The speed of kill of a topical combination of selamectin plus sarolaner against induced infestations of Ixodes scapularis ticks on cats
•Speed of kill of selamectin plus sarolaner was evaluated against Ixodes scapularis in cats.•Selamectin plus sarolaner started to kill ticks within 12 h after treatment.•Efficacy of 100% was observed within 24 h after treatment.•The product started to kill ticks within 24 h after weekly re-infestati...
Gespeichert in:
| Veröffentlicht in: | Veterinary parasitology 2019-06, Vol.270, p.S26-S30 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S30 |
|---|---|
| container_issue | |
| container_start_page | S26 |
| container_title | Veterinary parasitology |
| container_volume | 270 |
| creator | Vatta, Adriano F. Everett, William R. Cherni, Judith A. King, Vickie L. Rugg, Douglas |
| description | •Speed of kill of selamectin plus sarolaner was evaluated against Ixodes scapularis in cats.•Selamectin plus sarolaner started to kill ticks within 12 h after treatment.•Efficacy of 100% was observed within 24 h after treatment.•The product started to kill ticks within 24 h after weekly re-infestations, for 5 weeks.•Efficacy observed at 24 h after re-infestation was >94% at 1–3 weeks and >56% at 4–5 weeks.•There were no treatment-related adverse reactions.
The speed of kill of a novel, topical product containing selamectin in combination with sarolaner (selamectin/sarolaner; Revolution® Plus/Stronghold® Plus) was evaluated against Ixodes scapularis ticks on cats. Sixteen cats were randomly allocated to a treatment group and treated topically on Day 0 with either placebo (vehicle control) or 6 mg/kg selamectin plus 1 mg/kg sarolaner. Cats were infested with approximately 50 unfed viable adult I. scapularis ticks on Days -2, 7, 14, 21, 28 and 35. Efficacy was assessed at 4, 8, 12, 24, 48 and 72 h after treatment on Day 0 and at 4, 8, 12 and 24 h after post-treatment re-infestations.
There were no adverse reactions to the topical treatment with selamectin/sarolaner. Placebo-treated cats maintained tick infestations throughout the study. Treatment with selamectin/sarolaner significantly reduced tick counts within 12 h (P |
| doi_str_mv | 10.1016/j.vetpar.2018.10.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2158564351</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304401718303534</els_id><sourcerecordid>2158564351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-9bc66252ebf2d3a74658554eb354e032d6ad710566186aad657d113fdd9708f3</originalsourceid><addsrcrecordid>eNp9UcFu1TAQtBCIPlr-ACEfueRhx7GTXpBQ1UKlSlze3drYm-JXxw62U8EX8Nt1eIUjF680OzPr3SHkHWd7zrj6eNw_Ylkg7VvGhwrtK_iC7PjQi6aVkr0kOyZY13SM92fkTc5HxljHVP-anAkmlej5sCO_D9-R5gXR0jjRB-f9VoGWuDgDnpo4jy5AcTFsjYweZjTFBbr4NdMMKXoImCjcgwu5UBfsaqqbCxPm8keYN-Xtz2ixCgwsq4fkMi3OPNRWoAZKviCvJvAZ3z7Xc3K4uT5cfW3uvn25vfp815iODaW5HI1SrWxxnForoO-UHKTscBT1YaK1CmzP63aKDwrAKtlbzsVk7WXPhkmckw8n2yXFH2v9oJ5dNui3HeKadcurn-qE5JXanagmxZwTTnpJbob0S3OmtwT0UZ8S0FsCG1rBKnv_PGEdZ7T_RH9PXgmfTgSsaz46TDobh6HezKV6WW2j-_-EJ2b1mzo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2158564351</pqid></control><display><type>article</type><title>The speed of kill of a topical combination of selamectin plus sarolaner against induced infestations of Ixodes scapularis ticks on cats</title><source>Access via ScienceDirect (Elsevier)</source><creator>Vatta, Adriano F. ; Everett, William R. ; Cherni, Judith A. ; King, Vickie L. ; Rugg, Douglas</creator><creatorcontrib>Vatta, Adriano F. ; Everett, William R. ; Cherni, Judith A. ; King, Vickie L. ; Rugg, Douglas</creatorcontrib><description>•Speed of kill of selamectin plus sarolaner was evaluated against Ixodes scapularis in cats.•Selamectin plus sarolaner started to kill ticks within 12 h after treatment.•Efficacy of 100% was observed within 24 h after treatment.•The product started to kill ticks within 24 h after weekly re-infestations, for 5 weeks.•Efficacy observed at 24 h after re-infestation was >94% at 1–3 weeks and >56% at 4–5 weeks.•There were no treatment-related adverse reactions.
