Effects of a roughened femoral head and the locus of grafting on the wear resistance of the phospholipid polymer-grafted acetabular liner
[Display omitted] Although laboratory tests and mid-term clinical outcomes show the clinical safety and remarkable wear resistance of the highly cross-linked polyethylene (HXLPE) acetabular liner with a nanometer-scaled graft layer of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), the wear r...
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Veröffentlicht in: | Acta biomaterialia 2019-03, Vol.86, p.338-349 |
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creator | Moro, Toru Ishihara, Kazuhiko Takatori, Yoshio Tanaka, Sakae Kyomoto, Masayuki Hashimoto, Masami Ishikura, Hisatoshi Hidaka, Ryo Tanaka, Takeyuki Kawaguchi, Hiroshi Nakamura, Kozo |
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Although laboratory tests and mid-term clinical outcomes show the clinical safety and remarkable wear resistance of the highly cross-linked polyethylene (HXLPE) acetabular liner with a nanometer-scaled graft layer of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), the wear resistance of the layer under severe abrasive conditions is concerning. We evaluated the effects of a roughened femoral head and the grafting locus on the wear resistance of the PMPC-grafted HXLPE liner and the effect of PMPC grafting on wear resistance of the HXLPE substrate by removing the PMPC-grafted layer using a severely roughened femoral head. Against a moderately roughened femoral head, the PMPC-grafted HXLPE liner showed negative wear, although an untreated HXLPE liner increased the wear by 154.1% compared with wear against a polished femoral head, confirming that PMPC grafts were unaffected. Against a severely roughened femoral head, the PMPC-grafted layer of the head contact area might be removed under severe conditions. However, the wear rate was reduced by 52.5% compared to that of untreated HXLPE liners. Moreover, the head non-contact area-modified PMPC-grafted HXLPE liner against a polished femoral head reduced the wear by 76.8% compared with untreated HXLPE liner; thus, this area may be also important in the development of fluid-film lubrication.
Here we describe effects of a roughened femoral head and the locus of grafting on the wear-resistance of the phospholipid polymer grafted highly cross-linked polyethylene (PMPC-HXLPE) liner. Against a moderately roughened femoral head, the PMPC-HXLPE liner showed negative wear, confirming that PMPC grafts were unaffected. After removing the PMPC layer of the head contact area using a severely roughened femoral head, the wear rate not only exceeded that of untreated HXLPE liners, but was reduced by 52.5%, confirming that PMPC grafting does not affect the wear-resistance of the HXLPE substrate. In addition, the head non-contact area-modified PMPC-HXLPE liner reduced the wear by 76.8%. Thus, this area may also may be important in the development of fluid-film lubrication. |
doi_str_mv | 10.1016/j.actbio.2018.12.025 |
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Although laboratory tests and mid-term clinical outcomes show the clinical safety and remarkable wear resistance of the highly cross-linked polyethylene (HXLPE) acetabular liner with a nanometer-scaled graft layer of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), the wear resistance of the layer under severe abrasive conditions is concerning. We evaluated the effects of a roughened femoral head and the grafting locus on the wear resistance of the PMPC-grafted HXLPE liner and the effect of PMPC grafting on wear resistance of the HXLPE substrate by removing the PMPC-grafted layer using a severely roughened femoral head. Against a moderately roughened femoral head, the PMPC-grafted HXLPE liner showed negative wear, although an untreated HXLPE liner increased the wear by 154.1% compared with wear against a polished femoral head, confirming that PMPC grafts were unaffected. Against a severely roughened femoral head, the PMPC-grafted layer of the head contact area might be removed under severe conditions. However, the wear rate was reduced by 52.5% compared to that of untreated HXLPE liners. Moreover, the head non-contact area-modified PMPC-grafted HXLPE liner against a polished femoral head reduced the wear by 76.8% compared with untreated HXLPE liner; thus, this area may be also important in the development of fluid-film lubrication.
