Outcomes of Pediatric Liver Transplantation: Deceased Donor Liver Transplantation vs Living Donor Liver Transplantation
The use of pediatric donor liver for pediatric liver transplantation (LT) remains controversial and few studies have focused on pediatric deceased donors. To address this issue, we decided to perform a retrospective research, trying to compare the clinical effects between deceased donor LTs (DDLTs)...
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| Veröffentlicht in: | Transplantation proceedings 2018-12, Vol.50 (10), p.3601-3605 |
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| creator | Zhang, R. Zhu, Z.-J. Sun, L.-Y. Wei, L. Qu, W. Zeng, Z.-G. Liu, Y. |
| description | The use of pediatric donor liver for pediatric liver transplantation (LT) remains controversial and few studies have focused on pediatric deceased donors. To address this issue, we decided to perform a retrospective research, trying to compare the clinical effects between deceased donor LTs (DDLTs) and living donor LTs (LDLTs).
A retrospective review of pediatric LTs using grafts from deceased donors and living donors from June 2013 to August 2016 was performed. The children were divided into a DDLT group and a LDLT group based on their donor styles. The incidence of early vascular complications (VC), biliary complications, and graft and patient survival rates were observed between the 2 groups.
There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs). The 1-year cumulative survival rates of grafts and recipients were 89.16% and 91.57% in DDLTs, and 95.47% and 95.52% in LDLTs, respectively (P > .05). The incidence of early VC was lower in LDLTs than that in DDLTs (3.7% vs 19.3%, P < .001). The incidence of HAT in children aged less than 1 year was significantly higher in the DDLT group (P < .001) and can be up to 31.82%. The incidence of biliary complications was similar in the 2 groups (8.4% vs 13.5%, P = .285).
Pediatric DDLTs have similar graft and patient survival rates with LDLT. The incidence of early VC was higher in DDLTs, and children aged less than 1 year are at a higher risk of developing HAT.
•Along with considerable development of organ donation after death of people in China, pediatric donation has become an important supplement to the graft pool, which has an important role in decreasing mortality among patients on the waiting list.•This study evaluated the efficacy of pediatric liver transplantation (LT) using deceased donor whole liver and living donor liver, and compares the outcomes.•There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs).•The 1-year cumulative survival rates of grafts and recipients were 89.16%, 91.57% in DDLT, and 95.47%, 95.52% in LDLT, respectively (P > .05). The ratio of early VC was lower in LDLTs than that in DDLTs (3.73% vs 19.28%, P < .001).•The incidence of HAT in children aged less than 1 year was significantly higher among the DDLT group (P < .001), and the ratio can be up to 31.82%.•Our study showed that pediatric DDLT have a similar graft and patient survival rates with LDLT. The inci |
| doi_str_mv | 10.1016/j.transproceed.2018.04.035 |
| format | Article |
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A retrospective review of pediatric LTs using grafts from deceased donors and living donors from June 2013 to August 2016 was performed. The children were divided into a DDLT group and a LDLT group based on their donor styles. The incidence of early vascular complications (VC), biliary complications, and graft and patient survival rates were observed between the 2 groups.
There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs). The 1-year cumulative survival rates of grafts and recipients were 89.16% and 91.57% in DDLTs, and 95.47% and 95.52% in LDLTs, respectively (P > .05). The incidence of early VC was lower in LDLTs than that in DDLTs (3.7% vs 19.3%, P < .001). The incidence of HAT in children aged less than 1 year was significantly higher in the DDLT group (P < .001) and can be up to 31.82%. The incidence of biliary complications was similar in the 2 groups (8.4% vs 13.5%, P = .285).
Pediatric DDLTs have similar graft and patient survival rates with LDLT. The incidence of early VC was higher in DDLTs, and children aged less than 1 year are at a higher risk of developing HAT.
