Dysregulated IL-1β-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine

BACKGROUND:Acute rheumatic fever (ARF) and rheumatic heart disease are autoimmune consequences of group A streptococcus infection and remain major causes of cardiovascular morbidity and mortality around the world. Improved treatment has been stymied by gaps in understanding key steps in the immunopa...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2018-12, Vol.138 (23), p.2648-2661
Hauptverfasser:	Kim, Man Lyang, Martin, William J, Minigo, Gabriela, Keeble, Joanne L, Garnham, Alexandra L, Pacini, Guido, Smyth, Gordon K, Speed, Terence P, Carapetis, Jonathan, Wicks, Ian P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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