Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality
Variation in survival of pediatric acute myeloid leukemia (pAML) over time and between Western European countries exists. The aim of the current study is to assess the progress made for the Dutch pAML population (0–17 years) during 1990–2015, based on trends in incidence, survival and mortality. Dat...
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| Veröffentlicht in: | Leukemia 2019-06, Vol.33 (6), p.1349-1359 |
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| creator | Reedijk, A. M. J. Klein, K. Coebergh, J. W. W. Kremer, L. C. Dinmohamed, A. G. de Haas, V. Versluijs, A. B. Ossenkoppele, G. J. Beverloo, H. B. Pieters, R. Zwaan, C. M. Kaspers, G. J. L. Karim-Kos, H. E. |
| description | Variation in survival of pediatric acute myeloid leukemia (pAML) over time and between Western European countries exists. The aim of the current study is to assess the progress made for the Dutch pAML population (0–17 years) during 1990–2015, based on trends in incidence, survival and mortality. Data from the population-based Netherlands Cancer Registry were merged with leukemia-related characteristics and treatment specifics from the Dutch Childhood Leukemia Study Group (Dutch Childhood Oncology Group (DCOG) from 2002 onwards). Mortality data (1980–2016) were obtained from the cause of death registry of Statistics Netherlands. Trend analyses were performed over time and by treatment protocol. Between 1990 and 2015, a total of 635 children aged 0–17 years were diagnosed with AML for an average of 25 patients (range 18–36) per year. There was a slight increase in the incidence at age 1–4 years (average annual percentage change (AAPC) of +2.2% per year (95% CI 0.8–3.5,
p
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| doi_str_mv | 10.1038/s41375-018-0314-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2159328265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2159328265</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-eff79bdcf205ef5acc17d6e3b2d9fa00b457ec42e77e4ed37bd28f8e90fcb60f3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhi0EotvCD-CCLHHh0IA_4jjhVrUFKlXiAmfLscddl8Qu_liUOz-8WW2hElJPc5hn3pnRg9AbSj5QwvuPuaVciobQviGcto18hja0lV0jhKDP0Yb0vWy6gbVH6DjnW0L2ze4lOuJEdD2VdIP-XM13Ke7A4lzTzu_0hF1M2Gz9ZBMErIPFS6zhBmsbJ8gGQsn4ty9brE0tgOcFpugtnqD-hNnrT1jji1rMFudS7YJjwD4YbyEYOH1css-dYyp68mV5hV44PWV4_VBP0I_Pl9_PvzbX375cnZ9dN4ZLVhpwTg6jNY4RAU5oY6i0HfCR2cFpQsZWSDAtAymhBcvlaFnvehiIM2NHHD9B7w-568u_KuSiZr9-NE06QKxZMSoGznrWiRV99x96G2sK63WKMS460ZN2WCl6oEyKOSdw6i75WadFUaL2itRBkVoVqb0iJdeZtw_JdZzB_pv462QF2AHIayvcQHpc_XTqPbDtn0w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2235658049</pqid></control><display><type>article</type><title>Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Reedijk, A. M. J. ; Klein, K. ; Coebergh, J. W. W. ; Kremer, L. C. ; Dinmohamed, A. G. ; de Haas, V. ; Versluijs, A. B. ; Ossenkoppele, G. J. ; Beverloo, H. B. ; Pieters, R. ; Zwaan, C. M. ; Kaspers, G. J. L. ; Karim-Kos, H. E.</creator><creatorcontrib>Reedijk, A. M. J. ; Klein, K. ; Coebergh, J. W. W. ; Kremer, L. C. ; Dinmohamed, A. G. ; de Haas, V. ; Versluijs, A. B. ; Ossenkoppele, G. J. ; Beverloo, H. B. ; Pieters, R. ; Zwaan, C. M. ; Kaspers, G. J. L. ; Karim-Kos, H. E.</creatorcontrib><description>Variation in survival of pediatric acute myeloid leukemia (pAML) over time and between Western European countries exists. The aim of the current study is to assess the progress made for the Dutch pAML population (0–17 years) during 1990–2015, based on trends in incidence, survival and mortality. Data from the population-based Netherlands Cancer Registry were merged with leukemia-related characteristics and treatment specifics from the Dutch Childhood Leukemia Study Group (Dutch Childhood Oncology Group (DCOG) from 2002 onwards). Mortality data (1980–2016) were obtained from the cause of death registry of Statistics Netherlands. Trend analyses were performed over time and by treatment protocol. Between 1990 and 2015, a total of 635 children aged 0–17 years were diagnosed with AML for an average of 25 patients (range 18–36) per year. There was a slight increase in the incidence at age 1–4 years (average annual percentage change (AAPC) of +2.2% per year (95% CI 0.8–3.5,
p
