Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy

ABSTRACT Tubulointerstitial inflammation plays a critical role in the progression of diabetic nephropathy (DN), and nucleotide‐binding oligomerization domain‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasomes contribute to renal interstitial inflammation in DN. Decreased expression...

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Veröffentlicht in:	The FASEB journal 2019-03, Vol.33 (3), p.4571-4585
Hauptverfasser:	Chen, Kehong, Feng, Lei, Hu, Wei, Chen, Jia, Wang, Xiaoyue, Wang, Liming, He, Yani
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Cell Cycle Proteins - analysis Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Cells, Cultured Diabetes Mellitus, Type 2 - complications Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Female Glucose - pharmacology Humans IL-18 IL-1β Inflammasomes - physiology Kidney Tubules, Proximal - metabolism Kidney Tubules, Proximal - pathology Male Membrane Potential, Mitochondrial Membrane Transport Proteins - analysis Membrane Transport Proteins - genetics Membrane Transport Proteins - physiology Mice Mice, Inbred C57BL Microscopy, Confocal Middle Aged mitochondria Mitochondria - metabolism Mitochondria - pathology Mitophagy - physiology NLR Family, Pyrin Domain-Containing 3 Protein - analysis NLR Family, Pyrin Domain-Containing 3 Protein - physiology OPTN Reactive Oxygen Species - metabolism Recombinant Proteins - metabolism RNA, Messenger - biosynthesis tubulointerstitial inflammation
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