Effects of prenatal sex hormones on behavioral sexual dimorphism
Background We investigated the association between the hormone environment during the prenatal period using cord blood, and gender‐role play behavior in school‐aged children. Methods A total of 879 school‐aged children (433 boys and 446 girls) in a prospective birth cohort study in Hokkaido were enr...
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| Veröffentlicht in: | Pediatrics international 2019-02, Vol.61 (2), p.140-146 |
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| creator | Mitsui, Takahiko Araki, Atsuko Miyashita, Chihiro Ito, Sachiko Ikeno, Tamiko Sasaki, Seiko Kitta, Takeya Moriya, Kimihiko Cho, Kazutoshi Morioka, Keita Kishi, Reiko Shinohara, Nobuo Takeda, Masayuki Nonomura, Katsuya |
| description | Background
We investigated the association between the hormone environment during the prenatal period using cord blood, and gender‐role play behavior in school‐aged children.
Methods
A total of 879 school‐aged children (433 boys and 446 girls) in a prospective birth cohort study in Hokkaido were enrolled to analyze the relationship between cord blood level of the sex hormones estradiol (E), testosterone (T), progesterone (P), and dehydroepiandrosterone (DHEA), and the Pre‐School Activities Inventory (PSAI) score. The PSAI evaluated sex‐typical characteristics, the type of preferred toys and play activities. The PSAI consists of 12 masculine and 12 feminine items, and the composite scores were calculated by subtracting the feminine score from the masculine score. Higher scores indicated male‐typical behavior.
Results
Composite and masculine PSAI scores were significantly higher in boys. Meanwhile, the feminine score was significantly lower in boys. Although T and P were significantly higher in boys, E/T was significantly higher in girls. In a multivariate regression model, including covariates of social factors, there was no correlation between any of the hormones and PSAI score in boys. In girls, only P and E/T were positively correlated with the feminine score.
Conclusions
Prenatal sex hormone exposure may influence the dimorphic brain development and behavior in school‐aged girls. Furthermore, the cord blood hormone levels may not fully reflect the hormone environment during the prenatal period. |
| doi_str_mv | 10.1111/ped.13756 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2158558133</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2158558133</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4436-1a919ff96bbf1d4976697ac55f635ae64c2ab0ddef7a121b15fce52601a867823</originalsourceid><addsrcrecordid>eNp10E1LwzAYB_AgipvTg19ACl70UJf3pDdlzhcY6EHBW0jbhHW0TU1Wdd_eaLeLYC5PyPPjT_gDcIrgFYpn2pnyChHB-B4YI0pxiiF82493gmUqIRcjcBTCCkIohaSHYEQg40xCOAbXc2tNsQ6Js0nnTavXuk6C-UqWzjeuNXHRJrlZ6o_K-WHVx1FWjfPdsgrNMTiwug7mZDsn4PVu_jJ7SBdP94-zm0VaUEp4inSGMmsznucWlTQTnGdCF4xZTpg2nBZY57AsjRUaYZQjZgvDMIdISy4kJhNwMeR23r33JqxVU4XC1LVujeuDwohJxiQiJNLzP3Tlet_G30UlWZZhSEVUl4MqvAvBG6s6XzXabxSC6qdWFWtVv7VGe7ZN7PMmvu7krscIpgP4rGqz-T9JPc9vh8hvi-6ANw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2185992047</pqid></control><display><type>article</type><title>Effects of prenatal sex hormones on behavioral sexual dimorphism</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Mitsui, Takahiko ; Araki, Atsuko ; Miyashita, Chihiro ; Ito, Sachiko ; Ikeno, Tamiko ; Sasaki, Seiko ; Kitta, Takeya ; Moriya, Kimihiko ; Cho, Kazutoshi ; Morioka, Keita ; Kishi, Reiko ; Shinohara, Nobuo ; Takeda, Masayuki ; Nonomura, Katsuya</creator><creatorcontrib>Mitsui, Takahiko ; Araki, Atsuko ; Miyashita, Chihiro ; Ito, Sachiko ; Ikeno, Tamiko ; Sasaki, Seiko ; Kitta, Takeya ; Moriya, Kimihiko ; Cho, Kazutoshi ; Morioka, Keita ; Kishi, Reiko ; Shinohara, Nobuo ; Takeda, Masayuki ; Nonomura, Katsuya</creatorcontrib><description>Background
We investigated the association between the hormone environment during the prenatal period using cord blood, and gender‐role play behavior in school‐aged children.
Methods
A total of 879 school‐aged children (433 boys and 446 girls) in a prospective birth cohort study in Hokkaido were enrolled to analyze the relationship between cord blood level of the sex hormones estradiol (E), testosterone (T), progesterone (P), and dehydroepiandrosterone (DHEA), and the Pre‐School Activities Inventory (PSAI) score. The PSAI evaluated sex‐typical characteristics, the type of preferred toys and play activities. The PSAI consists of 12 masculine and 12 feminine items, and the composite scores were calculated by subtracting the feminine score from the masculine score. Higher scores indicated male‐typical behavior.
