The endothelial status reflected by circulating endothelial cells, circulating endothelial progenitor cells and soluble thrombomodulin in patients with mild and resistant hypertension
The aim of the present study was to evaluate endothelial status by measuring the concentration of novel markers of endothelial dysfunction (ED): a number of circulating endothelial cells (CECs), circulating endothelial progenitor cells (CEPCs) and their ratio (CEPCs/CECs) as well as a traditional pa...
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| Veröffentlicht in: | Vascular pharmacology 2019-02, Vol.113, p.77-85 |
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| creator | Budzyń, Magdalena Gryszczyńska, Bogna Boruczkowski, Maciej Kaczmarek, Mariusz Begier-Krasińska, Beata Osińska, Angelika Bukowska, Alicja Iskra, Maria Kasprzak, Magdalena Paulina |
| description | The aim of the present study was to evaluate endothelial status by measuring the concentration of novel markers of endothelial dysfunction (ED): a number of circulating endothelial cells (CECs), circulating endothelial progenitor cells (CEPCs) and their ratio (CEPCs/CECs) as well as a traditional parameter - soluble thrombomodulin (sTM) in patients with resistant (RH) and mild hypertension (MH).
Thirty patients with MH and thirty subjects with RH were involved in the study. The control group included thirty-three age and sex-matched normotensive volunteers. We used multicolor flow cytometry for CECs and CEPCs analysis and the commercial human sTM ELISA kit to measure plasma sTM concentration.
An elevated CECs number and a decreased CEPCs/CECs ratio was found in MH as well as in RH patients in comparison with normotensive volunteers. CECs correlated positively with an increased triglycerides in MH patients and an elevated LDL-cholesterol and hsCRP in RH group. Positive correlation between CEPCs and LDL-cholesterol level was observed in both types of hypertension.
The results of the present study suggest that an endothelial alteration accompanies hypertension. The number of CECs reflecting the extent of endothelial damage does not appear to be related to the severity of disease. The drastically decreased ratio between CEPCs and CECs observed in both groups of patients suggests an inadequate process of endothelial regeneration. Among analyzed factors inflammation and lipid abnormalities may have significant contribution in endothelial pathology in hypertension.
[Display omitted] |
| doi_str_mv | 10.1016/j.vph.2018.12.005 |
| format | Article |
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Thirty patients with MH and thirty subjects with RH were involved in the study. The control group included thirty-three age and sex-matched normotensive volunteers. We used multicolor flow cytometry for CECs and CEPCs analysis and the commercial human sTM ELISA kit to measure plasma sTM concentration.
An elevated CECs number and a decreased CEPCs/CECs ratio was found in MH as well as in RH patients in comparison with normotensive volunteers. CECs correlated positively with an increased triglycerides in MH patients and an elevated LDL-cholesterol and hsCRP in RH group. Positive correlation between CEPCs and LDL-cholesterol level was observed in both types of hypertension.
The results of the present study suggest that an endothelial alteration accompanies hypertension. The number of CECs reflecting the extent of endothelial damage does not appear to be related to the severity of disease. The drastically decreased ratio between CEPCs and CECs observed in both groups of patients suggests an inadequate process of endothelial regeneration. Among analyzed factors inflammation and lipid abnormalities may have significant contribution in endothelial pathology in hypertension.
[Display omitted]</description><identifier>ISSN: 1537-1891</identifier><identifier>EISSN: 1879-3649</identifier><identifier>DOI: 10.1016/j.vph.2018.12.005</identifier><identifier>PMID: 30590133</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abnormalities ; Cells (biology) ; Cholesterol ; Circulating endothelial cells ; Circulating endothelial progenitor cells ; Endothelial cells ; Endothelial dysfunction ; Enzyme-linked immunosorbent assay ; Flow cytometry ; Hypertension ; Lipids ; Low density lipoprotein ; Mild hypertension ; Patients ; Progenitor cells ; Regeneration ; Resistant hypertension ; Stem cells ; Thrombomodulin ; Triglycerides</subject><ispartof>Vascular pharmacology, 2019-02, Vol.113, p.77-85</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Feb 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-d7e9b12c4da6a77bfa0a45f89e4f390bb25fea6d94c77534671d88fc43df42c33</citedby><cites>FETCH-LOGICAL-c381t-d7e9b12c4da6a77bfa0a45f89e4f390bb25fea6d94c77534671d88fc43df42c33</cites><orcidid>0000-0002-6282-3251</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1537189118302945$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30590133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Budzyń, Magdalena</creatorcontrib><creatorcontrib>Gryszczyńska, Bogna</creatorcontrib><creatorcontrib>Boruczkowski, Maciej</creatorcontrib><creatorcontrib>Kaczmarek, Mariusz</creatorcontrib><creatorcontrib>Begier-Krasińska, Beata</creatorcontrib><creatorcontrib>Osińska, Angelika</creatorcontrib><creatorcontrib>Bukowska, Alicja</creatorcontrib><creatorcontrib>Iskra, Maria</creatorcontrib><creatorcontrib>Kasprzak, Magdalena Paulina</creatorcontrib><title>The endothelial status reflected by circulating endothelial cells, circulating endothelial progenitor cells and soluble thrombomodulin in patients with mild and resistant hypertension</title><title>Vascular pharmacology</title><addtitle>Vascul Pharmacol</addtitle><description>The aim of the present study was to evaluate endothelial status by measuring the concentration of novel markers of endothelial dysfunction (ED): a number of circulating endothelial cells (CECs), circulating endothelial progenitor cells (CEPCs) and their ratio (CEPCs/CECs) as well as a traditional parameter - soluble thrombomodulin (sTM) in patients with resistant (RH) and mild hypertension (MH).
