher>Canada: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - analysis ; Chloramphenicol - adverse effects ; Chloramphenicol - analysis ; Chloramphenicol quantitative analysis ; Chromatography, High Pressure Liquid - methods ; Experimental design optimisation ; Honey ; Honey - analysis ; Humans ; Limit of Detection ; Liquid Phase Microextraction - methods ; Pesticides - analysis ; Tandem Mass Spectrometry - methods ; UA-DLLME ; UHPLC MS/MS ; Ultrasonic Waves ; Validation Reg. 2002/657 EC ; Xenobiotics - analysis</subject><ispartof>Food research international, 2019-01, Vol.115, p.572-579</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-262bc2b1418a8ee2387463242a8ed3def88f1c27a83da60f4cc0125defea62403</citedby><cites>FETCH-LOGICAL-c365t-262bc2b1418a8ee2387463242a8ed3def88f1c27a83da60f4cc0125defea62403</cites><orcidid>0000-0002-8055-1915 ; 0000-0002-4729-2384 ; 0000-0001-7993-687X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodres.2018.09.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30599981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campone, Luca</creatorcontrib><creatorcontrib>Celano, Rita</creatorcontrib><creatorcontrib>Piccinelli, Anna Lisa</creatorcontrib><creatorcontrib>Pagano, Imma</creatorcontrib><creatorcontrib>Cicero, Nicola</creatorcontrib><creatorcontrib>Sanzo, Rosa Di</creatorcontrib><creatorcontrib>Carabetta, Sonia</creatorcontrib><creatorcontrib>Russo, Mariateresa</creatorcontrib><creatorcontrib>Rastrelli, Luca</creatorcontrib><title>Ultrasound assisted dispersive liquid-liquid microextraction for fast and accurate analysis of chloramphenicol in honey</title><title>Food research international</title><addtitle>Food Res Int</addtitle><description>Honey is a food produced from honey bee widely used for the sweetening power and for its biological properties. In order to prevent the infection of the hive, different xenobiotics (antibiotics, pesticide) were frequently employed. One of these substances is the chloramphenicol, that given its chemical stability could often found in food. Chloramphenicol have several side effects in humans after their ingestion and for this reason their intake must be avoid. The aim of this study, was developed an ultrasound-assisted dispersive liquid-liquid microextraction method coupled with UHPLC MS/MS determination, for fast and accurate analysis of chloramphenicol in honey. The parameters affecting on extraction efficiency were carefully optimized using an experimental design in order to maximized the recovery reducing matrix effects. After the optimization the method was validated and successfully applied to 66 honey samples.
[Display omitted]
•Fast and easy analysis of chloramphenicol•Validation method for the analysis of chloramphenicol in honey•Optimization of extraction parameters by response surface design•Innovative extraction technique for determination of chloramphenicol in honey.</description><subject>Anti-Bacterial Agents - analysis</subject><subject>Chloramphenicol - adverse effects</subject><subject>Chloramphenicol - analysis</subject><subject>Chloramphenicol quantitative analysis</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Experimental design optimisation</subject><subject>Honey</subject><subject>Honey - analysis</subject><subject>Humans</subject><subject>Limit of Detection</subject><subject>Liquid Phase Microextraction - methods</subject><subject>Pesticides - analysis</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>UA-DLLME</subject><subject>UHPLC MS/MS</subject><subject>Ultrasonic Waves</subject><subject>Validation Reg. 2002/657 EC</subject><subject>Xenobiotics - analysis</subject><issn>0963-9969</issn><issn>1873-7145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERZfCTwD5yCXBH4ljnxCqoCBV4kLPltcea71K4q0nKey_r1e79MppNJrnndE8hHzgrOWMq8_7NuYcCmArGNctMy1j6hXZcD3IZuBd_5psmFGyMUaZa_IWcc8q0Q_mDbmWrDfGaL4hfx7GpTjM6xyoQ0y4QKAh4QEKpiegY3pcU2jOhU7Jlwx_a8IvKc805kKjw4W6U9z7tbgFauPGY11Fc6R-N-bipsMO5uTzSNNMd3mG4ztyFd2I8P5Sb8jD92-_b38097_uft5-vW-8VP3SCCW2Xmx5x7XTAELqoVNSdKJ2QQaIWkfuxeC0DE6x2HnPuOjrAJwSHZM35NN576HkxxVwsVNCD-PoZsgrWsGVGIZOSlPR_ozWHxELRHsoaXLlaDmzJ-d2by_O7cm5ZcZWozX38XJi3U4QXlL_JFfgyxmA-uhTgmLRJ5g9hFTALzbk9J8Tzy0jmQg</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Campone, Luca</creator><creator>Celano, Rita</creator><creator>Piccinelli, Anna Lisa</creator><creator>Pagano, Imma</creator><creator>Cicero, Nicola</creator><creator>Sanzo, Rosa Di</creator><creator>Carabetta, Sonia</creator><creator>Russo, Mariateresa</creator><creator>Rastrelli, Luca</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8055-1915</orcidid><orcidid>https://orcid.org/0000-0002-4729-2384</orcidid><orcidid>https://orcid.org/0000-0001-7993-687X</orcidid></search><sort><creationdate>201901</creationdate><title>Ultrasound