Hypoxia-induced upregulation of angiogenic factors in immortalized human periodontal ligament fibroblasts

Hypoxia induces complex cellular responses that are mediated by a key transcription factor, hypoxia-inducible factor-1 (HIF-1). HIF-1 promotes production of cytokines and angiogenic factors and contributes to recovery of injured tissues. In the present study, expressions of angiogenin (ANG) and vasc...

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Veröffentlicht in:	Journal of Oral Science 2018, Vol.60(4), pp.519-525
Hauptverfasser:	Kifune, Takashi, Ito, Hisanori, Ishiyama, Misa, Iwasa, Satoko, Takei, Hiroki, Hasegawa, Tomokazu, Asano, Masatake, Shirakawa, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenin Blotting, Western Cell Line Cells, Cultured Cytokines - metabolism Dentistry Fibroblasts - metabolism Fluorescent Antibody Technique HIF-1 Humans Hypoxia Hypoxia-Inducible Factor 1 - metabolism Periodontal Ligament - cytology periodontal ligament fibroblasts Real-Time Polymerase Chain Reaction Ribonuclease, Pancreatic - metabolism RNA, Messenger - metabolism Up-Regulation vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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