Results
Composite and masculine PSAI scores were significantly higher in boys. Meanwhile, the feminine score was significantly lower in boys. Although T and P were significantly higher in boys, E/T was significantly higher in girls. In a multivariate regression model, including covariates of social factors, there was no correlation between any of the hormones and PSAI score in boys. In girls, only P and E/T were positively correlated with the feminine score.
Conclusions
Prenatal sex hormone exposure may influence the dimorphic brain development and behavior in school‐aged girls. Furthermore, the cord blood hormone levels may not fully reflect the hormone environment during the prenatal period.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.13756</identifier><identifier>PMID: 30565800</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>17β-Estradiol ; behavior ; Biomarkers - blood ; Child ; Child Behavior - physiology ; Child Behavior - psychology ; Children ; Children & youth ; Cord blood ; Dehydroepiandrosterone ; development ; dimorphic ; Dimorphism ; Female ; Fetal Blood - metabolism ; Gender ; Gender Identity ; Gonadal Steroid Hormones - blood ; hormone ; Hormones ; Humans ; Male ; Pediatrics ; Play and Playthings - psychology ; Pregnancy ; prenatal ; Prenatal experience ; Prenatal Exposure Delayed Effects - blood ; Prenatal Exposure Delayed Effects - psychology ; Progesterone ; Prospective Studies ; Sex ; Sex hormones ; Sex roles ; Sexual behavior ; Sexual dimorphism ; Testosterone ; Toys</subject><ispartof>Pediatrics international, 2019-02, Vol.61 (2), p.140-146</ispartof><rights>2018 Japan Pediatric Society</rights><rights>2018 Japan Pediatric Society.</rights><rights>2019 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-1a919ff96bbf1d4976697ac55f635ae64c2ab0ddef7a121b15fce52601a867823</citedby><cites>FETCH-LOGICAL-c4436-1a919ff96bbf1d4976697ac55f635ae64c2ab0ddef7a121b15fce52601a867823</cites><orcidid>0000-0003-0408-3678</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.13756$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.13756$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30565800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitsui, Takahiko</creatorcontrib><creatorcontrib>Araki, Atsuko</creatorcontrib><creatorcontrib>Miyashita, Chihiro</creatorcontrib><creatorcontrib>Ito, Sachiko</creatorcontrib><creatorcontrib>Ikeno, Tamiko</creatorcontrib><creatorcontrib>Sasaki, Seiko</creatorcontrib><creatorcontrib>Kitta, Takeya</creatorcontrib><creatorcontrib>Moriya, Kimihiko</creatorcontrib><creatorcontrib>Cho, Kazutoshi</creatorcontrib><creatorcontrib>Morioka, Keita</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><creatorcontrib>Shinohara, Nobuo</creatorcontrib><creatorcontrib>Takeda, Masayuki</creatorcontrib><creatorcontrib>Nonomura, Katsuya</creatorcontrib><title>Effects of prenatal sex hormones on behavioral sexual dimorphism</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background
We investigated the association between the hormone environment during the prenatal period using cord blood, and gender‐role play behavior in school‐aged children.
Methods
A total of 879 school‐aged children (433 boys and 446 girls) in a prospective birth cohort study in Hokkaido were enrolled to analyze the relationship between cord blood level of the sex hormones estradiol (E), testosterone (T), progesterone (P), and dehydroepiandrosterone (DHEA), and the Pre‐School Activities Inventory (PSAI) score. The PSAI evaluated sex‐typical characteristics, the type of preferred toys and play activities. The PSAI consists of 12 masculine and 12 feminine items, and the composite scores were calculated by subtracting the feminine score from the masculine score. Higher scores indicated male‐typical behavior.
Results
Composite and masculine PSAI scores were significantly higher in boys. Meanwhile, the feminine score was significantly lower in boys. Although T and P were significantly higher in boys, E/T was significantly higher in girls. In a multivariate regression model, including covariates of social factors, there was no correlation between any of the hormones and PSAI score in boys. In girls, only P and E/T were positively correlated with the feminine score.
