Resveratrol treatment of spinal cord injury in rat model
Spinal cord injury (SCI) is catastrophic and can culminate in disability and death. The routine therapy employed in early stages of SCI currently entails surgical procedures combined with high doses of methylprednisolone (MP). MP is highly controversial for the lack of consensus on its true therapeu...
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| Veröffentlicht in: | Microscopy research and technique 2019-03, Vol.82 (3), p.296-303 |
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| creator | Liu, Xuehong Botchway, Benson O.A. Tan, Xiaoning Zhang, Yong Fang, Marong |
| description | Spinal cord injury (SCI) is catastrophic and can culminate in disability and death. The routine therapy employed in early stages of SCI currently entails surgical procedures combined with high doses of methylprednisolone (MP). MP is highly controversial for the lack of consensus on its true therapeutic effects. Resveratrol (RES) has recently been recognized as a potential and novel therapeutic drug in SCI. Herein, we investigated the effect of RES in a SCI rat‐model and found significant improvement in Basso–Beattie–Bresnahan scores. Results obtained from histological, immunohistochemistry, and ultra‐structural examinations evidenced the tremendous treatment effect of RES. On the basis of our experimental results, we hypothesize that RES could serve as an effective SCI therapeutic with prolong treatment time following injury.
Resveratrol (RES) is a Traditional Chinese Medicine. It did improve spinal cord injury (SCI) by inhibiting apoptosis, whiles also instigating axonal regeneration at lesion sites. RES has the potentiality of serving as future SCI therapeutic; however, further investigations regarding its mechanistic action are warranted. |
| doi_str_mv | 10.1002/jemt.23171 |
| format | Article |
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Resveratrol (RES) is a Traditional Chinese Medicine. It did improve spinal cord injury (SCI) by inhibiting apoptosis, whiles also instigating axonal regeneration at lesion sites. RES has the potentiality of serving as future SCI therapeutic; however, further investigations regarding its mechanistic action are warranted.</description><identifier>ISSN: 1059-910X</identifier><identifier>EISSN: 1097-0029</identifier><identifier>DOI: 10.1002/jemt.23171</identifier><identifier>PMID: 30575194</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; bcl-2-Associated X Protein - biosynthesis ; Caspase 3 - biosynthesis ; Disease Models, Animal ; electron microscope ; GAP-43 Protein - biosynthesis ; Immunohistochemistry ; Inflammation - drug therapy ; Inflammation - prevention & control ; Injuries ; Male ; Methylprednisolone ; Methylprednisolone - adverse effects ; Methylprednisolone - therapeutic use ; Microscopy, Electron ; Neuroprotective Agents - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Resveratrol ; Resveratrol - therapeutic use ; Spinal cord injuries ; Spinal Cord Injuries - drug therapy ; Spinal Cord Injuries - surgery ; spinal cord injury ; Surgery</subject><ispartof>Microscopy research and technique, 2019-03, Vol.82 (3), p.296-303</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3571-f99253899dabb6a823061e75461c67e8dafddc395c7a2090ef0a23b7f7ba5b343</citedby><cites>FETCH-LOGICAL-c3571-f99253899dabb6a823061e75461c67e8dafddc395c7a2090ef0a23b7f7ba5b343</cites><orcidid>0000-0001-9732-7904 ; 0000-0002-6636-4347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjemt.23171$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjemt.23171$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30575194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xuehong</creatorcontrib><creatorcontrib>Botchway, Benson O.A.</creatorcontrib><creatorcontrib>Tan, Xiaoning</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Fang, Marong</creatorcontrib><title>Resveratrol treatment of spinal cord injury in rat model</title><title>Microscopy research and technique</title><addtitle>Microsc Res Tech</addtitle><description>Spinal cord injury (SCI) is catastrophic and can culminate in disability and death. The routine therapy employed in early stages of SCI currently entails surgical procedures combined with high doses of methylprednisolone (MP). MP is highly controversial for the lack of consensus on its true therapeutic effects. Resveratrol (RES) has recently been recognized as a potential and novel therapeutic drug in SCI. Herein, we investigated the effect of RES in a SCI rat‐model and found significant improvement in Basso–Beattie–Bresnahan scores. Results obtained from histological, immunohistochemistry, and ultra‐structural examinations evidenced the tremendous treatment effect of RES. On the basis of our experimental results, we hypothesize that RES could serve as an effective SCI therapeutic with prolong treatment time following injury.