•Along with considerable development of organ donation after death of people in China, pediatric donation has become an important supplement to the graft pool, which has an important role in decreasing mortality among patients on the waiting list.•This study evaluated the efficacy of pediatric liver transplantation (LT) using deceased donor whole liver and living donor liver, and compares the outcomes.•There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs).•The 1-year cumulative survival rates of grafts and recipients were 89.16%, 91.57% in DDLT, and 95.47%, 95.52% in LDLT, respectively (P > .05). The ratio of early VC was lower in LDLTs than that in DDLTs (3.73% vs 19.28%, P < .001).•The incidence of HAT in children aged less than 1 year was significantly higher among the DDLT group (P < .001), and the ratio can be up to 31.82%.•Our study showed that pediatric DDLT have a similar graft and patient survival rates with LDLT. The incidence of VC was higher in DDLT, and children aged less than 1 year are at higher risk of developing HAT.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2018.04.035</identifier><identifier>PMID: 30577244</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Child ; Female ; Graft Survival ; Humans ; Incidence ; Infant ; Liver Transplantation - methods ; Liver Transplantation - mortality ; Living Donors ; Male ; Middle Aged ; Postoperative Complications - epidemiology ; Retrospective Studies ; Survival Rate ; Tissue Donors - supply & distribution</subject><ispartof>Transplantation proceedings, 2018-12, Vol.50 (10), p.3601-3605</ispartof><rights>2018 The Authors</rights><rights>Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-cd6c07f78f71dc2a7930c1d3ef9b10d335921fd11db29313634ac04dd9e9d6993</citedby><cites>FETCH-LOGICAL-c432t-cd6c07f78f71dc2a7930c1d3ef9b10d335921fd11db29313634ac04dd9e9d6993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2018.04.035$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30577244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, R.</creatorcontrib><creatorcontrib>Zhu, Z.-J.</creatorcontrib><creatorcontrib>Sun, L.-Y.</creatorcontrib><creatorcontrib>Wei, L.</creatorcontrib><creatorcontrib>Qu, W.</creatorcontrib><creatorcontrib>Zeng, Z.-G.</creatorcontrib><creatorcontrib>Liu, Y.</creatorcontrib><title>Outcomes of Pediatric Liver Transplantation: Deceased Donor Liver Transplantation vs Living Donor Liver Transplantation</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>The use of pediatric donor liver for pediatric liver transplantation (LT) remains controversial and few studies have focused on pediatric deceased donors. To address this issue, we decided to perform a retrospective research, trying to compare the clinical effects between deceased donor LTs (DDLTs) and living donor LTs (LDLTs).
A retrospective review of pediatric LTs using grafts from deceased donors and living donors from June 2013 to August 2016 was performed. The children were divided into a DDLT group and a LDLT group based on their donor styles. The incidence of early vascular complications (VC), biliary complications, and graft and patient survival rates were observed between the 2 groups.
There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs). The 1-year cumulative survival rates of grafts and recipients were 89.16% and 91.57% in DDLTs, and 95.47% and 95.52% in LDLTs, respectively (P > .05). The incidence of early VC was lower in LDLTs than that in DDLTs (3.7% vs 19.3%, P < .001). The incidence of HAT in children aged less than 1 year was significantly higher in the DDLT group (P < .001) and can be up to 31.82%. The incidence of biliary complications was similar in the 2 groups (8.4% vs 13.5%, P = .285).
Pediatric DDLTs have similar graft and patient survival rates with LDLT. The incidence of early VC was higher in DDLTs, and children aged less than 1 year are at a higher risk of developing HAT.
•Along with considerable development of organ donation after death of people in China, pediatric donation has become an important supplement to the graft pool, which has an important role in decreasing mortality among patients on the waiting list.•This study evaluated the efficacy of pediatric liver transplantation (LT) using deceased donor whole liver and living donor liver, and compares the outcomes.•There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs).•The 1-year cumulative survival rates of grafts and recipients were 89.16%, 91.57% in DDLT, and 95.47%, 95.52% in LDLT, respectively (P > .05). The ratio of early VC was lower in LDLTs than that in DDLTs (3.73% vs 19.28%, P < .001).•The incidence of HAT in children aged less than 1 year was significantly higher among the DDLT group (P < .001), and the ratio can be up to 31.82%.•Our study showed that pediatric DDLT have a similar graft and patient survival rates with LDLT. The incidence of VC was higher in DDLT, and children aged less than 1 year are at higher risk of developing HAT.</description><subject>Adult</subject><subject>Child</subject><subject>Female</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Liver Transplantation - methods</subject><subject>Liver Transplantation - mortality</subject><subject>Living Donors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Complications - epidemiology</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tissue Donors - supply & distribution</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LAzEQhoMotlb_giyevOyar_1Ib9L6BYV6qOeQJrOS0t3UZFvx35u1FTyIeBrCPDPv5EHoiuCMYFLcrLLOqzZsvNMAJqOYVBnmGWb5ERqSqmQpLSg7RkOMOUkJ4_kAnYWwwvFNOTtFA4bzsqScD9H7fNtp10BIXJ08g7Gq81YnM7sDnyy-Ytaq7VRnXTtOpqBBBTDJ1LXO_04lu9A3bPv6F3WOTmq1DnBxqCP0cn-3mDyms_nD0-R2lmrOaJdqU2hc1mVVl8RoqkrBsCaGQS2WBBvGckFJbQgxSyoYYQXjSmNujABhCiHYCF3v90Zbb1sInWxs0LCOh4DbBklJLkSVC96j4z2qvQvBQy033jbKf0iCZS9eruRP8bIXLzGXUXwcvjzkbJdN7H2PfpuOwHQPQPztzoKXQVtodVTuQXfSOPufnE94AJ3c</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Zhang, R.