Effect of AR antagonist combined with PARP1 inhibitor on sporadic triple-negative breast cancer bearing AR expression and methylation-mediated BRCA1 dysfunction

•AR expression indicates a poor disease-free survival (DFS) of TNBC patients when 1% staining was used as the threshold.•BRCA1-negative TNBC patients show a poor DFS, and it is associated with the methylation status of its promoter.•BRCA1-/AR+ TNBC patients have shorter DFS than other TNBC patients...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-03, Vol.111, p.169-177
Hauptverfasser:	Sang, Meixiang, Meng, Lingjiao, Ma, Cuicui, Liu, Sihua, Sang, Meijie, Chang, Sheng, Liu, Fei, Lian, Yishui, Geng, Cuizhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptor BRCA1 Enzalutamide Olaparib Triple-negative breast cancer
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!