High-sensitivity cardiac troponin decrease after percutaneous coronary intervention in patients with stable coronary artery disease
Baseline cardiac troponin is a strong predictor of major adverse cardiac events (MACE), and the high sensitive assay can provide risk stratification under the 99th percentile values. Currently, prognostic benefit of PCI has not been established in patients with stable coronary artery disease (CAD),...
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| Veröffentlicht in: | Heart and vessels 2019-06, Vol.34 (6), p.948-956 |
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| creator | Hamaya, Rikuta Horie, Tomoki Yonetsu, Taishi Sugano, Akinori Kanaji, Yoshihisa Usui, Eisuke Hoshino, Masahiro Yamaguchi, Masao Ohya, Hiroaki Sumino, Yohei Hada, Masahiro Hirano, Hidenori Kanno, Yoshinori Yuki, Haruhito Hirao, Kenzo Kakuta, Tsunekazu |
| description | Baseline cardiac troponin is a strong predictor of major adverse cardiac events (MACE), and the high sensitive assay can provide risk stratification under the 99th percentile values. Currently, prognostic benefit of PCI has not been established in patients with stable coronary artery disease (CAD), and the influence on baseline troponin levels is unknown. This study aimed to investigate the impact of PCI on baseline high-sensitivity cardiac troponin-I (hs-cTnI) levels and the association with MACE incidence. For 401 patients with stable CAD who were indicated for PCI, baseline hs-cTnI levels were measured before PCI for two times (the average: pre-PCI hs-cTnI) and 10 months after PCI (post-PCI remote hs-cTnI). Hs-cTnI day-to-day variability was assessed based on the pre-PCI values and patients were divided into three groups (Increase/No change/Decrease group) according to the extent of hs-cTnI change (post-PCI remote hs-cTnI minus pre-PCI hs-cTnI) considering the day-to-day variability. A total of 77 patients were categorized into Decrease group. Although Decrease group had significantly higher pre-PCI hs-cTnI levels compared to the other groups, this group had lowest incidence of MACE (
p
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| doi_str_mv | 10.1007/s00380-018-01325-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2162773633</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2229250962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-9dcbf24dd51987f9f56196a84de8a5458d88abedc2c4e6826aad35266e28b183</originalsourceid><addsrcrecordid>eNp9kTtrHTEQhUVIiK-d_IEURpAmzSZ6rLRSGUxiGwxp3AutNGvL3CttJK3NrfPHLWf9ABcuhmGY7xxpOAh9oeQ7JWT4UQjhinSEqlaciU6-QxsqqeiYGPh7tCGakk5xNhygw1JuCKFCU_0RHXAim7bXG_TvLFxddwViCTXchrrHzmYfrMM1pznFELEHl8EWwHaqkPEM2S3VRkhLwS7lFG3e4xDb7hZiDSm2Ac-2hjYVfBfqNS7Vjlt4oW1u9B77UB6MP6EPk90W-PzYj9Dl71-XJ2fdxZ_T85OfF53jWtdOezdOrPdeUK2GSU9CUi2t6j0oK3qhvFJ2BO-Y60EqJq31XDApgamRKn6Evq22c05_FyjV7EJxsN2utxhGJRsGLjlv6NdX6E1acmyfM4wxzQTRkjWKrZTLqZQMk5lz2LX7DCXmISGzJmRaQuZ_QkY20fGj9TLuwD9LniJpAF-B0lbxCvLL22_Y3gOpPZ8t</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2229250962</pqid></control><display><type>article</type><title>High-sensitivity cardiac troponin decrease after percutaneous coronary intervention in patients with stable coronary artery disease</title><source>SpringerLink Journals</source><creator>Hamaya, Rikuta ; Horie, Tomoki ; Yonetsu, Taishi ; Sugano, Akinori ; Kanaji, Yoshihisa ; Usui, Eisuke ; Hoshino, Masahiro ; Yamaguchi, Masao ; Ohya, Hiroaki ; Sumino, Yohei ; Hada, Masahiro ; Hirano, Hidenori ; Kanno, Yoshinori ; Yuki, Haruhito ; Hirao, Kenzo ; Kakuta, Tsunekazu</creator><creatorcontrib>Hamaya, Rikuta ; Horie, Tomoki ; Yonetsu, Taishi ; Sugano, Akinori ; Kanaji, Yoshihisa ; Usui, Eisuke ; Hoshino, Masahiro ; Yamaguchi, Masao ; Ohya, Hiroaki ; Sumino, Yohei ; Hada, Masahiro ; Hirano, Hidenori ; Kanno, Yoshinori ; Yuki, Haruhito ; Hirao, Kenzo ; Kakuta, Tsunekazu</creatorcontrib><description>Baseline cardiac troponin is a strong predictor of major adverse cardiac events (MACE), and the high sensitive assay can provide risk stratification under the 99th percentile values. Currently, prognostic benefit of PCI has not been established