Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy
Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). A total of 1296 subjects (61 ± 9, 56.9% male) who underw...
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| creator | Won, Ki-Bum Lee, Sang-Eun Lee, Byoung Kwon Park, Hyung-Bok Heo, Ran Rizvi, Asim Lin, Fay Y. Kumar, Amit Hadamitzky, Martin Kim, Yong-Jin Sung, Ji Min Conte, Edoardo Andreini, Daniele Pontone, Gianluca Budoff, Matthew J. Gottlieb, Ilan Chun, Eun Ju Cademartiri, Filippo Maffei, Erica Marques, Hugo Leipsic, Jonathon A. Shin, Sanghoon Choi, Jung Hyun Virmani, Renu Samady, Habib Chinnaiyan, Kavitha Raff, Gilbert L. Stone, Peter H. Berman, Daniel S. Narula, Jagat Shaw, Leslee J. Bax, Jeroen J. Min, James K. Chang, Hyuk-Jae |
| description | Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA).
A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6–4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM).
During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p |
| doi_str_mv | 10.1016/j.jcct.2018.12.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2160152989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1934592518301813</els_id><sourcerecordid>2160152989</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-c947839ed74d6f498f84015cfe8683618c7d155b53785a7ca2a61565864c5d8f3</originalsourceid><addsrcrecordid>eNp9kUFv1DAUhCMEoqXwBzggH8shwXbixEFcoi1dVlrEqioSN8vrvGS9SuLUdirlxyPV0W7LjZMta9438zxR9JHghGCSfzkmR6V8QjHhCaEJxvRVdEl4kcc8J39eh3uZZjErKbuI3jl3xJgVBPO30UWKGcdlSS-jv1sztNpPtR5kh6Rz4FwPg0emQcpYM0g7o7GTDxOgR9NNPSB1kEMLyEInPdTIG9R2s4JeK-S89JNDk9NDixxYHZgvFGX6cTpN9Ka1cjzMKJD0-f4VVWhX3VU3m_VPdL2z4Tlk0WZYolT-AHfGqQ6s8cFo11VLohvwYPvNEKD7Ga2eDe6DwXqBBmX1zwFtetmGZJ-Rm_Yu7Dy_j940snPw4XxeRb9vv9-vfsTbX-vNqtrGKqPUx6rMCp6WUBdZnTdZyRueYcJUAzznaU64KmrC2J6lBWeyUJLKnLCc8TxTrOZNehVdn7ijNSG386LXTkHXyQHM5AQleeDRkpdBSk9SZY1zFhoxWt2H_xMEi6V2cRRL7WKpXRAqQu1h6NOZP-17qF9GnnsOgm8nAYQtHzVY4ZSGQUGtLQRYbfT_-E_sfsVL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2160152989</pqid></control><display><type>article</type><title>Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy</title><source>Elsevier ScienceDirect Journals</source><creator>Won, Ki-Bum ; Lee, Sang-Eun ; Lee, Byoung Kwon ; Park, Hyung-Bok ; Heo, Ran ; Rizvi, Asim ; Lin, Fay Y. ; Kumar, Amit ; Hadamitzky, Martin ; Kim, Yong-Jin ; Sung, Ji Min ; Conte, Edoardo ; Andreini, Daniele ; Pontone, Gianluca ; Budoff, Matthew J. ; Gottlieb, Ilan ; Chun, Eun Ju ; Cademartiri, Filippo ; Maffei, Erica ; Marques, Hugo ; Leipsic, Jonathon A. ; Shin, Sanghoon ; Choi, Jung Hyun ; Virmani, Renu ; Samady, Habib ; Chinnaiyan, Kavitha ; Raff, Gilbert L. ; Stone, Peter H. ; Berman, Daniel S. ; Narula, Jagat ; Shaw, Leslee J. ; Bax, Jeroen J. ; Min, James K. ; Chang, Hyuk-Jae</creator><creatorcontrib>Won, Ki-Bum ; Lee, Sang-Eun ; Lee, Byoung Kwon ; Park, Hyung-Bok ; Heo, Ran ; Rizvi, Asim ; Lin, Fay Y. ; Kumar, Amit ; Hadamitzky, Martin ; Kim, Yong-Jin ; Sung, Ji Min ; Conte, Edoardo ; Andreini, Daniele ; Pontone, Gianluca ; Budoff, Matthew J. ; Gottlieb, Ilan ; Chun, Eun Ju ; Cademartiri, Filippo ; Maffei, Erica ; Marques, Hugo ; Leipsic, Jonathon A. ; Shin, Sanghoon ; Choi, Jung Hyun ; Virmani, Renu ; Samady, Habib ; Chinnaiyan, Kavitha ; Raff, Gilbert L. ; Stone, Peter H. ; Berman, Daniel S. ; Narula, Jagat ; Shaw, Leslee J. ; Bax, Jeroen J. ; Min, James K. ; Chang, Hyuk-Jae</creatorcontrib><description>Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA).