</creator><creator>Zhu, Z.-J.</creator><creator>Sun, L.-Y.</creator><creator>Wei, L.</creator><creator>Qu, W.</creator><creator>Zeng, Z.-G.</creator><creator>Liu, Y.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>Outcomes of Pediatric Liver Transplantation: Deceased Donor Liver Transplantation vs Living Donor Liver Transplantation</title><author>Zhang, R. ; Zhu, Z.-J. ; Sun, L.-Y. ; Wei, L. ; Qu, W. ; Zeng, Z.-G. ; Liu, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-cd6c07f78f71dc2a7930c1d3ef9b10d335921fd11db29313634ac04dd9e9d6993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Child</topic><topic>Female</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Liver Transplantation - methods</topic><topic>Liver Transplantation - mortality</topic><topic>Living Donors</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Complications - epidemiology</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tissue Donors - supply & distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, R.</creatorcontrib><creatorcontrib>Zhu, Z.-J.</creatorcontrib><creatorcontrib>Sun, L.-Y.</creatorcontrib><creatorcontrib>Wei, L.</creatorcontrib><creatorcontrib>Qu, W.</creatorcontrib><creatorcontrib>Zeng, Z.-G.</creatorcontrib><creatorcontrib>Liu, Y.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, R.</au><au>Zhu, Z.-J.</au><au>Sun, L.-Y.</au><au>Wei, L.</au><au>Qu, W.</au><au>Zeng, Z.-G.</au><au>Liu, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of Pediatric Liver Transplantation: Deceased Donor Liver Transplantation vs Living Donor Liver Transplantation</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2018-12</date><risdate>2018</risdate><volume>50</volume><issue>10</issue><spage>3601</spage><epage>3605</epage><pages>3601-3605</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>The use of pediatric donor liver for pediatric liver transplantation (LT) remains controversial and few studies have focused on pediatric deceased donors. To address this issue, we decided to perform a retrospective research, trying to compare the clinical effects between deceased donor LTs (DDLTs) and living donor LTs (LDLTs).
A retrospective review of pediatric LTs using grafts from deceased donors and living donors from June 2013 to August 2016 was performed. The children were divided into a DDLT group and a LDLT group based on their donor styles. The incidence of early vascular complications (VC), biliary complications, and graft and patient survival rates were observed between the 2 groups.
There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs). The 1-year cumulative survival rates of grafts and recipients were 89.16% and 91.57% in DDLTs, and 95.47% and 95.52% in LDLTs, respectively (P > .05). The incidence of early VC was lower in LDLTs than that in DDLTs (3.7% vs 19.3%, P < .001). The incidence of HAT in children aged less than 1 year was significantly higher in the DDLT group (P < .001) and can be up to 31.82%. The incidence of biliary complications was similar in the 2 groups (8.4% vs 13.5%, P = .285).
Pediatric DDLTs have similar graft and patient survival rates with LDLT. The incidence of early VC was higher in DDLTs, and children aged less than 1 year are at a higher risk of developing HAT.
•Along with considerable development of organ donation after death of people in China, pediatric donation has become an important supplement to the graft pool, which has an important role in decreasing mortality among patients on the waiting list.•This study evaluated the efficacy of pediatric liver transplantation (LT) using deceased donor whole liver and living donor liver, and compares the outcomes.•There were 217 cases of pediatric LTs performed in our hospital from June 2013 to August 2016 (83 DDLTs and 134 LDLTs).•The 1-year cumulative survival rates of grafts and recipients were 89.16%, 91.57% in DDLT, and 95.47%, 95.52% in LDLT, respectively (P > .05). The ratio of early VC was lower in LDLTs than that in DDLTs (3.73% vs 19.28%, P < .001).•The incidence of HAT in children aged less than 1 year was significantly higher among the DDLT group (P < .001), and the ratio can be up to 31.82%.•Our study showed that pediatric DDLT have a similar graft and patient survival rates with LDLT. The incidence of VC was higher in DDLT, and children aged less than 1 year are at higher risk of developing HAT.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30577244</pmid><doi>10.1016/j.transproceed.2018.04.035</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Child Female Graft Survival Humans Incidence Infant Liver Transplantation - methods Liver Transplantation - mortality Living Donors Male Middle Aged Postoperative Complications - epidemiology Retrospective Studies Survival Rate Tissue Donors - supply & distribution |
| title | Outcomes of Pediatric Liver Transplantation: Deceased Donor Liver Transplantation vs Living Donor Liver Transplantation |
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