Here we describe effects of a roughened femoral head and the locus of grafting on the wear-resistance of the phospholipid polymer grafted highly cross-linked polyethylene (PMPC-HXLPE) liner. Against a moderately roughened femoral head, the PMPC-HXLPE liner showed negative wear, confirming that PMPC grafts were unaffected. After removing the PMPC layer of the head contact area using a severely roughened femoral head, the wear rate not only exceeded that of untreated HXLPE liners, but was reduced by 52.5%, confirming that PMPC grafting does not affect the wear-resistance of the HXLPE substrate. In addition, the head non-contact area-modified PMPC-HXLPE liner reduced the wear by 76.8%. Thus, this area may also may be important in the development of fluid-film lubrication.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2018.12.025</identifier><identifier>PMID: 30590185</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Abrasive wear ; Acetabulum ; Acetabulum - physiology ; Arthroplasty ; Cross-linked polyethylene ; Cross-Linking Reagents - chemistry ; Femur ; Femur Head - transplantation ; Grafting ; Grafts ; Humans ; Joint replacement ; Laboratory tests ; Linings ; Loci ; Lubrication ; Methacrylates - chemistry ; Methacryloyloxyethyl phosphorylcholine ; Phospholipids ; Phosphorylcholine ; Phosphorylcholine - analogs & derivatives ; Phosphorylcholine - chemistry ; Polyethylene ; Polyethylene - chemistry ; Polymers - chemistry ; Roughened head ; Substrates ; Wear rate ; Wear resistance</subject><ispartof>Acta biomaterialia, 2019-03, Vol.86, p.338-349</ispartof><rights>2018 Acta Materialia Inc.</rights><rights>Copyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Mar 1, 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-5be945fef6c249dacb96e505d2601cd0c2335308046851d63d3b15d21830d44a3</citedby><cites>FETCH-LOGICAL-c456t-5be945fef6c249dacb96e505d2601cd0c2335308046851d63d3b15d21830d44a3</cites><orcidid>0000-0001-9210-9414 ; 0000-0002-7448-5237 ; 0000-0002-4196-5488</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2018.12.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30590185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moro, Toru</creatorcontrib><creatorcontrib>Ishihara, Kazuhiko</creatorcontrib><creatorcontrib>Takatori, Yoshio</creatorcontrib><creatorcontrib>Tanaka, Sakae</creatorcontrib><creatorcontrib>Kyomoto, Masayuki</creatorcontrib><creatorcontrib>Hashimoto, Masami</creatorcontrib><creatorcontrib>Ishikura, Hisatoshi</creatorcontrib><creatorcontrib>Hidaka, Ryo</creatorcontrib><creatorcontrib>Tanaka, Takeyuki</creatorcontrib><creatorcontrib>Kawaguchi, Hiroshi</creatorcontrib><creatorcontrib>Nakamura, Kozo</creatorcontrib><title>Effects of a roughened femoral head and the locus of grafting on the wear resistance of the phospholipid polymer-grafted acetabular liner</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
Although laboratory tests and mid-term clinical outcomes show the clinical safety and remarkable wear resistance of the highly cross-linked polyethylene (HXLPE) acetabular liner with a nanometer-scaled graft layer of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), the wear resistance of the layer under severe abrasive conditions is concerning. We evaluated the effects of a roughened femoral head and the grafting locus on the wear resistance of the PMPC-grafted HXLPE liner and the effect of PMPC grafting on wear resistance of the HXLPE substrate by removing the PMPC-grafted layer using a severely roughened femoral head. Against a moderately roughened femoral head, the PMPC-grafted HXLPE liner showed negative wear, although an untreated HXLPE liner increased the wear by 154.1% compared with wear against a polished femoral head, confirming that PMPC grafts were unaffected. Against a severely roughened femoral head, the PMPC-grafted layer of the head contact area might be removed under severe conditions. However, the wear rate was reduced by 52.5% compared to that of untreated HXLPE liners. Moreover, the head non-contact area-modified PMPC-grafted HXLPE liner against a polished femoral head reduced the wear by 76.8% compared with untreated HXLPE liner; thus, this area may be also important in the development of fluid-film lubrication.