A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6–4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM).
During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010).
DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors.
ClinicalTrials.govNCT02803411.</description><identifier>ISSN: 1934-5925</identifier><identifier>EISSN: 1876-861X</identifier><identifier>DOI: 10.1016/j.jcct.2018.12.002</identifier><identifier>PMID: 30580992</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Coronary atherosclerosis ; Coronary computed tomography angiography ; Pre-diabetes</subject><ispartof>Journal of cardiovascular computed tomography, 2019-03, Vol.13 (2), p.142-147</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-c947839ed74d6f498f84015cfe8683618c7d155b53785a7ca2a61565864c5d8f3</citedby><cites>FETCH-LOGICAL-c422t-c947839ed74d6f498f84015cfe8683618c7d155b53785a7ca2a61565864c5d8f3</cites><orcidid>0000-0002-9616-1946 ; 0000-0001-5502-9933 ; 0000-0003-0402-5769 ; 0000-0002-0579-3279 ; 0000-0002-1041-8035</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcct.2018.12.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30580992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Won, Ki-Bum</creatorcontrib><creatorcontrib>Lee, Sang-Eun</creatorcontrib><creatorcontrib>Lee, Byoung Kwon</creatorcontrib><creatorcontrib>Park, Hyung-Bok</creatorcontrib><creatorcontrib>Heo, Ran</creatorcontrib><creatorcontrib>Rizvi, Asim</creatorcontrib><creatorcontrib>Lin, Fay Y.</creatorcontrib><creatorcontrib>Kumar, Amit</creatorcontrib><creatorcontrib>Hadamitzky, Martin</creatorcontrib><creatorcontrib>Kim, Yong-Jin</creatorcontrib><creatorcontrib>Sung, Ji Min</creatorcontrib><creatorcontrib>Conte, Edoardo</creatorcontrib><creatorcontrib>Andreini, Daniele</creatorcontrib><creatorcontrib>Pontone, Gianluca</creatorcontrib><creatorcontrib>Budoff, Matthew J.</creatorcontrib><creatorcontrib>Gottlieb, Ilan</creatorcontrib><creatorcontrib>Chun, Eun Ju</creatorcontrib><creatorcontrib>Cademartiri, Filippo</creatorcontrib><creatorcontrib>Maffei, Erica</creatorcontrib><creatorcontrib>Marques, Hugo</creatorcontrib><creatorcontrib>Leipsic, Jonathon A.</creatorcontrib><creatorcontrib>Shin, Sanghoon</creatorcontrib><creatorcontrib>Choi, Jung Hyun</creatorcontrib><creatorcontrib>Virmani, Renu</creatorcontrib><creatorcontrib>Samady, Habib</creatorcontrib><creatorcontrib>Chinnaiyan, Kavitha</creatorcontrib><creatorcontrib>Raff, Gilbert L.</creatorcontrib><creatorcontrib>Stone, Peter H.</creatorcontrib><creatorcontrib>Berman, Daniel S.</creatorcontrib><creatorcontrib>Narula, Jagat</creatorcontrib><creatorcontrib>Shaw, Leslee J.</creatorcontrib><creatorcontrib>Bax, Jeroen J.</creatorcontrib><creatorcontrib>Min, James K.</creatorcontrib><creatorcontrib>Chang, Hyuk-Jae</creatorcontrib><title>Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy</title><title>Journal of cardiovascular computed tomography</title><addtitle>J Cardiovasc Comput Tomogr</addtitle><description>Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA).
A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6–4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM).
During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010).
DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors.
