Kaempferol protects mice from d-GalN/LPS-induced acute liver failure by regulating the ER stress-Grp78-CHOP signaling pathway

Kaempferol is a flavonoid compound that has many functions, such as anti-inflammation and antioxidation. Acute liver failure (ALF) is a life-threatening illness accompanied by serious inflammation and extensive hepatocyte apoptosis. The aim of this study was to examine the therapeutic potential of k...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-03, Vol.111, p.468-475
Hauptverfasser:	Wang, Huijuan, Chen, Liyan, Zhang, Xiangying, Xu, Lin, Xie, Bangxiang, Shi, Hongbo, Duan, Zhongping, Zhang, Huanhu, Ren, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute liver failure Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Cells, Cultured CHOP Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - physiology ER stress Galactosamine - toxicity Grp78 Heat-Shock Proteins - agonists Heat-Shock Proteins - biosynthesis Hepatocytes - drug effects Hepatocytes - metabolism Kaempferol Kaempferols - pharmacology Kaempferols - therapeutic use Lipopolysaccharides - toxicity Liver Failure, Acute - chemically induced Liver Failure, Acute - metabolism Liver Failure, Acute - prevention & control Male Mice Mice, Inbred C57BL Signal Transduction - drug effects Signal Transduction - physiology Transcription Factor CHOP - antagonists & inhibitors Transcription Factor CHOP - biosynthesis
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