Here we describe effects of a roughened femoral head and the locus of grafting on the wear-resistance of the phospholipid polymer grafted highly cross-linked polyethylene (PMPC-HXLPE) liner. Against a moderately roughened femoral head, the PMPC-HXLPE liner showed negative wear, confirming that PMPC grafts were unaffected. After removing the PMPC layer of the head contact area using a severely roughened femoral head, the wear rate not only exceeded that of untreated HXLPE liners, but was reduced by 52.5%, confirming that PMPC grafting does not affect the wear-resistance of the HXLPE substrate. In addition, the head non-contact area-modified PMPC-HXLPE liner reduced the wear by 76.8%. Thus, this area may also may be important in the development of fluid-film lubrication.</description><subject>Abrasive wear</subject><subject>Acetabulum</subject><subject>Acetabulum - physiology</subject><subject>Arthroplasty</subject><subject>Cross-linked polyethylene</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Femur</subject><subject>Femur Head - transplantation</subject><subject>Grafting</subject><subject>Grafts</subject><subject>Humans</subject><subject>Joint replacement</subject><subject>Laboratory tests</subject><subject>Linings</subject><subject>Loci</subject><subject>Lubrication</subject><subject>Methacrylates - chemistry</subject><subject>Methacryloyloxyethyl phosphorylcholine</subject><subject>Phospholipids</subject><subject>Phosphorylcholine</subject><subject>Phosphorylcholine - analogs & derivatives</subject><subject>Phosphorylcholine - chemistry</subject><subject>Polyethylene</subject><subject>Polyethylene - chemistry</subject><subject>Polymers - chemistry</subject><subject>Roughened head</subject><subject>Substrates</subject><subject>Wear rate</subject><subject>Wear resistance</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7jr6D0QCXrx0m-9OXwRZ1g9Y8KLnkE4qMxm6O23SrexP8F-bmVk9eBBSJFQ9b1WoF6GXlLSUUPX22Fq3DjG1jFDdUtYSJh-ha6o73XRS6cf13QnWdETRK_SslCMhXFOmn6IrTmRfVfIa_boNAdxacArY4py2_QFm8DjAlLId8QGsx3b2eD0AHpPbzuQ-27DGeY_TfC78BJtxhhLLamcHJ-SUXg6p1BjjEj1e0ng_QW7O2jrBOljtsI1VOcYZ8nP0JNixwIuHe4e-fbj9evOpufvy8fPN-7vGCanWRg7QCxkgKMdE760begWSSM8Uoc4TxziXnGgilJbUK-75QGuVak68EJbv0JtL3yWn7xuU1UyxOBhHO0PaimFU0Y5QofqKvv4HPaYtz_V3leopF-ezQ-JCuZxKyRDMkuNk872hxJysMkdzscqcrDKUmWpVlb16aL4NE_i_oj_eVODdBYC6jR8RsikuQl2vj7laZnyK_5_wG5EQpzA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Moro, Toru</creator><creator>Ishihara, Kazuhiko</creator><creator>Takatori, Yoshio</creator><creator>Tanaka, Sakae</creator><creator>Kyomoto, Masayuki</creator><creator>Hashimoto, Masami</creator><creator>Ishikura, Hisatoshi</creator><creator>Hidaka, Ryo</creator><creator>Tanaka, Takeyuki</creator><creator>Kawaguchi, Hiroshi</creator><creator>Nakamura, Kozo</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9210-9414</orcidid><orcidid>https://orcid.org/0000-0002-7448-5237</orcidid><orcidid>https://orcid.org/0000-0002-4196-5488</orcidid></search><sort><creationdate>20190301</creationdate><title>Effects of a roughened femoral head and the locus of grafting on the wear resistance of the phospholipid polymer-grafted acetabular liner</title><author>Moro, Toru ; Ishihara, Kazuhiko ; Takatori, Yoshio ; Tanaka, Sakae ; Kyomoto, Masayuki ; Hashimoto, Masami ; Ishikura, Hisatoshi ; Hidaka, Ryo ; Tanaka, Takeyuki ; Kawaguchi, Hiroshi ; Nakamura, Kozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-5be945fef6c249dacb96e505d2601cd0c2335308046851d63d3b15d21830d44a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abrasive wear</topic><topic>Acetabulum</topic><topic>Acetabulum - physiology</topic><topic>Arthroplasty</topic><topic>Cross-linked polyethylene</topic><topic>Cross-Linking Reagents - chemistry</topic><topic>Femur</topic><topic>Femur Head - transplantation</topic><topic>Grafting</topic><topic>Grafts</topic><topic>Humans</topic><topic>Joint replacement</topic><topic>Laboratory tests</topic><topic>Linings</topic><topic>Loci</topic><topic>Lubrication</topic><topic>Methacrylates - chemistry</topic><topic>Methacryloyloxyethyl phosphorylcholine</topic><topic>Phospholipids</topic><topic>Phosphorylcholine</topic><topic>Phosphorylcholine - analogs & derivatives</topic><topic>Phosphorylcholine - chemistry</topic><topic>Polyethylene</topic><topic>Polyethylene - chemistry</topic><topic>Polymers - chemistry</topic><topic>Roughened head</topic><topic>Substrates</topic><topic>Wear rate</topic><topic>Wear resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moro, Toru</creatorcontrib><creatorcontrib>Ishihara, Kazuhiko</creatorcontrib><creatorcontrib>Takatori, Yoshio</creatorcontrib><creatorcontrib>Tanaka, Sakae</creatorcontrib><creatorcontrib>Kyomoto, Masayuki</creatorcontrib><creatorcontrib>Hashimoto, Masami</creatorcontrib><creatorcontrib>Ishikura, Hisatoshi</creatorcontrib><creatorcontrib>Hidaka, Ryo</creatorcontrib><creatorcontrib>Tanaka, Takeyuki</creatorcontrib><creatorcontrib>Kawaguchi, Hiroshi</creatorcontrib><creatorcontrib>Nakamura, Kozo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moro, Toru</au><au>Ishihara, Kazuhiko</au><au>Takatori, Yoshio</au><au>Tanaka, Sakae</au><au>Kyomoto, Masayuki</au><au>Hashimoto, Masami</au><au>Ishikura, Hisatoshi</au><au>Hidaka, Ryo</au><au>Tanaka, Takeyuki</au><au>Kawaguchi, Hiroshi</au><au>Nakamura, Kozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a roughened femoral head and the locus of grafting on the wear resistance of the phospholipid polymer-grafted acetabular liner</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>86</volume><spage>338</spage><epage>349</epage><pages>338-349</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
Although laboratory tests and mid-term clinical outcomes show the clinical safety and remarkable wear resistance of the highly cross-linked polyethylene (HXLPE) acetabular liner with a nanometer-scaled graft layer of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), the wear resistance of the layer under severe abrasive conditions is concerning. We evaluated the effects of a roughened femoral head and the grafting locus on the wear resistance of the PMPC-grafted HXLPE liner and the effect of PMPC grafting on wear resistance of the HXLPE substrate by removing the PMPC-grafted layer using a severely roughened femoral head. Against a moderately roughened femoral head, the PMPC-grafted HXLPE liner showed negative wear, although an untreated HXLPE liner increased the wear by 154.1% compared with wear against a polished femoral head, confirming that PMPC grafts were unaffected. Against a severely roughened femoral head, the PMPC-grafted layer of the head contact area might be removed under severe conditions. However, the wear rate was reduced by 52.5% compared to that of untreated HXLPE liners. Moreover, the head non-contact area-modified PMPC-grafted HXLPE liner against a polished femoral head reduced the wear by 76.8% compared with untreated HXLPE liner; thus, this area may be also important in the development of fluid-film lubrication.
Here we describe effects of a roughened femoral head and the locus of grafting on the wear-resistance of the phospholipid polymer grafted highly cross-linked polyethylene (PMPC-HXLPE) liner. Against a moderately roughened femoral head, the PMPC-HXLPE liner showed negative wear, confirming that PMPC grafts were unaffected. After removing the PMPC layer of the head contact area using a severely roughened femoral head, the wear rate not only exceeded that of untreated HXLPE liners, but was reduced by 52.5%, confirming that PMPC grafting does not affect the wear-resistance of the HXLPE substrate. In addition, the head non-contact area-modified PMPC-HXLPE liner reduced the wear by 76.8%. Thus, this area may also may be important in the development of fluid-film lubrication.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30590185</pmid><doi>10.1016/j.actbio.2018.12.025</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9210-9414</orcidid><orcidid>https://orcid.org/0000-0002-7448-5237</orcidid><orcidid>https://orcid.org/0000-0002-4196-5488</orcidid></addata></record> |
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subjects | Abrasive wear Acetabulum Acetabulum - physiology Arthroplasty Cross-linked polyethylene Cross-Linking Reagents - chemistry Femur Femur Head - transplantation Grafting Grafts Humans Joint replacement Laboratory tests Linings Loci Lubrication Methacrylates - chemistry Methacryloyloxyethyl phosphorylcholine Phospholipids Phosphorylcholine Phosphorylcholine - analogs & derivatives Phosphorylcholine - chemistry Polyethylene Polyethylene - chemistry Polymers - chemistry Roughened head Substrates Wear rate Wear resistance |
title | Effects of a roughened femoral head and the locus of grafting on the wear resistance of the phospholipid polymer-grafted acetabular liner |
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