The speed of kill of a novel, topical product containing selamectin in combination with sarolaner (selamectin/sarolaner; Revolution® Plus/Stronghold® Plus) was evaluated against Ixodes scapularis ticks on cats. Sixteen cats were randomly allocated to a treatment group and treated topically on Day 0 with either placebo (vehicle control) or 6 mg/kg selamectin plus 1 mg/kg sarolaner. Cats were infested with approximately 50 unfed viable adult I. scapularis ticks on Days -2, 7, 14, 21, 28 and 35. Efficacy was assessed at 4, 8, 12, 24, 48 and 72 h after treatment on Day 0 and at 4, 8, 12 and 24 h after post-treatment re-infestations.
There were no adverse reactions to the topical treatment with selamectin/sarolaner. Placebo-treated cats maintained tick infestations throughout the study. Treatment with selamectin/sarolaner significantly reduced tick counts within 12 h (P < 0.0001) and resulted in 100% efficacy by 24 h. For subsequent re-infestations, live tick counts were significantly reduced by 12 h after infestation on Day 7 (P = 0.0120) and by 24 h for Days 14–35 (P < 0.0001). At 24 h after the post-treatment re-infestations, efficacy based on geometric (arithmetic) means was ≥96.1% (94.5%) through Day 21, 75.3% (67.7%) on Day 28 and 66.4% (56.4%) on Day 35.
Thus, a single topical dose of Revolution® Plus/Stronghold® Plus at the recommended minimum dose started killing ticks within 12–24 hours after treatment and re-infestations for up to 5 weeks. High acaricidal efficacy (≥90% reduction in tick burden) was achieved within 24 h after treatment and subsequent re-infestations for at least three weeks.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/j.vetpar.2018.10.016</identifier><identifier>PMID: 30563718</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cat ; Ixodes scapularis ; Sarolaner ; Selamectin ; Speed of kill ; Ticks</subject><ispartof>Veterinary parasitology, 2019-06, Vol.270, p.S26-S30</ispartof><rights>2019 Zoetis Services LLC</rights><rights>Copyright © 2019 Zoetis Services LLC. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-9bc66252ebf2d3a74658554eb354e032d6ad710566186aad657d113fdd9708f3</citedby><cites>FETCH-LOGICAL-c408t-9bc66252ebf2d3a74658554eb354e032d6ad710566186aad657d113fdd9708f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vetpar.2018.10.016$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30563718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vatta, Adriano F.</creatorcontrib><creatorcontrib>Everett, William R.</creatorcontrib><creatorcontrib>Cherni, Judith A.</creatorcontrib><creatorcontrib>King, Vickie L.</creatorcontrib><creatorcontrib>Rugg, Douglas</creatorcontrib><title>The speed of kill of a topical combination of selamectin plus sarolaner against induced infestations of Ixodes scapularis ticks on cats</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>•Speed of kill of selamectin plus sarolaner was evaluated against Ixodes scapularis in cats.•Selamectin plus sarolaner started to kill ticks within 12 h after treatment.•Efficacy of 100% was observed within 24 h after treatment.•The product started to kill ticks within 24 h after weekly re-infestations, for 5 weeks.•Efficacy observed at 24 h after re-infestation was >94% at 1–3 weeks and >56% at 4–5 weeks.•There were no treatment-related adverse reactions.
