Bicarbonate Supplement Restores Urinary Klotho Excretion in Chronic Kidney Disease: A Pilot Study
We tested the hypothesis that correcting acidosis may improve urinary Klotho excretion and serum α-Klotho. This is a prospective, interventional, nonrandomized, open-label trial study. In this study setting, metabolic acidosis is commonly observed during chronic kidney disease (CKD). We reported a p...
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| Veröffentlicht in: | J Ren Nutr 2019-07, Vol.29 (4), p.285-288 |
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| creator | Hage, Valerie Villain, Cedric Pelletier, Solenne Laville, Maurice Drai, Jocelyne Fouque, Denis |
| description | We tested the hypothesis that correcting acidosis may improve urinary Klotho excretion and serum α-Klotho.
This is a prospective, interventional, nonrandomized, open-label trial study. In this study setting, metabolic acidosis is commonly observed during chronic kidney disease (CKD). We reported a positive relationship between serum bicarbonate (Sbicar) and serum α-Klotho in these patients.
The study involved 20 patients with a known kidney disease referred for renal checkup. Inclusion criteria were age ≥ 18 years, CKD stage 3-5 non dialysis, Sbicar < 22 mmol/L, and not receiving bicarbonate supplementation.
Patients were then prescribed 1 g of oral sodium bicarbonate 3 times per day for 4 weeks.
Patients were evaluated at two and 4 weeks by blood and urine measurements.
Mean serum Klotho was 615 ± 287 pg/mL, and mean serum Sbicar was 19.3 ± 1.7 mmol/L at baseline. Sbicar increased from baseline at two (23.9 ± 2.9 mmol/L, P |
| doi_str_mv | 10.1053/j.jrn.2018.11.001 |
| format | Article |
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This is a prospective, interventional, nonrandomized, open-label trial study. In this study setting, metabolic acidosis is commonly observed during chronic kidney disease (CKD). We reported a positive relationship between serum bicarbonate (Sbicar) and serum α-Klotho in these patients.
The study involved 20 patients with a known kidney disease referred for renal checkup. Inclusion criteria were age ≥ 18 years, CKD stage 3-5 non dialysis, Sbicar < 22 mmol/L, and not receiving bicarbonate supplementation.
Patients were then prescribed 1 g of oral sodium bicarbonate 3 times per day for 4 weeks.
Patients were evaluated at two and 4 weeks by blood and urine measurements.
Mean serum Klotho was 615 ± 287 pg/mL, and mean serum Sbicar was 19.3 ± 1.7 mmol/L at baseline. Sbicar increased from baseline at two (23.9 ± 2.9 mmol/L, P < .001) and 4 weeks (23.4 ± 1.9 mmol/L, P < .001). There was no change in serum Klotho at two (630 ± 333 mmol/L) and 4 weeks (632 ± 285 mmol/L). By contrast, urine Klotho/creatinine ratio, which was very low at baseline (34.6 ± 31.6 pg/mmoL), increased by 320% at two weeks (P < .005) and by 280% at 4 weeks (P < .01).