in patients with stable coronary artery disease (CAD), and the influence on baseline troponin levels is unknown. This study aimed to investigate the impact of PCI on baseline high-sensitivity cardiac troponin-I (hs-cTnI) levels and the association with MACE incidence. For 401 patients with stable CAD who were indicated for PCI, baseline hs-cTnI levels were measured before PCI for two times (the average: pre-PCI hs-cTnI) and 10 months after PCI (post-PCI remote hs-cTnI). Hs-cTnI day-to-day variability was assessed based on the pre-PCI values and patients were divided into three groups (Increase/No change/Decrease group) according to the extent of hs-cTnI change (post-PCI remote hs-cTnI minus pre-PCI hs-cTnI) considering the day-to-day variability. A total of 77 patients were categorized into Decrease group. Although Decrease group had significantly higher pre-PCI hs-cTnI levels compared to the other groups, this group had lowest incidence of MACE (
p
< 0.001). Hs-cTnI changes were independently associated with MACE incidence after adjustment (HR 2.069, 95% CI 1.032–4.006,
p
= 0.041 for Increase group vs. No change group; HR 0.143, 95% CI 0.008–0.680,
p
= 0.009 for Decrease group vs. No change group). Hs-cTnI change following PCI was significantly predicted by pre-PCI hs-cTnI, hs-cTnI variability, the presence of dyslipidemia, multivessel disease, and lesions with chronic total occlusion or low quantitative flow ratio. In conclusion, PCI could lower hs-cTnI levels in a certain subset of patients, in whom prognostic benefit might be expected by the intervention.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-018-01325-6</identifier><identifier>PMID: 30600349</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Angioplasty ; Biomedical Engineering and Bioengineering ; Calcium-binding protein ; Cardiac Surgery ; Cardiology ; Cardiovascular disease ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Dyslipidemia ; Incidence ; Intervention ; Lesions ; Medicine ; Medicine & Public Health ; Occlusion ; Original Article ; Sensitivity ; Stents ; Troponin ; Variability ; Vascular Surgery</subject><ispartof>Heart and vessels, 2019-06, Vol.34 (6), p.948-956</ispartof><rights>Springer Japan KK, part of Springer Nature 2019</rights><rights>Springer Japan KK, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-9dcbf24dd51987f9f56196a84de8a5458d88abedc2c4e6826aad35266e28b183</citedby><cites>FETCH-LOGICAL-c399t-9dcbf24dd51987f9f56196a84de8a5458d88abedc2c4e6826aad35266e28b183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-018-01325-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-018-01325-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30600349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamaya, Rikuta</creatorcontrib><creatorcontrib>Horie, Tomoki</creatorcontrib><creatorcontrib>Yonetsu, Taishi</creatorcontrib><creatorcontrib>Sugano, Akinori</creatorcontrib><creatorcontrib>Kanaji, Yoshihisa</creatorcontrib><creatorcontrib>Usui, Eisuke</creatorcontrib><creatorcontrib>Hoshino, Masahiro</creatorcontrib><creatorcontrib>Yamaguchi, Masao</creatorcontrib><creatorcontrib>Ohya, Hiroaki</creatorcontrib><creatorcontrib>Sumino, Yohei</creatorcontrib><creatorcontrib>Hada, Masahiro</creatorcontrib><creatorcontrib>Hirano, Hidenori</creatorcontrib><creatorcontrib>Kanno, Yoshinori</creatorcontrib><creatorcontrib>Yuki, Haruhito</creatorcontrib><creatorcontrib>Hirao, Kenzo</creatorcontrib><creatorcontrib>Kakuta, Tsunekazu</creatorcontrib><title>High-sensitivity cardiac troponin decrease after percutaneous coronary intervention in patients with stable coronary artery disease</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>Baseline cardiac troponin is a strong predictor of major adverse cardiac events (MACE), and the high sensitive assay can provide risk stratification under the 99th percentile values. Currently, prognostic benefit of PCI has not been established in patients with stable coronary artery disease (CAD), and the influence on baseline troponin levels is unknown. This study aimed to investigate the impact of PCI on baseline