A novel peripheral cannabinoid 1 receptor antagonist, AJ5012, improves metabolic outcomes and suppresses adipose tissue inflammation in obese mice

ABSTRACT The overactivity of cannabinoid 1 receptor (CB1R) is associated with obesity and type 2 diabetes. First‐generation CB1R antagonists, such as rimonabant, offered therapeutic advantages for the control of obesity and related metabolic abnormalities, but their therapeutic potential was limited...

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Veröffentlicht in:The FASEB journal 2019-03, Vol.33 (3), p.4314-4326
Hauptverfasser: Han, Ji Hye, Shin, Hanho, Park, Ju-Young, Rho, Jun Gi, Son, Dong Hwee, Kim, Ki Woo, Seong, Je Kyung, Yoon, Sung-Hwa, Kim, Wook
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Sprache:eng
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