The speed of kill of a novel, topical product containing selamectin in combination with sarolaner (selamectin/sarolaner; Revolution® Plus/Stronghold® Plus) was evaluated against Ixodes scapularis ticks on cats. Sixteen cats were randomly allocated to a treatment group and treated topically on Day 0 with either placebo (vehicle control) or 6 mg/kg selamectin plus 1 mg/kg sarolaner. Cats were infested with approximately 50 unfed viable adult I. scapularis ticks on Days -2, 7, 14, 21, 28 and 35. Efficacy was assessed at 4, 8, 12, 24, 48 and 72 h after treatment on Day 0 and at 4, 8, 12 and 24 h after post-treatment re-infestations.
There were no adverse reactions to the topical treatment with selamectin/sarolaner. Placebo-treated cats maintained tick infestations throughout the study. Treatment with selamectin/sarolaner significantly reduced tick counts within 12 h (P < 0.0001) and resulted in 100% efficacy by 24 h. For subsequent re-infestations, live tick counts were significantly reduced by 12 h after infestation on Day 7 (P = 0.0120) and by 24 h for Days 14–35 (P < 0.0001). At 24 h after the post-treatment re-infestations, efficacy based on geometric (arithmetic) means was ≥96.1% (94.5%) through Day 21, 75.3% (67.7%) on Day 28 and 66.4% (56.4%) on Day 35.
Thus, a single topical dose of Revolution® Plus/Stronghold® Plus at the recommended minimum dose started killing ticks within 12–24 hours after treatment and re-infestations for up to 5 weeks. High acaricidal efficacy (≥90% reduction in tick burden) was achieved within 24 h after treatment and subsequent re-infestations for at least three weeks.</description><subject>Cat</subject><subject>Ixodes scapularis</subject><subject>Sarolaner</subject><subject>Selamectin</subject><subject>Speed of kill</subject><subject>Ticks</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9UcFu1TAQtBCIPlr-ACEfueRhx7GTXpBQ1UKlSlze3drYm-JXxw62U8EX8Nt1eIUjF680OzPr3SHkHWd7zrj6eNw_Ylkg7VvGhwrtK_iC7PjQi6aVkr0kOyZY13SM92fkTc5HxljHVP-anAkmlej5sCO_D9-R5gXR0jjRB-f9VoGWuDgDnpo4jy5AcTFsjYweZjTFBbr4NdMMKXoImCjcgwu5UBfsaqqbCxPm8keYN-Xtz2ixCgwsq4fkMi3OPNRWoAZKviCvJvAZ3z7Xc3K4uT5cfW3uvn25vfp815iODaW5HI1SrWxxnForoO-UHKTscBT1YaK1CmzP63aKDwrAKtlbzsVk7WXPhkmckw8n2yXFH2v9oJ5dNui3HeKadcurn-qE5JXanagmxZwTTnpJbob0S3OmtwT0UZ8S0FsCG1rBKnv_PGEdZ7T_RH9PXgmfTgSsaz46TDobh6HezKV6WW2j-_-EJ2b1mzo</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Vatta, Adriano F.</creator><creator>Everett, William R.</creator><creator>Cherni, Judith A.</creator><creator>King, Vickie L.</creator><creator>Rugg, Douglas</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>The speed of kill of a topical combination of selamectin plus sarolaner against induced infestations of Ixodes scapularis ticks on cats</title><author>Vatta, Adriano F. ; Everett, William R. ; Cherni, Judith A. ; King, Vickie L. ; Rugg, Douglas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-9bc66252ebf2d3a74658554eb354e032d6ad710566186aad657d113fdd9708f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cat</topic><topic>Ixodes scapularis</topic><topic>Sarolaner</topic><topic>Selamectin</topic><topic>Speed of kill</topic><topic>Ticks</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vatta, Adriano F.</creatorcontrib><creatorcontrib>Everett, William R.</creatorcontrib><creatorcontrib>Cherni, Judith A.</creatorcontrib><creatorcontrib>King, Vickie L.</creatorcontrib><creatorcontrib>Rugg, Douglas</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vatta, Adriano F.</au><au>Everett, William R.</au><au>Cherni, Judith A.</au><au>King, Vickie L.</au><au>Rugg, Douglas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The speed of kill of a topical combination of selamectin plus sarolaner against induced infestations of Ixodes scapularis ticks on cats</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>270</volume><spage>S26</spage><epage>S30</epage><pages>S26-S30</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>•Speed of kill of selamectin plus sarolaner was evaluated against Ixodes scapularis in cats.•Selamectin plus sarolaner started to kill ticks within 12 h after treatment.•Efficacy of 100% was observed within 24 h after treatment.•The product started to kill ticks within 24 h after weekly re-infestations, for 5 weeks.•Efficacy observed at 24 h after re-infestation was >94% at 1–3 weeks and >56% at 4–5 weeks.•There were no treatment-related adverse reactions.
