Keratan sulfate (KS)‐proteoglycans and neuronal regulation in health and disease: the importance of KS‐glycodynamics and interactive capability with neuroregulatory ligands

Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties. In the human body, the cornea and the brain are the two most abundant tissue sources of...

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Veröffentlicht in:	Journal of neurochemistry 2019-04, Vol.149 (2), p.170-194
1. Verfasser:	Melrose, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Aggrecan Animals Binding sites Brain Central nervous system Charge density Charge distribution Chondroitin sulfate Cones Cornea Cytoskeleton Depolymerization Differentiation Disaccharides Embryos extracellular matrix and neuronal guidance Galactose Glycosaminoglycans Growth cones Guanosine triphosphatases Heparan sulfate Heparin Humans Hyaluronic acid Keratan sulfate Keratan Sulfate - metabolism keratan sulfate neural proteoglycans Ligands Microtubule-associated protein 1 neural repair neuronal plasticity Neurons - metabolism Neuroprotection Neurotransmitters Perineuronal nets Peripheral nervous system Proteins Proteoglycans Proteoglycans - metabolism Proteomics Sulfates Sulfation Synaptogenesis Trauma
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