Bone Marrow-Derived Macrophages Enhance Vessel Stability in Modular Engineered Tissues

Macrophages play a central role in the host response to tissue engineered constructs and their resultant vascularization. With a diversity of phenotypes, it is important to control the macrophage response to maximize vessel formation. We use a bottom-up tissue fabrication system (“modular tissue eng...

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Veröffentlicht in:	Tissue engineering. Part A 2019-06, Vol.25 (11-12), p.911-923
Hauptverfasser:	West, Michael E.D., Sefton, Elana J.B., Sefton, Michael V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adipose Tissue - cytology Adipose Tissue - metabolism Animals Bisphosphonates Blood vessels Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Clodronic acid Clodronic Acid - pharmacology Collagen Endothelial cells Explants Genotype & phenotype Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans Inflammation Interleukin 4 Macrophages Macrophages - cytology Macrophages - metabolism Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Mice Mice, SCID Neovascularization, Physiologic Original Articles Phenotypes Smooth muscle Stromal cells Tissue Engineering Umbilical vein Vascularization γ-Interferon
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