Functional implications of single nucleotide polymorphisms rs662 and rs854860 on the antioxidative activity of paraoxonase1 (PON1) in patients with rheumatoid arthritis

Background Atherosclerosis leading to cardiovascular disease (CVD) is the main cause of mortality and morbidity in patients with rheumatoid arthritis (RA). Paraoxonase1 (PON1) is the best understood member of plasma paraoxonases with anti-atherogenic properties. Patients and methods Spanish RA ( n ...

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Veröffentlicht in:	Clinical rheumatology 2019-05, Vol.38 (5), p.1329-1337
Hauptverfasser:	Mucientes, Arkaitz, Fernández-Gutiérrez, Benjamín, Herranz, Eva, Rodriguez-Rodriguez, Luis, Varadé, Jezabel, Urcelay, Elena, Lamas, José Ramón
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino acid sequence Antioxidants - metabolism Arteriosclerosis Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - genetics Aryldialkylphosphatase - genetics Aryldialkylphosphatase - metabolism Arylesterase Cardiovascular diseases Cardiovascular Diseases - enzymology Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Case-Control Studies Enzymatic activity Enzyme-linked immunosorbent assay Enzymes Female Genotype Genotyping Humans Male Medicine Medicine & Public Health Middle Aged Morbidity Original Article Paraoxonase Polymorphism, Single Nucleotide Rheumatoid arthritis Rheumatology Single-nucleotide polymorphism Spain
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