Correcting acidosis by oral administration of sodium bicarbonate rapidly increases the urine excretion of soluble α-Klotho in CKD patients. However, a 4-week bicarbonate treatment was not able to increase serum α-Klotho. A longer study may confirm this pilot observation and increase serum Klotho, which has been shown to exert a protective cardiovascular effect during CKD.</description><identifier>ISSN: 1051-2276</identifier><identifier>EISSN: 1532-8503</identifier><identifier>DOI: 10.1053/j.jrn.2018.11.001</identifier><identifier>PMID: 30581063</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Life Sciences</subject><ispartof>J Ren Nutr, 2019-07, Vol.29 (4), p.285-288</ispartof><rights>2018 National Kidney Foundation, Inc.</rights><rights>Copyright © 2018 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-c0834b7b8b6bd8cf96cec5800eb7c1b088f8b1117d606a1061ff601d1e44d85d3</citedby><cites>FETCH-LOGICAL-c430t-c0834b7b8b6bd8cf96cec5800eb7c1b088f8b1117d606a1061ff601d1e44d85d3</cites><orcidid>0000-0002-9707-7199 ; 0000-0003-2253-1833</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/j.jrn.2018.11.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30581063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02195243$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Hage, Valerie</creatorcontrib><creatorcontrib>Villain, Cedric</creatorcontrib><creatorcontrib>Pelletier, Solenne</creatorcontrib><creatorcontrib>Laville, Maurice</creatorcontrib><creatorcontrib>Drai, Jocelyne</creatorcontrib><creatorcontrib>Fouque, Denis</creatorcontrib><title>Bicarbonate Supplement Restores Urinary Klotho Excretion in Chronic Kidney Disease: A Pilot Study</title><title>J Ren Nutr</title><addtitle>J Ren Nutr</addtitle><description>We tested the hypothesis that correcting acidosis may improve urinary Klotho excretion and serum α-Klotho.
This is a prospective, interventional, nonrandomized, open-label trial study. In this study setting, metabolic acidosis is commonly observed during chronic kidney disease (CKD). We reported a positive relationship between serum bicarbonate (Sbicar) and serum α-Klotho in these patients.
The study involved 20 patients with a known kidney disease referred for renal checkup. Inclusion criteria were age ≥ 18 years, CKD stage 3-5 non dialysis, Sbicar < 22 mmol/L, and not receiving bicarbonate supplementation.
Patients were then prescribed 1 g of oral sodium bicarbonate 3 times per day for 4 weeks.
Patients were evaluated at two and 4 weeks by blood and urine measurements.
Mean serum Klotho was 615 ± 287 pg/mL, and mean serum Sbicar was 19.3 ± 1.7 mmol/L at baseline. Sbicar increased from baseline at two (23.9 ± 2.9 mmol/L, P < .001) and 4 weeks (23.4 ± 1.9 mmol/L, P < .001). There was no change in serum Klotho at two (630 ± 333 mmol/L) and 4 weeks (632 ± 285 mmol/L). By contrast, urine Klotho/creatinine ratio, which was very low at baseline (34.6 ± 31.6 pg/mmoL), increased by 320% at two weeks (P < .005) and by 280% at 4 weeks (P < .01).
Correcting acidosis by oral administration of sodium bicarbonate rapidly increases the urine excretion of soluble α-Klotho in CKD patients. However, a 4-week bicarbonate treatment was not able to increase serum α-Klotho. A longer study may confirm this pilot observation and increase serum Klotho, which has been shown to exert a protective cardiovascular effect during CKD.