The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat

Objectives To study the antinociceptive effect of single and repeated doses of resveratrol in a bone cancer pain model, and whether this effect is prevented by the Silent Information Regulator 1 (SIRT1) inhibitor selisistat. Methods The femoral intercondylar bone of BALB/c mice was injected with 1 0...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2019-05, Vol.71 (5), p.816-825
Hauptverfasser:	Lux, Sebastian, Lobos, Nicolas, Lespay‐Rebolledo, Carolyne, Salas‐Huenuleo, Edison, Kogan, Marcelo J., Flores, Christian, Pinto, Mauricio, Hernandez, Alejandro, Pelissier, Teresa, Constandil, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone cancer Bone mass Bone resorption cancer pain Femur Fluorescence Hyperalgesia Metastases mice Pain Pain perception Resveratrol selisistat Silent Information Regulator 1 SIRT1 protein Tumors
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