Brefeldin A–sensitive ER‐Golgi vesicle trafficking contributes to NLRP3‐dependent caspase‐1 activation

ABSTRACT Endoplasmic reticulum (ER)‐Golgi vesicle trafficking plays a pivotal role in the conventional secretory pathway of many cytokines; however, the precise release mechanism of a major inflammasome mediator, IL‐1β, is not thought to follow the conventional ER‐Golgi route and remains elusive. He...

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Veröffentlicht in:	The FASEB journal 2019-03, Vol.33 (3), p.4547-4558
Hauptverfasser:	Hong, Sujeong, Hwang, Inhwa, Gim, Eunji, Yang, Jungmin, Park, Sangjun, Yoon, Sung-Hyun, Lee, Won-Woo, Yu, Je-Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals BFA BIG1 Brefeldin A - pharmacology Caspase 1 - metabolism Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Enzyme Activation - drug effects Golgi Apparatus - drug effects Golgi Apparatus - metabolism Guanine Nucleotide Exchange Factors - antagonists & inhibitors Guanine Nucleotide Exchange Factors - deficiency Guanine Nucleotide Exchange Factors - metabolism Humans IL-1β secretion inflammasome Inflammasomes - drug effects Inflammasomes - physiology Interleukin-1beta - biosynthesis Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - drug effects Mitochondria - ultrastructure NLR Family, Pyrin Domain-Containing 3 Protein - deficiency NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - physiology Potassium - metabolism Protein Transport - drug effects Specific Pathogen-Free Organisms THP-1 Cells
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