assisted dispersive liquid-liquid microextraction for fast and accurate analysis of chloramphenicol in honey</title><author>Campone, Luca ; Celano, Rita ; Piccinelli, Anna Lisa ; Pagano, Imma ; Cicero, Nicola ; Sanzo, Rosa Di ; Carabetta, Sonia ; Russo, Mariateresa ; Rastrelli, Luca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-262bc2b1418a8ee2387463242a8ed3def88f1c27a83da60f4cc0125defea62403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anti-Bacterial Agents - analysis</topic><topic>Chloramphenicol - adverse effects</topic><topic>Chloramphenicol - analysis</topic><topic>Chloramphenicol quantitative analysis</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Experimental design optimisation</topic><topic>Honey</topic><topic>Honey - analysis</topic><topic>Humans</topic><topic>Limit of Detection</topic><topic>Liquid Phase Microextraction - methods</topic><topic>Pesticides - analysis</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>UA-DLLME</topic><topic>UHPLC MS/MS</topic><topic>Ultrasonic Waves</topic><topic>Validation Reg. 2002/657 EC</topic><topic>Xenobiotics - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campone, Luca</creatorcontrib><creatorcontrib>Celano, Rita</creatorcontrib><creatorcontrib>Piccinelli, Anna Lisa</creatorcontrib><creatorcontrib>Pagano, Imma</creatorcontrib><creatorcontrib>Cicero, Nicola</creatorcontrib><creatorcontrib>Sanzo, Rosa Di</creatorcontrib><creatorcontrib>Carabetta, Sonia</creatorcontrib><creatorcontrib>Russo, Mariateresa</creatorcontrib><creatorcontrib>Rastrelli, Luca</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campone, Luca</au><au>Celano, Rita</au><au>Piccinelli, Anna Lisa</au><au>Pagano, Imma</au><au>Cicero, Nicola</au><au>Sanzo, Rosa Di</au><au>Carabetta, Sonia</au><au>Russo, Mariateresa</au><au>Rastrelli, Luca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasound assisted dispersive liquid-liquid microextraction for fast and accurate analysis of chloramphenicol in honey</atitle><jtitle>Food research international</jtitle><addtitle>Food Res Int</addtitle><date>2019-01</date><risdate>2019</risdate><volume>115</volume><spage>572</spage><epage>579</epage><pages>572-579</pages><issn>0963-9969</issn><eissn>1873-7145</eissn><abstract>Honey is a food produced from honey bee widely used for the sweetening power and for its biological properties. In order to prevent the infection of the hive, different xenobiotics (antibiotics, pesticide) were frequently employed. One of these substances is the chloramphenicol, that given its chemical stability could often found in food. Chloramphenicol have several side effects in humans after their ingestion and for this reason their intake must be avoid. The aim of this study, was developed an ultrasound-assisted dispersive liquid-liquid microextraction method coupled with UHPLC MS/MS determination, for fast and accurate analysis of chloramphenicol in honey. The parameters affecting on extraction efficiency were carefully optimized using an experimental design in order to maximized the recovery reducing matrix effects. After the optimization the method was validated and successfully applied to 66 honey samples.
[Display omitted]
•Fast and easy analysis of chloramphenicol•Validation method for the analysis of chloramphenicol in honey•Optimization of extraction parameters by response surface design•Innovative extraction technique for determination of chloramphenicol in honey.</abstract><cop>Canada</cop><pub>Elsevier Ltd</pub><pmid>30599981</pmid><doi>10.1016/j.foodres.2018.09.006</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8055-1915</orcidid><orcidid>https://orcid.org/0000-0002-4729-2384</orcidid><orcidid>https://orcid.org/0000-0001-7993-687X</orcidid></addata></record> |
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| subjects | Anti-Bacterial Agents - analysis Chloramphenicol - adverse effects Chloramphenicol - analysis Chloramphenicol quantitative analysis Chromatography, High Pressure Liquid - methods Experimental design optimisation Honey Honey - analysis Humans Limit of Detection Liquid Phase Microextraction - methods Pesticides - analysis Tandem Mass Spectrometry - methods UA-DLLME UHPLC MS/MS Ultrasonic Waves Validation Reg. 2002/657 EC Xenobiotics - analysis |
| title | Ultrasound assisted dispersive liquid-liquid microextraction for fast and accurate analysis of chloramphenicol in honey |
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