Cell quiescence correlates with enhanced glioblastoma cell invasion and cytotoxic resistance

Glioblastoma (GBM) tumor cells exhibit drug resistance and are highly infiltrative. GBM stem cells (GSCs), which have low proliferative capacity are thought to be one of the sources of resistant cells which result in relapse/recurrence. However, the molecular mechanisms regulating quiescent-specific...

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Veröffentlicht in:	Experimental cell research 2019-01, Vol.374 (2), p.353-364
Hauptverfasser:	Atkins, Ryan J., Stylli, Stanley S., Kurganovs, Natalie, Mangiola, Stefano, Nowell, Cameron J., Ware, Thomas M., Corcoran, Niall M., Brown, Daniel V., Kaye, Andrew H., Morokoff, Andrew, Luwor, Rodney B., Hovens, Christopher M., Mantamadiotis, Theo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cancer stem cells Cell Division - drug effects Cell Division - physiology Cell Line, Tumor Cell Movement - drug effects Cell Movement - physiology Cell Proliferation - drug effects Cell Proliferation - physiology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - physiology Female GBM Gene expression Gene Expression Regulation, Neoplastic - drug effects Glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Humans Invasion Mice Mice, Inbred BALB C Migration Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Oregon green Proliferation Quiescence Resistance Temozolomide - pharmacology Xenograft Model Antitumor Assays - methods
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