Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas

Carcinomas originate from epithelial tissues, which have apical (luminal) and basal orientations. The degree of luminal versus basal differentiation in cancer has been shown to be biologically important in some carcinomas and impacts treatment response. Although prior studies have focused on individ...

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Veröffentlicht in:	Clinical cancer research 2019-04, Vol.25 (8), p.2450-2457
Hauptverfasser:	Zhao, Shuang G, Chen, William S, Das, Rajdeep, Chang, S Laura, Tomlins, Scott A, Chou, Jonathan, Quigley, David A, Dang, Ha X, Barnard, Travis J, Mahal, Brandon A, Gibb, Ewan A, Liu, Yang, Davicioni, Elai, Duska, Linda R, Posadas, Edwin M, Jolly, Shruti, Spratt, Daniel E, Nguyen, Paul L, Maher, Christopher A, Small, Eric J, Feng, Felix Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomarkers, Tumor Carcinoma - diagnosis Carcinoma - drug therapy Carcinoma - genetics Carcinoma, Basal Cell - diagnosis Carcinoma, Basal Cell - drug therapy Carcinoma, Basal Cell - genetics Cell Line, Tumor Computational Biology - methods Drug Resistance, Neoplasm - genetics Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Genetic Association Studies - methods Genetic Predisposition to Disease Genomics - methods Humans Kaplan-Meier Estimate Mutation Prognosis Transcriptome
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