Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α

Fibrosis and stricture are major comorbidities in patients with eosinophilic esophagitis (EoE). Lysyl oxidase (LOX), a collagen cross-linking enzyme, has not been investigated in the context of EoE. We investigated regulation of epithelial LOX expression as a novel biomarker and functional effector...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2019-07, Vol.144 (1), p.171-182
Hauptverfasser:	Kasagi, Yuta, Dods, Kara, Wang, Joshua X., Chandramouleeswaran, Prasanna M., Benitez, Alain J., Gambanga, Fiona, Kluger, Jonathan, Ashorobi, Tokunbo, Gross, Jonathan, Tobias, John W., Klein-Szanto, Andres J., Spergel, Jonathan M., Cianferoni, Antonella, Falk, Gary W., Whelan, Kelly A., Nakagawa, Hiroshi, Muir, Amanda B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Autoimmune diseases Bioindicators Biomarkers Biomarkers - metabolism Cell culture Cells, Cultured Child Child, Preschool coculture Coculture Techniques Collagen Complications Constriction, Pathologic Cross-linking Cytokines Demographics Dysphagia Endoscopy Eosinophilic esophagitis Eosinophilic Esophagitis - diagnosis Eosinophilic Esophagitis - genetics Epithelial cells Epithelial Cells - physiology Esophageal diseases Esophagitis Esophagus Esophagus - pathology Female Fibroblasts Fibroblasts - physiology Fibrosis Flow cytometry Fluorescence Food Gastrointestinal diseases Gene expression Gene Ontology Humans Hypothesis testing Infant Inflammation Leukocytes (eosinophilic) Liquid oxygen Lysyl oxidase Male Middle Aged Organoids Positive feedback Protein-Lysine 6-Oxidase - genetics Protein-Lysine 6-Oxidase - metabolism Proteins Ribonucleic acid RNA Secretion Smooth muscle Stenosis Steroids Stricture TGF-β TNF-α Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Up-Regulation Young Adult
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