high-sensitivity cardiac troponin-I (hs-cTnI) levels and the association with MACE incidence. For 401 patients with stable CAD who were indicated for PCI, baseline hs-cTnI levels were measured before PCI for two times (the average: pre-PCI hs-cTnI) and 10 months after PCI (post-PCI remote hs-cTnI). Hs-cTnI day-to-day variability was assessed based on the pre-PCI values and patients were divided into three groups (Increase/No change/Decrease group) according to the extent of hs-cTnI change (post-PCI remote hs-cTnI minus pre-PCI hs-cTnI) considering the day-to-day variability. A total of 77 patients were categorized into Decrease group. Although Decrease group had significantly higher pre-PCI hs-cTnI levels compared to the other groups, this group had lowest incidence of MACE (
p
< 0.001). Hs-cTnI changes were independently associated with MACE incidence after adjustment (HR 2.069, 95% CI 1.032–4.006,
p
= 0.041 for Increase group vs. No change group; HR 0.143, 95% CI 0.008–0.680,
p
= 0.009 for Decrease group vs. No change group). Hs-cTnI change following PCI was significantly predicted by pre-PCI hs-cTnI, hs-cTnI variability, the presence of dyslipidemia, multivessel disease, and lesions with chronic total occlusion or low quantitative flow ratio. In conclusion, PCI could lower hs-cTnI levels in a certain subset of patients, in whom prognostic benefit might be expected by the intervention.</description><subject>Angioplasty</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Calcium-binding protein</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Dyslipidemia</subject><subject>Incidence</subject><subject>Intervention</subject><subject>Lesions</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Occlusion</subject><subject>Original Article</subject><subject>Sensitivity</subject><subject>Stents</subject><subject>Troponin</subject><subject>Variability</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kTtrHTEQhUVIiK-d_IEURpAmzSZ6rLRSGUxiGwxp3AutNGvL3CttJK3NrfPHLWf9ABcuhmGY7xxpOAh9oeQ7JWT4UQjhinSEqlaciU6-QxsqqeiYGPh7tCGakk5xNhygw1JuCKFCU_0RHXAim7bXG_TvLFxddwViCTXchrrHzmYfrMM1pznFELEHl8EWwHaqkPEM2S3VRkhLwS7lFG3e4xDb7hZiDSm2Ac-2hjYVfBfqNS7Vjlt4oW1u9B77UB6MP6EPk90W-PzYj9Dl71-XJ2fdxZ_T85OfF53jWtdOezdOrPdeUK2GSU9CUi2t6j0oK3qhvFJ2BO-Y60EqJq31XDApgamRKn6Evq22c05_FyjV7EJxsN2utxhGJRsGLjlv6NdX6E1acmyfM4wxzQTRkjWKrZTLqZQMk5lz2LX7DCXmISGzJmRaQuZ_QkY20fGj9TLuwD9LniJpAF-B0lbxCvLL22_Y3gOpPZ8t</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Hamaya, Rikuta</creator><creator>Horie, Tomoki</creator><creator>Yonetsu, Taishi</creator><creator>Sugano, Akinori</creator><creator>Kanaji, Yoshihisa</creator><creator>Usui, Eisuke</creator><creator>Hoshino, Masahiro</creator><creator>Yamaguchi, Masao</creator><creator>Ohya, Hiroaki</creator><creator>Sumino, Yohei</creator><creator>Hada, Masahiro</creator><creator>Hirano, Hidenori</creator><creator>Kanno, Yoshinori</creator><creator>Yuki, Haruhito</creator><creator>Hirao, Kenzo</creator><creator>Kakuta, Tsunekazu</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>High-sensitivity cardiac troponin decrease after percutaneous coronary intervention in patients with stable coronary artery disease</title><author>Hamaya, Rikuta ; Horie, Tomoki ; Yonetsu, Taishi ; Sugano, Akinori ; Kanaji, Yoshihisa ; Usui, Eisuke ; Hoshino, Masahiro ; Yamaguchi, Masao ; Ohya, Hiroaki ; Sumino, Yohei ; Hada, Masahiro ; Hirano, Hidenori ; Kanno, Yoshinori ; Yuki, Haruhito ; Hirao, Kenzo ; Kakuta, Tsunekazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-9dcbf24dd51987f9f56196a84de8a5458d88abedc2c4e6826aad35266e28b183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angioplasty</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Calcium-binding protein</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary vessels</topic><topic>Dyslipidemia</topic><topic>Incidence</topic><topic>Intervention</topic><topic>Lesions</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Occlusion</topic><topic>Original