LncRNA GAS5 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition in oral squamous cell carcinoma by regulating the miR-21/PTEN axis

Growth-arrest-specific transcript 5 (GAS5) functions as a tumor suppressor in a variety of cancers. GAS5 has been reported to be down-regulated in oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the mechanisms of how GAS5 acts as a tumor suppressor in OSCC. qRT-PCR, cel...

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Veröffentlicht in:	Experimental cell research 2019-01, Vol.374 (2), p.365-373
Hauptverfasser:	Zeng, Binghui, Li, Ye, Jiang, Fangfang, Wei, Changbo, Chen, Guanhui, Zhang, Wenliang, Zhao, Wei, Yu, Dongsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Down-Regulation - genetics Epithelial-Mesenchymal Transition - genetics GAS5 Gene Expression Regulation, Neoplastic - genetics Genes, Tumor Suppressor - physiology Humans LncRNA MicroRNAs - genetics miR-21 Mouth Neoplasms - genetics Mouth Neoplasms - pathology Proto-Oncogene Proteins c-akt - genetics PTEN PTEN Phosphohydrolase - genetics RNA, Long Noncoding - genetics Signal Transduction - genetics Up-Regulation - genetics
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