ClinicalTrials.govNCT02803411.</description><subject>Coronary atherosclerosis</subject><subject>Coronary computed tomography angiography</subject><subject>Pre-diabetes</subject><issn>1934-5925</issn><issn>1876-861X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAUhCMEoqXwBzggH8shwXbixEFcoi1dVlrEqioSN8vrvGS9SuLUdirlxyPV0W7LjZMta9438zxR9JHghGCSfzkmR6V8QjHhCaEJxvRVdEl4kcc8J39eh3uZZjErKbuI3jl3xJgVBPO30UWKGcdlSS-jv1sztNpPtR5kh6Rz4FwPg0emQcpYM0g7o7GTDxOgR9NNPSB1kEMLyEInPdTIG9R2s4JeK-S89JNDk9NDixxYHZgvFGX6cTpN9Ka1cjzMKJD0-f4VVWhX3VU3m_VPdL2z4Tlk0WZYolT-AHfGqQ6s8cFo11VLohvwYPvNEKD7Ga2eDe6DwXqBBmX1zwFtetmGZJ-Rm_Yu7Dy_j940snPw4XxeRb9vv9-vfsTbX-vNqtrGKqPUx6rMCp6WUBdZnTdZyRueYcJUAzznaU64KmrC2J6lBWeyUJLKnLCc8TxTrOZNehVdn7ijNSG386LXTkHXyQHM5AQleeDRkpdBSk9SZY1zFhoxWt2H_xMEi6V2cRRL7WKpXRAqQu1h6NOZP-17qF9GnnsOgm8nAYQtHzVY4ZSGQUGtLQRYbfT_-E_sfsVL</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Won, Ki-Bum</creator><creator>Lee, Sang-Eun</creator><creator>Lee, Byoung Kwon</creator><creator>Park, Hyung-Bok</creator><creator>Heo, Ran</creator><creator>Rizvi, Asim</creator><creator>Lin, Fay Y.</creator><creator>Kumar, Amit</creator><creator>Hadamitzky, Martin</creator><creator>Kim, Yong-Jin</creator><creator>Sung, Ji Min</creator><creator>Conte, Edoardo</creator><creator>Andreini, Daniele</creator><creator>Pontone, Gianluca</creator><creator>Budoff, Matthew J.</creator><creator>Gottlieb, Ilan</creator><creator>Chun, Eun Ju</creator><creator>Cademartiri, Filippo</creator><creator>Maffei, Erica</creator><creator>Marques, Hugo</creator><creator>Leipsic, Jonathon A.</creator><creator>Shin, Sanghoon</creator><creator>Choi, Jung Hyun</creator><creator>Virmani, Renu</creator><creator>Samady, Habib</creator><creator>Chinnaiyan, Kavitha</creator><creator>Raff, Gilbert L.</creator><creator>Stone, Peter H.</creator><creator>Berman, Daniel S.</creator><creator>Narula, Jagat</creator><creator>Shaw, Leslee J.</creator><creator>Bax, Jeroen J.</creator><creator>Min, James K.</creator><creator>Chang, Hyuk-Jae</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9616-1946</orcidid><orcidid>https://orcid.org/0000-0001-5502-9933</orcidid><orcidid>https://orcid.org/0000-0003-0402-5769</orcidid><orcidid>https://orcid.org/0000-0002-0579-3279</orcidid><orcidid>https://orcid.org/0000-0002-1041-8035</orcidid></search><sort><creationdate>201903</creationdate><title>Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy</title><author>Won, Ki-Bum ; Lee, Sang-Eun ; Lee, Byoung Kwon ; Park, Hyung-Bok ; Heo, Ran ; Rizvi, Asim ; Lin, Fay Y. ; Kumar, Amit ; Hadamitzky, Martin ; Kim, Yong-Jin ; Sung, Ji Min ; Conte, Edoardo ; Andreini, Daniele ; Pontone, Gianluca ; Budoff, Matthew J. ; Gottlieb, Ilan ; Chun, Eun Ju ; Cademartiri, Filippo ; Maffei, Erica ; Marques, Hugo ; Leipsic, Jonathon A. ; Shin, Sanghoon ; Choi, Jung Hyun ; Virmani, Renu ; Samady, Habib ; Chinnaiyan, Kavitha ; Raff, Gilbert L. ; Stone, Peter H. ; Berman, Daniel S. ; Narula, Jagat ; Shaw, Leslee J. ; Bax, Jeroen J. ; Min, James K. ; Chang, Hyuk-Jae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-c947839ed74d6f498f84015cfe8683618c7d155b53785a7ca2a61565864c5d8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Coronary atherosclerosis</topic><topic>Coronary computed tomography angiography</topic><topic>Pre-diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Won, Ki-Bum</creatorcontrib><creatorcontrib>Lee, Sang-Eun</creatorcontrib><creatorcontrib>Lee, Byoung Kwon</creatorcontrib><creatorcontrib>Park, Hyung-Bok</creatorcontrib><creatorcontrib>Heo, Ran</creatorcontrib><creatorcontrib>Rizvi, Asim</creatorcontrib><creatorcontrib>Lin, Fay Y.