< 0.01)). Overall, the 5-year survival significantly improved over the past 26 years and nearly doubled from 40% in the early 1990s to 74% in 2010–2015. Multivariable analysis showed a 49% reduction in risk of death for pAML patients treated according to the latest DB-AML 01 protocol (
p
= 0.03). The continuing decrease of mortality (AAPC −2.8% per year (95% CI −4.1 to −1.5)) supports the conclusion of true progress against pAML in the Netherlands.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/s41375-018-0314-7</identifier><identifier>PMID: 30568171</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/2324 ; 692/308/174 ; Acute myeloid leukemia ; Adolescent ; Adolescents ; Adult ; Cancer Research ; Child ; Child, Preschool ; Children ; Critical Care Medicine ; Female ; Follow-Up Studies ; Health risk assessment ; Hematology ; Humans ; Incidence ; Infant ; Infant, Newborn ; Intensive ; Internal Medicine ; Leukemia ; Leukemia, Myeloid, Acute - epidemiology ; Leukemia, Myeloid, Acute - mortality ; Leukemia, Myeloid, Acute - pathology ; Male ; Medicine ; Medicine & Public Health ; Mortality ; Mortality - trends ; Myeloid leukemia ; Netherlands - epidemiology ; Oncology ; Patients ; Prognosis ; Registries - statistics & numerical data ; Retrospective Studies ; Statistical analysis ; Survival ; Survival Rate ; Young Adult</subject><ispartof>Leukemia, 2019-06, Vol.33 (6), p.1349-1359</ispartof><rights>Springer Nature Limited 2018</rights><rights>Copyright Nature Publishing Group Jun 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-eff79bdcf205ef5acc17d6e3b2d9fa00b457ec42e77e4ed37bd28f8e90fcb60f3</citedby><cites>FETCH-LOGICAL-c372t-eff79bdcf205ef5acc17d6e3b2d9fa00b457ec42e77e4ed37bd28f8e90fcb60f3</cites><orcidid>0000-0002-4767-6716 ; 0000-0002-9794-1071</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41375-018-0314-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41375-018-0314-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30568171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reedijk, A. M. J.</creatorcontrib><creatorcontrib>Klein, K.</creatorcontrib><creatorcontrib>Coebergh, J. W. W.</creatorcontrib><creatorcontrib>Kremer, L. C.</creatorcontrib><creatorcontrib>Dinmohamed, A. G.</creatorcontrib><creatorcontrib>de Haas, V.</creatorcontrib><creatorcontrib>Versluijs, A. B.</creatorcontrib><creatorcontrib>Ossenkoppele, G. J.</creatorcontrib><creatorcontrib>Beverloo, H. B.</creatorcontrib><creatorcontrib>Pieters, R.</creatorcontrib><creatorcontrib>Zwaan, C. M.</creatorcontrib><creatorcontrib>Kaspers, G. J. L.</creatorcontrib><creatorcontrib>Karim-Kos, H. E.</creatorcontrib><title>Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Variation in survival of pediatric acute myeloid leukemia (pAML) over time and between Western European countries exists. The aim of the current study is to assess the progress made for the Dutch pAML population (0–17 years) during 1990–2015, based on trends in incidence, survival and mortality. Data from the population-based Netherlands Cancer Registry were merged with leukemia-related characteristics and treatment specifics from the Dutch Childhood Leukemia Study Group (Dutch Childhood Oncology Group (DCOG) from 2002 onwards). Mortality data (1980–2016) were obtained from the cause of death registry of Statistics Netherlands. Trend analyses were performed over time and by treatment protocol. Between 1990 and 2015, a total of 635 children aged 0–17 years were diagnosed with AML for an average of 25 patients (range 18–36) per year. There was a slight increase in the incidence at age 1–4 years (average annual percentage change (AAPC) of +2.2% per year (95% CI 0.8–3.5,
p
< 0.01)). Overall, the 5-year survival significantly improved over the past 26 years and nearly doubled from 40% in the early 1990s to 74% in 2010–2015. Multivariable analysis showed a 49% reduction in risk of death for pAML patients treated according to the latest DB-AML 01 protocol (
p
