Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

Background To evaluate the prognostic significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma (HNSCC). Material and methods We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta‐analysis to quantify the impact of...

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Veröffentlicht in:	Head & neck 2019-06, Vol.41 (6), p.1963-1978
Hauptverfasser:	Ramos‐García, Pablo, González‐Moles, Miguel Ángel, Ayén, Ángela, González‐Ruiz, Lucía, Ruiz‐Ávila, Isabel, Gil‐Montoya, José Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	cortactin CTTN Head & neck cancer head and neck cancer Medical prognosis Meta-analysis prognosis Squamous cell carcinoma
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Zusammenfassung:	Background To evaluate the prognostic significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma (HNSCC). Material and methods We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta‐analysis to quantify the impact of CTTN/cortactin alterations on clinicopathological and survival variables. Results Eighteen studies (1633 patients) met inclusion criteria. Quantitative evaluation revealed a strong association of CTTN/cortactin alterations with N+ status (P
ISSN:	1043-3074 1097-0347
DOI:	10.1002/hed.25632