</creatorcontrib><creatorcontrib>Kumar, Amit</creatorcontrib><creatorcontrib>Hadamitzky, Martin</creatorcontrib><creatorcontrib>Kim, Yong-Jin</creatorcontrib><creatorcontrib>Sung, Ji Min</creatorcontrib><creatorcontrib>Conte, Edoardo</creatorcontrib><creatorcontrib>Andreini, Daniele</creatorcontrib><creatorcontrib>Pontone, Gianluca</creatorcontrib><creatorcontrib>Budoff, Matthew J.</creatorcontrib><creatorcontrib>Gottlieb, Ilan</creatorcontrib><creatorcontrib>Chun, Eun Ju</creatorcontrib><creatorcontrib>Cademartiri, Filippo</creatorcontrib><creatorcontrib>Maffei, Erica</creatorcontrib><creatorcontrib>Marques, Hugo</creatorcontrib><creatorcontrib>Leipsic, Jonathon A.</creatorcontrib><creatorcontrib>Shin, Sanghoon</creatorcontrib><creatorcontrib>Choi, Jung Hyun</creatorcontrib><creatorcontrib>Virmani, Renu</creatorcontrib><creatorcontrib>Samady, Habib</creatorcontrib><creatorcontrib>Chinnaiyan, Kavitha</creatorcontrib><creatorcontrib>Raff, Gilbert L.</creatorcontrib><creatorcontrib>Stone, Peter H.</creatorcontrib><creatorcontrib>Berman, Daniel S.</creatorcontrib><creatorcontrib>Narula, Jagat</creatorcontrib><creatorcontrib>Shaw, Leslee J.</creatorcontrib><creatorcontrib>Bax, Jeroen J.</creatorcontrib><creatorcontrib>Min, James K.</creatorcontrib><creatorcontrib>Chang, Hyuk-Jae</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular computed tomography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Won, Ki-Bum</au><au>Lee, Sang-Eun</au><au>Lee, Byoung Kwon</au><au>Park, Hyung-Bok</au><au>Heo, Ran</au><au>Rizvi, Asim</au><au>Lin, Fay Y.</au><au>Kumar, Amit</au><au>Hadamitzky, Martin</au><au>Kim, Yong-Jin</au><au>Sung, Ji Min</au><au>Conte, Edoardo</au><au>Andreini, Daniele</au><au>Pontone, Gianluca</au><au>Budoff, Matthew J.</au><au>Gottlieb, Ilan</au><au>Chun, Eun Ju</au><au>Cademartiri, Filippo</au><au>Maffei, Erica</au><au>Marques, Hugo</au><au>Leipsic, Jonathon A.</au><au>Shin, Sanghoon</au><au>Choi, Jung Hyun</au><au>Virmani, Renu</au><au>Samady, Habib</au><au>Chinnaiyan, Kavitha</au><au>Raff, Gilbert L.</au><au>Stone, Peter H.</au><au>Berman, Daniel S.</au><au>Narula, Jagat</au><au>Shaw, Leslee J.</au><au>Bax, Jeroen J.</au><au>Min, James K.</au><au>Chang, Hyuk-Jae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy</atitle><jtitle>Journal of cardiovascular computed tomography</jtitle><addtitle>J Cardiovasc Comput Tomogr</addtitle><date>2019-03</date><risdate>2019</risdate><volume>13</volume><issue>2</issue><spage>142</spage><epage>147</epage><pages>142-147</pages><issn>1934-5925</issn><eissn>1876-861X</eissn><abstract>Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA).
A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6–4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM).
During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967–1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126–2.375; p = 0.010).
DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors.
ClinicalTrials.govNCT02803411.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30580992</pmid><doi>10.1016/j.jcct.2018.12.002</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9616-1946</orcidid><orcidid>https://orcid.org/0000-0001-5502-9933</orcidid><orcidid>https://orcid.org/0000-0003-0402-5769</orcidid><orcidid>https://orcid.org/0000-0002-0579-3279</orcidid><orcidid>https://orcid.org/0000-0002-1041-8035</orcidid></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Coronary atherosclerosis Coronary computed tomography angiography Pre-diabetes |
| title | Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy |
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