Long noncoding RNA CRCMSL suppresses tumor invasive and metastasis in colorectal carcinoma through nucleocytoplasmic shuttling of HMGB2

Long noncoding RNAs (lncRNAs) are pervasive transcripts that play pivotal roles in regulating chromatin dynamics, gene and protein expression. Aberrant expression and mutations of lncRNAs represent a driving force behind tumor invasion and metastasis, making them attractive cancer targets. However,...

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Veröffentlicht in:	Oncogene 2019-04, Vol.38 (16), p.3019-3032
Hauptverfasser:	Han, Qinrui, Xu, Lijun, Lin, Weihao, Yao, Xueqing, Jiang, Muhong, Zhou, Rui, Sun, Xuegang, Zhao, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/89 14/63 38/39 45/15 45/61 631/67/1504/1885 631/67/322 64/60 82/58 96/95 Active Transport, Cell Nucleus - genetics Animals Antisense RNA Apoptosis Cadherins Carcinoma Cell Biology Cell Line, Tumor Cell migration Cell Movement - genetics Cell Nucleus - physiology Cell proliferation Cell Proliferation - genetics Chromatin Chromosomal proteins Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Cytoplasm Cytoplasm - physiology DNA microarrays Epithelial-Mesenchymal Transition - genetics Female Gene expression Gene Expression Regulation, Neoplastic - genetics Genes Genetic aspects HCT116 Cells High mobility group proteins HMGB2 Protein - genetics Human Genetics Humans Internal Medicine Invasiveness Leptomycin B Localization Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Nuclear transport Nucleotides Oct-4 protein Oncology Phenotypes Prognosis Protein interaction Protein Transport - genetics Proteins Ribonucleic acid RNA RNA, Long Noncoding - genetics Stem cells Tumors
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