Article</topic><topic>Sensitivity</topic><topic>Stents</topic><topic>Troponin</topic><topic>Variability</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamaya, Rikuta</creatorcontrib><creatorcontrib>Horie, Tomoki</creatorcontrib><creatorcontrib>Yonetsu, Taishi</creatorcontrib><creatorcontrib>Sugano, Akinori</creatorcontrib><creatorcontrib>Kanaji, Yoshihisa</creatorcontrib><creatorcontrib>Usui, Eisuke</creatorcontrib><creatorcontrib>Hoshino, Masahiro</creatorcontrib><creatorcontrib>Yamaguchi, Masao</creatorcontrib><creatorcontrib>Ohya, Hiroaki</creatorcontrib><creatorcontrib>Sumino, Yohei</creatorcontrib><creatorcontrib>Hada, Masahiro</creatorcontrib><creatorcontrib>Hirano, Hidenori</creatorcontrib><creatorcontrib>Kanno, Yoshinori</creatorcontrib><creatorcontrib>Yuki, Haruhito</creatorcontrib><creatorcontrib>Hirao, Kenzo</creatorcontrib><creatorcontrib>Kakuta, Tsunekazu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamaya, Rikuta</au><au>Horie, Tomoki</au><au>Yonetsu, Taishi</au><au>Sugano, Akinori</au><au>Kanaji, Yoshihisa</au><au>Usui, Eisuke</au><au>Hoshino, Masahiro</au><au>Yamaguchi, Masao</au><au>Ohya, Hiroaki</au><au>Sumino, Yohei</au><au>Hada, Masahiro</au><au>Hirano, Hidenori</au><au>Kanno, Yoshinori</au><au>Yuki, Haruhito</au><au>Hirao, Kenzo</au><au>Kakuta, Tsunekazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-sensitivity cardiac troponin decrease after percutaneous coronary intervention in patients with stable coronary artery disease</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>34</volume><issue>6</issue><spage>948</spage><epage>956</epage><pages>948-956</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>Baseline cardiac troponin is a strong predictor of major adverse cardiac events (MACE), and the high sensitive assay can provide risk stratification under the 99th percentile values. Currently, prognostic benefit of PCI has not been established in patients with stable coronary artery disease (CAD), and the influence on baseline troponin levels is unknown. This study aimed to investigate the impact of PCI on baseline high-sensitivity cardiac troponin-I (hs-cTnI) levels and the association with MACE incidence. For 401 patients with stable CAD who were indicated for PCI, baseline hs-cTnI levels were measured before PCI for two times (the average: pre-PCI hs-cTnI) and 10 months after PCI (post-PCI remote hs-cTnI). Hs-cTnI day-to-day variability was assessed based on the pre-PCI values and patients were divided into three groups (Increase/No change/Decrease group) according to the extent of hs-cTnI change (post-PCI remote hs-cTnI minus pre-PCI hs-cTnI) considering the day-to-day variability. A total of 77 patients were categorized into Decrease group. Although Decrease group had significantly higher pre-PCI hs-cTnI levels compared to the other groups, this group had lowest incidence of MACE (
p
< 0.001). Hs-cTnI changes were independently associated with MACE incidence after adjustment (HR 2.069, 95% CI 1.032–4.006,
p
= 0.041 for Increase group vs. No change group; HR 0.143, 95% CI 0.008–0.680,
p
= 0.009 for Decrease group vs. No change group). Hs-cTnI change following PCI was significantly predicted by pre-PCI hs-cTnI, hs-cTnI variability, the presence of dyslipidemia, multivessel disease, and lesions with chronic total occlusion or low quantitative flow ratio. In conclusion, PCI could lower hs-cTnI levels in a certain subset of patients, in whom prognostic benefit might be expected by the intervention.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>30600349</pmid><doi>10.1007/s00380-018-01325-6</doi><tpages>9</tpages></addata></record> |
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| subjects | Angioplasty Biomedical Engineering and Bioengineering Calcium-binding protein Cardiac Surgery Cardiology Cardiovascular disease Coronary artery Coronary artery disease Coronary vessels Dyslipidemia Incidence Intervention Lesions Medicine Medicine & Public Health Occlusion Original Article Sensitivity Stents Troponin Variability Vascular Surgery |
| title | High-sensitivity cardiac troponin decrease after percutaneous coronary intervention in patients with stable coronary artery disease |
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