The speed of kill of a novel, topical product containing selamectin in combination with sarolaner (selamectin/sarolaner; Revolution® Plus/Stronghold® Plus) was evaluated against Ixodes scapularis ticks on cats. Sixteen cats were randomly allocated to a treatment group and treated topically on Day 0 with either placebo (vehicle control) or 6 mg/kg selamectin plus 1 mg/kg sarolaner. Cats were infested with approximately 50 unfed viable adult I. scapularis ticks on Days -2, 7, 14, 21, 28 and 35. Efficacy was assessed at 4, 8, 12, 24, 48 and 72 h after treatment on Day 0 and at 4, 8, 12 and 24 h after post-treatment re-infestations.
There were no adverse reactions to the topical treatment with selamectin/sarolaner. Placebo-treated cats maintained tick infestations throughout the study. Treatment with selamectin/sarolaner significantly reduced tick counts within 12 h (P < 0.0001) and resulted in 100% efficacy by 24 h. For subsequent re-infestations, live tick counts were significantly reduced by 12 h after infestation on Day 7 (P = 0.0120) and by 24 h for Days 14–35 (P < 0.0001). At 24 h after the post-treatment re-infestations, efficacy based on geometric (arithmetic) means was ≥96.1% (94.5%) through Day 21, 75.3% (67.7%) on Day 28 and 66.4% (56.4%) on Day 35.
Thus, a single topical dose of Revolution® Plus/Stronghold® Plus at the recommended minimum dose started killing ticks within 12–24 hours after treatment and re-infestations for up to 5 weeks. High acaricidal efficacy (≥90% reduction in tick burden) was achieved within 24 h after treatment and subsequent re-infestations for at least three weeks.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30563718</pmid><doi>10.1016/j.vetpar.2018.10.016</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-4017 |
| ispartof | Veterinary parasitology, 2019-06, Vol.270, p.S26-S30 |
| issn | 0304-4017 1873-2550 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2158564351 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Cat Ixodes scapularis Sarolaner Selamectin Speed of kill Ticks |
| title | The speed of kill of a topical combination of selamectin plus sarolaner against induced infestations of Ixodes scapularis ticks on cats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T18%3A35%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20speed%20of%20kill%20of%20a%20topical%20combination%20of%20selamectin%20plus%20sarolaner%20against%20induced%20infestations%20of%20Ixodes%20scapularis%20ticks%20on%20cats&rft.jtitle=Veterinary%20parasitology&rft.au=Vatta,%20Adriano%20F.&rft.date=2019-06-01&rft.volume=270&rft.spage=S26&rft.epage=S30&rft.pages=S26-S30&rft.issn=0304-4017&rft.eissn=1873-2550&rft_id=info:doi/10.1016/j.vetpar.2018.10.016&rft_dat=%3Cproquest_cross%3E2158564351%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2158564351&rft_id=info:pmid/30563718&rft_els_id=S0304401718303534&rfr_iscdi=true |