Genomic and tumor biological aspects of the anticancer nicotinamide phosphoribosyltransferase inhibitor FK866 in resistant human colorectal cancer cells

Cancer cells' resistance to drugs remains an important problem affecting cancer treatment strategies. We previously studied the nicotinamide phosphoribosyltransferase (NAMPT) inhibitor FK866's resistance mechanisms in the human colorectal cancer HCT116 cells. We established an acquired FK8...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2019-12, Vol.111 (6), p.1889-1895
Hauptverfasser:	Ogino, Yoko, Sato, Akira, Uchiumi, Fumiaki, Tanuma, Sei-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Acrylamides - administration & dosage Acrylamides - pharmacology Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Cisplatin - administration & dosage Cisplatin - pharmacology Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - radiotherapy Cytokines - antagonists & inhibitors DNA Damage - drug effects DNA Damage - genetics DNA Damage - radiation effects Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzyme Inhibitors - pharmacology FK866 Fluorouracil - administration & dosage Fluorouracil - pharmacology Gamma Rays Gene Expression Regulation, Neoplastic - drug effects Genomics HCT116 Cells Humans NAD+ biosynthetic pathway NAMPT NAMPT inhibitor Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors Piperidines - administration & dosage Piperidines - pharmacology Whole Exome Sequencing
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