</description><subject>Life Sciences</subject><issn>1051-2276</issn><issn>1532-8503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kU9vEzEQxVcIREvhA3BBPsJhl5n1euPCKYRCUSOBKD1b_jOrONrYwd6tyLfHUUqPnMYa_ebp-b2qeo3QIAj-fttsU2haQNkgNgD4pDpHwdtaCuBPyxsE1m276M-qFzlvC4BCts-rMw5CIvT8vNKfvNXJxKAnYrfzfj_SjsLEflKeYqLM7pIPOh3YzRinTWRXf2yiycfAfGCrTYrBW3bjXaAD--wz6Uwf2JL98AVnt9PsDi-rZ4MeM716mBfV3ZerX6vrev3967fVcl3bjsNUW5C8MwsjTW-ctMNlb8kKCUBmYdGAlIM0iLhwPfS6mMdh6AEdUtc5KRy_qN6ddDd6VPvkd8W1itqr6-VaHXfQ4qVoO36PhX17Yvcp_p7LV9XOZ0vjqAPFOasWi7TgxVFB8YTaFHNONDxqI6hjC2qrSgvq2IJCVCXkcvPmQX42O3KPF_9iL8DHE0AlkHtPSWXrKVhyPpGdlIv-P_J_AV2eluo</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Hage, Valerie</creator><creator>Villain, Cedric</creator><creator>Pelletier, Solenne</creator><creator>Laville, Maurice</creator><creator>Drai, Jocelyne</creator><creator>Fouque, Denis</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-9707-7199</orcidid><orcidid>https://orcid.org/0000-0003-2253-1833</orcidid></search><sort><creationdate>20190701</creationdate><title>Bicarbonate Supplement Restores Urinary Klotho Excretion in Chronic Kidney Disease: A Pilot Study</title><author>Hage, Valerie ; Villain, Cedric ; Pelletier, Solenne ; Laville, Maurice ; Drai, Jocelyne ; Fouque, Denis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-c0834b7b8b6bd8cf96cec5800eb7c1b088f8b1117d606a1061ff601d1e44d85d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hage, Valerie</creatorcontrib><creatorcontrib>Villain, Cedric</creatorcontrib><creatorcontrib>Pelletier, Solenne</creatorcontrib><creatorcontrib>Laville, Maurice</creatorcontrib><creatorcontrib>Drai, Jocelyne</creatorcontrib><creatorcontrib>Fouque, Denis</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>J Ren Nutr</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hage, Valerie</au><au>Villain, Cedric</au><au>Pelletier, Solenne</au><au>Laville, Maurice</au><au>Drai, Jocelyne</au><au>Fouque, Denis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bicarbonate Supplement Restores Urinary Klotho Excretion in Chronic Kidney Disease: A Pilot Study</atitle><jtitle>J Ren Nutr</jtitle><addtitle>J Ren Nutr</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>29</volume><issue>4</issue><spage>285</spage><epage>288</epage><pages>285-288</pages><issn>1051-2276</issn><eissn>1532-8503</eissn><abstract>We tested the hypothesis that correcting acidosis may improve urinary Klotho excretion and serum α-Klotho.
This is a prospective, interventional, nonrandomized, open-label trial study. In this study setting, metabolic acidosis is commonly observed during chronic kidney disease (CKD). We reported a positive relationship between serum bicarbonate (Sbicar) and serum α-Klotho in these patients.
The study involved 20 patients with a known kidney disease referred for renal checkup. Inclusion criteria were age ≥ 18 years, CKD stage 3-5 non dialysis, Sbicar < 22 mmol/L, and not receiving bicarbonate supplementation.
Patients were then prescribed 1 g of oral sodium bicarbonate 3 times per day for 4 weeks.
Patients were evaluated at two and 4 weeks by blood and urine measurements.
Mean serum Klotho was 615 ± 287 pg/mL, and mean serum Sbicar was 19.3 ± 1.7 mmol/L at baseline. Sbicar increased from baseline at two (23.9 ± 2.9 mmol/L, P < .001) and 4 weeks (23.4 ± 1.9 mmol/L, P < .001). There was no change in serum Klotho at two (630 ± 333 mmol/L) and 4 weeks (632 ± 285 mmol/L). By contrast, urine Klotho/creatinine ratio, which was very low at baseline (34.6 ± 31.6 pg/mmoL), increased by 320% at two weeks (P < .005) and by 280% at 4 weeks (P < .01).
Correcting acidosis by oral administration of sodium bicarbonate rapidly increases the urine excretion of soluble α-Klotho in CKD patients. However, a 4-week bicarbonate treatment was not able to increase serum α-Klotho. A longer study may confirm this pilot observation and increase serum Klotho, which has been shown to exert a protective cardiovascular effect during CKD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30581063</pmid><doi>10.1053/j.jrn.2018.11.001</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9707-7199</orcidid><orcidid>https://orcid.org/0000-0003-2253-1833</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Bicarbonate Supplement Restores Urinary Klotho Excretion in Chronic Kidney Disease: A Pilot Study |
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