Resveratrol (RES) is a Traditional Chinese Medicine. It did improve spinal cord injury (SCI) by inhibiting apoptosis, whiles also instigating axonal regeneration at lesion sites. RES has the potentiality of serving as future SCI therapeutic; however, further investigations regarding its mechanistic action are warranted.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>bcl-2-Associated X Protein - biosynthesis</subject><subject>Caspase 3 - biosynthesis</subject><subject>Disease Models, Animal</subject><subject>electron microscope</subject><subject>GAP-43 Protein - biosynthesis</subject><subject>Immunohistochemistry</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - prevention & control</subject><subject>Injuries</subject><subject>Male</subject><subject>Methylprednisolone</subject><subject>Methylprednisolone - adverse effects</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Microscopy, Electron</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Resveratrol</subject><subject>Resveratrol - therapeutic use</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - drug therapy</subject><subject>Spinal Cord Injuries - surgery</subject><subject>spinal cord injury</subject><subject>Surgery</subject><issn>1059-910X</issn><issn>1097-0029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LxDAQBuAgiruuXvwBUvAiQjXTNE1zlGX9YkWQFbyFtJ1CS7tZk1bZf29qVw8ePM0wPLwwLyGnQK-A0ui6xra7ihgI2CNToFKE_ir3h53LUAJ9m5Aj52pKATjEh2TCKBccZDwl6Qu6D7S6s6YJOou6a3HdBaYM3KZa6ybIjS2Cal33dutH4GXQmgKbY3JQ6sbhyW7OyOvtYjW_D5fPdw_zm2WYMy4gLKWMOEulLHSWJTqNGE0ABY8TyBOBaaHLosiZ5LnQEZUUS6ojlolSZJpnLGYzcjHmbqx579F1qq1cjk2j12h6pyLgUqYMIPX0_A-tTW_9E4NKYxYlgoJXl6PKrXHOYqk2tmq13SqgauhTDX2q7z49PttF9lmLxS_9KdADGMFn1eD2nyj1uHhajaFfxl9-nA</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Liu, Xuehong</creator><creator>Botchway, Benson O.A.</creator><creator>Tan, Xiaoning</creator><creator>Zhang, Yong</creator><creator>Fang, Marong</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9732-7904</orcidid><orcidid>https://orcid.org/0000-0002-6636-4347</orcidid></search><sort><creationdate>201903</creationdate><title>Resveratrol treatment of spinal cord injury in rat model</title><author>Liu, Xuehong ; Botchway, Benson O.A. ; Tan, Xiaoning ; Zhang, Yong ; Fang, Marong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-f99253899dabb6a823061e75461c67e8dafddc395c7a2090ef0a23b7f7ba5b343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>bcl-2-Associated X Protein - biosynthesis</topic><topic>Caspase 3 - biosynthesis</topic><topic>Disease Models, Animal</topic><topic>electron microscope</topic><topic>GAP-43 Protein - biosynthesis</topic><topic>Immunohistochemistry</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - prevention & control</topic><topic>Injuries</topic><topic>Male</topic><topic>Methylprednisolone</topic><topic>Methylprednisolone - adverse effects</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Microscopy, Electron</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Resveratrol</topic><topic>Resveratrol - therapeutic use</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - drug therapy</topic><topic>Spinal Cord Injuries - surgery</topic><topic>spinal cord injury</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xuehong</creatorcontrib><creatorcontrib>Botchway, Benson O.A.</creatorcontrib><creatorcontrib>Tan, Xiaoning</creatorcontrib><creatorcontrib>Zhang, Yong</creatorcontrib><creatorcontrib>Fang, Marong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microscopy research and technique</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xuehong</au><au>Botchway, Benson O.A.</au><au>Tan, Xiaoning</au><au>Zhang, Yong</au><au>Fang, Marong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol treatment of spinal cord injury in rat model</atitle><jtitle>Microscopy research and technique</jtitle><addtitle>Microsc Res Tech</addtitle><date>2019-03</date><risdate>2019</risdate><volume>82</volume><issue>3</issue><spage>296</spage><epage>303</epage><pages>296-303</pages><issn>1059-910X</issn><eissn>1097-0029</eissn><abstract>Spinal cord injury (SCI) is catastrophic and can culminate in disability and death. The routine therapy employed in early stages of SCI currently entails surgical procedures combined with high doses of methylprednisolone (MP). MP is highly controversial for the lack of consensus on its true therapeutic effects. Resveratrol (RES) has recently been recognized as a potential and novel therapeutic drug in SCI. Herein, we investigated the effect of RES in a SCI rat‐model and found significant improvement in Basso–Beattie–Bresnahan scores. Results obtained from histological, immunohistochemistry, and ultra‐structural examinations evidenced the tremendous treatment effect of RES. On the basis of our experimental results, we hypothesize that RES could serve as an effective SCI therapeutic with prolong treatment time following injury.
Resveratrol (RES) is a Traditional Chinese Medicine. It did improve spinal cord injury (SCI) by inhibiting apoptosis, whiles also instigating axonal regeneration at lesion sites. RES has the potentiality of serving as future SCI therapeutic; however, further investigations regarding its mechanistic action are warranted.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30575194</pmid><doi>10.1002/jemt.23171</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9732-7904</orcidid><orcidid>https://orcid.org/0000-0002-6636-4347</orcidid></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use bcl-2-Associated X Protein - biosynthesis Caspase 3 - biosynthesis Disease Models, Animal electron microscope GAP-43 Protein - biosynthesis Immunohistochemistry Inflammation - drug therapy Inflammation - prevention & control Injuries Male Methylprednisolone Methylprednisolone - adverse effects Methylprednisolone - therapeutic use Microscopy, Electron Neuroprotective Agents - therapeutic use Rats Rats, Sprague-Dawley Resveratrol Resveratrol - therapeutic use Spinal cord injuries Spinal Cord Injuries - drug therapy Spinal Cord Injuries - surgery spinal cord injury Surgery |
| title | Resveratrol treatment of spinal cord injury in rat model |
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