Novel Light/Dark Regimens with Minimum Light Promote Circadian Disruption: Simulations with a Model Oscillator
Artificial lab manipulation of LD cycles has enabled simulations of the disruptive conditions found in modern human societies, such as jet-lag, night-work and light at night. New techniques using animal models have been developed, and these can greatly improve our understanding of circadian disrupti...
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Veröffentlicht in: | Journal of biological rhythms 2019-02, Vol.34 (1), p.105-110 |
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description | Artificial lab manipulation of LD cycles has enabled simulations of the disruptive conditions found in modern human societies, such as jet-lag, night-work and light at night. New techniques using animal models have been developed, and these can greatly improve our understanding of circadian disruption. Some of these techniques, such as in vivo bioluminescence assays, require minimum external light. This requirement is challenging because the usual lighting protocols applied in circadian desynchronization experiments rely on considerable light input. Here, we present a novel LD regimen that can disrupt circadian rhythms with little light per day, based on computer simulations of a model limit-cycle oscillator. The model predicts that a single light pulse per day has the potential to disturb rhythmicity when pulse times are randomly distributed within an interval. Counterintuitively, the rhythm still preserves an underlying 24-h periodicity when this interval is as large as 14 h, indicating that day/night cues are still detectable. Only when pulses are spread throughout the whole 24-h day does the rhythm lose any day-to-day period correlation. In addition, the model also reveals that stronger pulses of brighter light should exacerbate the disrupting effects. We propose the use of this LD schedule—which would be compatible with the requirements of in vivo bioluminescence assays—to help understand circadian disruption and associated illnesses. |
doi_str_mv | 10.1177/0748730418820727 |
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Counterintuitively, the rhythm still preserves an underlying 24-h periodicity when this interval is as large as 14 h, indicating that day/night cues are still detectable. Only when pulses are spread throughout the whole 24-h day does the rhythm lose any day-to-day period correlation. In addition, the model also reveals that stronger pulses of brighter light should exacerbate the disrupting effects. 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F. L.</creatorcontrib><creatorcontrib>Oda, Gisele A.</creatorcontrib><title>Novel Light/Dark Regimens with Minimum Light Promote Circadian Disruption: Simulations with a Model Oscillator</title><title>Journal of biological rhythms</title><addtitle>J Biol Rhythms</addtitle><description>Artificial lab manipulation of LD cycles has enabled simulations of the disruptive conditions found in modern human societies, such as jet-lag, night-work and light at night. New techniques using animal models have been developed, and these can greatly improve our understanding of circadian disruption. Some of these techniques, such as in vivo bioluminescence assays, require minimum external light. This requirement is challenging because the usual lighting protocols applied in circadian desynchronization experiments rely on considerable light input. Here, we present a novel LD regimen that can disrupt circadian rhythms with little light per day, based on computer simulations of a model limit-cycle oscillator. The model predicts that a single light pulse per day has the potential to disturb rhythmicity when pulse times are randomly distributed within an interval. Counterintuitively, the rhythm still preserves an underlying 24-h periodicity when this interval is as large as 14 h, indicating that day/night cues are still detectable. Only when pulses are spread throughout the whole 24-h day does the rhythm lose any day-to-day period correlation. In addition, the model also reveals that stronger pulses of brighter light should exacerbate the disrupting effects. We propose the use of this LD schedule—which would be compatible with the requirements of in vivo bioluminescence assays—to help understand circadian disruption and associated illnesses.</description><subject>Animal models</subject><subject>Animals</subject><subject>Bioluminescence</subject><subject>Circadian Rhythm - radiation effects</subject><subject>Circadian rhythms</subject><subject>Computer Simulation</subject><subject>Disruption</subject><subject>Humans</subject><subject>Illnesses</subject><subject>In vivo methods and tests</subject><subject>Jet Lag Syndrome</subject><subject>Light</subject><subject>Lighting</subject><subject>Mathematical models</subject><subject>Models, Theoretical</subject><subject>Night</subject><subject>Periodicity</subject><subject>Photoperiod</subject><subject>Protocol (computers)</subject><subject>Rhythm</subject><subject>Schedules</subject><subject>Shift Work Schedule</subject><subject>Synchronization</subject><issn>0748-7304</issn><issn>1552-4531</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctLAzEQxoMoWqt3TxLw4mV1kk02WW_S-oL6wMd5SbNpm9rd1GRX8b83S6uC4GkGvt_3zTCD0AGBE0KEOAXBpEiBESkpCCo2UI9wThPGU7KJep2cdPoO2g1hDgBZztJttJMCzzkI0UP1nXs3Czyy01lzOlT-FT-aqa1MHfCHbWb41ta2aqsVgB-8q1xj8MB6rUqrajy0wbfLxrr6DD9FcqG6fm1W-NaVMf0-aLuIivN7aGuiFsHsr2sfvVxePA-uk9H91c3gfJRoBqJJpM6B6AkDJXMlDBjDGaVMZ2IyFpwREGWaMT2WJheSkpyxMSuJypQkhGclpH10vMpdevfWmtAUlQ3axCVq49pQUJKRnPJIR_ToDzp3ra_jdpGSwGiW0Y6CFaW9C8GbSbH0tlL-syBQdL8o_v4iWg7Xwe24MuWP4fv4EUhWQFBT8zv138AvynWPuQ</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Flôres, Danilo E. F. L.</creator><creator>Oda, Gisele A.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>Novel Light/Dark Regimens with Minimum Light Promote Circadian Disruption: Simulations with a Model Oscillator</title><author>Flôres, Danilo E. F. L. ; Oda, Gisele A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-8c901cf40a89a7e0ee54224c67fb754107d364cb8e97821944b4d1a6a81156d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Bioluminescence</topic><topic>Circadian Rhythm - radiation effects</topic><topic>Circadian rhythms</topic><topic>Computer Simulation</topic><topic>Disruption</topic><topic>Humans</topic><topic>Illnesses</topic><topic>In vivo methods and tests</topic><topic>Jet Lag Syndrome</topic><topic>Light</topic><topic>Lighting</topic><topic>Mathematical models</topic><topic>Models, Theoretical</topic><topic>Night</topic><topic>Periodicity</topic><topic>Photoperiod</topic><topic>Protocol (computers)</topic><topic>Rhythm</topic><topic>Schedules</topic><topic>Shift Work Schedule</topic><topic>Synchronization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flôres, Danilo E. 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subjects | Animal models Animals Bioluminescence Circadian Rhythm - radiation effects Circadian rhythms Computer Simulation Disruption Humans Illnesses In vivo methods and tests Jet Lag Syndrome Light Lighting Mathematical models Models, Theoretical Night Periodicity Photoperiod Protocol (computers) Rhythm Schedules Shift Work Schedule Synchronization |
title | Novel Light/Dark Regimens with Minimum Light Promote Circadian Disruption: Simulations with a Model Oscillator |
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