Thirty patients with MH and thirty subjects with RH were involved in the study. The control group included thirty-three age and sex-matched normotensive volunteers. We used multicolor flow cytometry for CECs and CEPCs analysis and the commercial human sTM ELISA kit to measure plasma sTM concentration.
An elevated CECs number and a decreased CEPCs/CECs ratio was found in MH as well as in RH patients in comparison with normotensive volunteers. CECs correlated positively with an increased triglycerides in MH patients and an elevated LDL-cholesterol and hsCRP in RH group. Positive correlation between CEPCs and LDL-cholesterol level was observed in both types of hypertension.
The results of the present study suggest that an endothelial alteration accompanies hypertension. The number of CECs reflecting the extent of endothelial damage does not appear to be related to the severity of disease. The drastically decreased ratio between CEPCs and CECs observed in both groups of patients suggests an inadequate process of endothelial regeneration. Among analyzed factors inflammation and lipid abnormalities may have significant contribution in endothelial pathology in hypertension.
[Display omitted]</description><subject>Abnormalities</subject><subject>Cells (biology)</subject><subject>Cholesterol</subject><subject>Circulating endothelial cells</subject><subject>Circulating endothelial progenitor cells</subject><subject>Endothelial cells</subject><subject>Endothelial dysfunction</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Flow cytometry</subject><subject>Hypertension</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Mild hypertension</subject><subject>Patients</subject><subject>Progenitor cells</subject><subject>Regeneration</subject><subject>Resistant hypertension</subject><subject>Stem cells</subject><subject>Thrombomodulin</subject><subject>Triglycerides</subject><issn>1537-1891</issn><issn>1879-3649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kc-K1TAUh4Moznj1AdxIwI2Lac2ftmlxJYOjwoCbcR3S5HSaS5rUJJ3hPpmvZ653FBQUAgnkOz_OOR9CLympKaHd2319t841I7SvKasJaR-hc9qLoeJdMzwu75aLivYDPUPPUtqTAvbd8BSdcdIOhHJ-jr7fzIDBm5BncFY5nLLKW8IRJgc6g8HjAWsb9eZUtv72D1aDc-nin99rDLfgbQ7xRGLlDU7BbaMDnOcYljEswWzOelzOWhLA54TvbZ7xYp35WRAh2dKUz3g-rBAz-GSDf46eTMolePFw79DXqw83l5-q6y8fP1--v64072mujIBhpEw3RnVKiHFSRDXt1A_QTHwg48jaCVRnhkYL0fKmE9T0_aQbbqaGac536M0ptwzzbYOU5WLTcRrlIWxJMtpRQcjA-4K-_gvdhy360p1kjJKeiaYI2SF6onQMKZU1yzXaRcWDpEQercq9LFbl0aqkTBarpebVQ_I2LmB-V_zSWIB3JwDKKu4sRJl02aUGY2OxKE2w_4n_ATOkuJU</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Budzyń, Magdalena</creator><creator>Gryszczyńska, Bogna</creator><creator>Boruczkowski, Maciej</creator><creator>Kaczmarek, Mariusz</creator><creator>Begier-Krasińska, Beata</creator><creator>Osińska, Angelika</creator><creator>Bukowska, Alicja</creator><creator>Iskra, Maria</creator><creator>Kasprzak, Magdalena Paulina</creator><general>Elsevier Inc</general><general>Elsevier Science Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6282-3251</orcidid></search><sort><creationdate>201902</creationdate><title>The endothelial status reflected by circulating endothelial cells, circulating endothelial progenitor cells and soluble thrombomodulin in patients with mild and resistant hypertension</title><author>Budzyń, Magdalena ; 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Thirty patients with MH and thirty subjects with RH were involved in the study. The control group included thirty-three age and sex-matched normotensive volunteers. We used multicolor flow cytometry for CECs and CEPCs analysis and the commercial human sTM ELISA kit to measure plasma sTM concentration.
An elevated CECs number and a decreased CEPCs/CECs ratio was found in MH as well as in RH patients in comparison with normotensive volunteers. CECs correlated positively with an increased triglycerides in MH patients and an elevated LDL-cholesterol and hsCRP in RH group. Positive correlation between CEPCs and LDL-cholesterol level was observed in both types of hypertension.
The results of the present study suggest that an endothelial alteration accompanies hypertension. The number of CECs reflecting the extent of endothelial damage does not appear to be related to the severity of disease. The drastically decreased ratio between CEPCs and CECs observed in both groups of patients suggests an inadequate process of endothelial regeneration. Among analyzed factors inflammation and lipid abnormalities may have significant contribution in endothelial pathology in hypertension.
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| ispartof | Vascular pharmacology, 2019-02, Vol.113, p.77-85 |
| issn | 1537-1891 1879-3649 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Abnormalities Cells (biology) Cholesterol Circulating endothelial cells Circulating endothelial progenitor cells Endothelial cells Endothelial dysfunction Enzyme-linked immunosorbent assay Flow cytometry Hypertension Lipids Low density lipoprotein Mild hypertension Patients Progenitor cells Regeneration Resistant hypertension Stem cells Thrombomodulin Triglycerides |
| title | The endothelial status reflected by circulating endothelial cells, circulating endothelial progenitor cells and soluble thrombomodulin in patients with mild and resistant hypertension |
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