Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway

Reported is the identification of the furo[3,2‐b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc‐like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic sequences based on c...

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Veröffentlicht in:	Angewandte Chemie International Edition 2019-01, Vol.58 (4), p.1062-1066
Hauptverfasser:	Němec, Václav, Hylsová, Michaela, Maier, Lukáš, Flegel, Jana, Sievers, Sonja, Ziegler, Slava, Schröder, Martin, Berger, Benedict‐Tilman, Chaikuad, Apirat, Valčíková, Barbora, Uldrijan, Stjepan, Drápela, Stanislav, Souček, Karel, Waldmann, Herbert, Knapp, Stefan, Paruch, Kamil
Format:	Artikel
Sprache:	eng
Schlagworte:	biological activity chemical probes Couplings Hedgehog protein heterocycles Inhibitors Kinases Lymphocytes B Modulators Optimization Pyridines Scaffolds Signal transduction
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