= 0.03). The continuing decrease of mortality (AAPC −2.8% per year (95% CI −4.1 to −1.5)) supports the conclusion of true progress against pAML in the Netherlands.</description><subject>631/67/2324</subject><subject>692/308/174</subject><subject>Acute myeloid leukemia</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Cancer Research</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Critical Care Medicine</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health risk assessment</subject><subject>Hematology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid, Acute - epidemiology</subject><subject>Leukemia, Myeloid, Acute - mortality</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Mortality - trends</subject><subject>Myeloid leukemia</subject><subject>Netherlands - epidemiology</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Registries - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Young Adult</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQhi0EotvCD-CCLHHh0IA_4jjhVrUFKlXiAmfLscddl8Qu_liUOz-8WW2hElJPc5hn3pnRg9AbSj5QwvuPuaVciobQviGcto18hja0lV0jhKDP0Yb0vWy6gbVH6DjnW0L2ze4lOuJEdD2VdIP-XM13Ke7A4lzTzu_0hF1M2Gz9ZBMErIPFS6zhBmsbJ8gGQsn4ty9brE0tgOcFpugtnqD-hNnrT1jji1rMFudS7YJjwD4YbyEYOH1css-dYyp68mV5hV44PWV4_VBP0I_Pl9_PvzbX375cnZ9dN4ZLVhpwTg6jNY4RAU5oY6i0HfCR2cFpQsZWSDAtAymhBcvlaFnvehiIM2NHHD9B7w-568u_KuSiZr9-NE06QKxZMSoGznrWiRV99x96G2sK63WKMS460ZN2WCl6oEyKOSdw6i75WadFUaL2itRBkVoVqb0iJdeZtw_JdZzB_pv462QF2AHIayvcQHpc_XTqPbDtn0w</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Reedijk, A. 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M. J. ; Klein, K. ; Coebergh, J. W. W. ; Kremer, L. C. ; Dinmohamed, A. G. ; de Haas, V. ; Versluijs, A. B. ; Ossenkoppele, G. J. ; Beverloo, H. B. ; Pieters, R. ; Zwaan, C. M. ; Kaspers, G. J. L. ; Karim-Kos, H. 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M. J.</au><au>Klein, K.</au><au>Coebergh, J. W. W.</au><au>Kremer, L. C.</au><au>Dinmohamed, A. G.</au><au>de Haas, V.</au><au>Versluijs, A. B.</au><au>Ossenkoppele, G. J.</au><au>Beverloo, H. B.</au><au>Pieters, R.</au><au>Zwaan, C. M.</au><au>Kaspers, G. J. L.</au><au>Karim-Kos, H. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>33</volume><issue>6</issue><spage>1349</spage><epage>1359</epage><pages>1349-1359</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><abstract>Variation in survival of pediatric acute myeloid leukemia (pAML) over time and between Western European countries exists. The aim of the current study is to assess the progress made for the Dutch pAML population (0–17 years) during 1990–2015, based on trends in incidence, survival and mortality. Data from the population-based Netherlands Cancer Registry were merged with leukemia-related characteristics and treatment specifics from the Dutch Childhood Leukemia Study Group (Dutch Childhood Oncology Group (DCOG) from 2002 onwards). Mortality data (1980–2016) were obtained from the cause of death registry of Statistics Netherlands. Trend analyses were performed over time and by treatment protocol. Between 1990 and 2015, a total of 635 children aged 0–17 years were diagnosed with AML for an average of 25 patients (range 18–36) per year. There was a slight increase in the incidence at age 1–4 years (average annual percentage change (AAPC) of +2.2% per year (95% CI 0.8–3.5,
p
< 0.01)). Overall, the 5-year survival significantly improved over the past 26 years and nearly doubled from 40% in the early 1990s to 74% in 2010–2015. Multivariable analysis showed a 49% reduction in risk of death for pAML patients treated according to the latest DB-AML 01 protocol (
p
= 0.03). The continuing decrease of mortality (AAPC −2.8% per year (95% CI −4.1 to −1.5)) supports the conclusion of true progress against pAML in the Netherlands.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30568171</pmid><doi>10.1038/s41375-018-0314-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4767-6716</orcidid><orcidid>https://orcid.org/0000-0002-9794-1071</orcidid></addata></record> |
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| subjects | 631/67/2324 692/308/174 Acute myeloid leukemia Adolescent Adolescents Adult Cancer Research Child Child, Preschool Children Critical Care Medicine Female Follow-Up Studies Health risk assessment Hematology Humans Incidence Infant Infant, Newborn Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - epidemiology Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Male Medicine Medicine & Public Health Mortality Mortality - trends Myeloid leukemia Netherlands - epidemiology Oncology Patients Prognosis Registries - statistics & numerical data Retrospective Studies Statistical analysis Survival Survival Rate Young Adult |
| title | Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality |
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