Conclusions
Prenatal sex hormone exposure may influence the dimorphic brain development and behavior in school‐aged girls. Furthermore, the cord blood hormone levels may not fully reflect the hormone environment during the prenatal period.</description><subject>17β-Estradiol</subject><subject>behavior</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Child Behavior - physiology</subject><subject>Child Behavior - psychology</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cord blood</subject><subject>Dehydroepiandrosterone</subject><subject>development</subject><subject>dimorphic</subject><subject>Dimorphism</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Gender</subject><subject>Gender Identity</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>hormone</subject><subject>Hormones</subject><subject>Humans</subject><subject>Male</subject><subject>Pediatrics</subject><subject>Play and Playthings - psychology</subject><subject>Pregnancy</subject><subject>prenatal</subject><subject>Prenatal experience</subject><subject>Prenatal Exposure Delayed Effects - blood</subject><subject>Prenatal Exposure Delayed Effects - psychology</subject><subject>Progesterone</subject><subject>Prospective Studies</subject><subject>Sex</subject><subject>Sex hormones</subject><subject>Sex roles</subject><subject>Sexual behavior</subject><subject>Sexual dimorphism</subject><subject>Testosterone</subject><subject>Toys</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAYB_AgipvTg19ACl70UJf3pDdlzhcY6EHBW0jbhHW0TU1Wdd_eaLeLYC5PyPPjT_gDcIrgFYpn2pnyChHB-B4YI0pxiiF82493gmUqIRcjcBTCCkIohaSHYEQg40xCOAbXc2tNsQ6Js0nnTavXuk6C-UqWzjeuNXHRJrlZ6o_K-WHVx1FWjfPdsgrNMTiwug7mZDsn4PVu_jJ7SBdP94-zm0VaUEp4inSGMmsznucWlTQTnGdCF4xZTpg2nBZY57AsjRUaYZQjZgvDMIdISy4kJhNwMeR23r33JqxVU4XC1LVujeuDwohJxiQiJNLzP3Tlet_G30UlWZZhSEVUl4MqvAvBG6s6XzXabxSC6qdWFWtVv7VGe7ZN7PMmvu7krscIpgP4rGqz-T9JPc9vh8hvi-6ANw</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Mitsui, Takahiko</creator><creator>Araki, Atsuko</creator><creator>Miyashita, Chihiro</creator><creator>Ito, Sachiko</creator><creator>Ikeno, Tamiko</creator><creator>Sasaki, Seiko</creator><creator>Kitta, Takeya</creator><creator>Moriya, Kimihiko</creator><creator>Cho, Kazutoshi</creator><creator>Morioka, Keita</creator><creator>Kishi, Reiko</creator><creator>Shinohara, Nobuo</creator><creator>Takeda, Masayuki</creator><creator>Nonomura, Katsuya</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0408-3678</orcidid></search><sort><creationdate>201902</creationdate><title>Effects of prenatal sex hormones on behavioral sexual dimorphism</title><author>Mitsui, Takahiko ; Araki, Atsuko ; Miyashita, Chihiro ; Ito, Sachiko ; Ikeno, Tamiko ; Sasaki, Seiko ; Kitta, Takeya ; Moriya, Kimihiko ; Cho, Kazutoshi ; Morioka, Keita ; Kishi, Reiko ; Shinohara, Nobuo ; Takeda, Masayuki ; Nonomura, Katsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-1a919ff96bbf1d4976697ac55f635ae64c2ab0ddef7a121b15fce52601a867823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>17β-Estradiol</topic><topic>behavior</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Child Behavior - physiology</topic><topic>Child Behavior - psychology</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cord blood</topic><topic>Dehydroepiandrosterone</topic><topic>development</topic><topic>dimorphic</topic><topic>Dimorphism</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Gender</topic><topic>Gender Identity</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>hormone</topic><topic>Hormones</topic><topic>Humans</topic><topic>Male</topic><topic>Pediatrics</topic><topic>Play and Playthings - psychology</topic><topic>Pregnancy</topic><topic>prenatal</topic><topic>Prenatal experience</topic><topic>Prenatal Exposure Delayed Effects - blood</topic><topic>Prenatal Exposure Delayed Effects - psychology</topic><topic>Progesterone</topic><topic>Prospective Studies</topic><topic>Sex</topic><topic>Sex hormones</topic><topic>Sex roles</topic><topic>Sexual behavior</topic><topic>Sexual dimorphism</topic><topic>Testosterone</topic><topic>Toys</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitsui, Takahiko</creatorcontrib><creatorcontrib>Araki, Atsuko</creatorcontrib><creatorcontrib>Miyashita, Chihiro</creatorcontrib><creatorcontrib>Ito, Sachiko</creatorcontrib><creatorcontrib>Ikeno, Tamiko</creatorcontrib><creatorcontrib>Sasaki, Seiko</creatorcontrib><creatorcontrib>Kitta, Takeya</creatorcontrib><creatorcontrib>Moriya, Kimihiko</creatorcontrib><creatorcontrib>Cho, Kazutoshi</creatorcontrib><creatorcontrib>Morioka, Keita</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><creatorcontrib>Shinohara, Nobuo</creatorcontrib><creatorcontrib>Takeda, Masayuki</creatorcontrib><creatorcontrib>Nonomura, Katsuya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitsui, Takahiko</au><au>Araki, Atsuko</au><au>Miyashita, Chihiro</au><au>Ito, Sachiko</au><au>Ikeno, Tamiko</au><au>Sasaki, Seiko</au><au>Kitta, Takeya</au><au>Moriya, Kimihiko</au><au>Cho, Kazutoshi</au><au>Morioka, Keita</au><au>Kishi, Reiko</au><au>Shinohara, Nobuo</au><au>Takeda, Masayuki</au><au>Nonomura, Katsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of prenatal sex hormones on behavioral sexual dimorphism</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2019-02</date><risdate>2019</risdate><volume>61</volume><issue>2</issue><spage>140</spage><epage>146</epage><pages>140-146</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
We investigated the association between the hormone environment during the prenatal period using cord blood, and gender‐role play behavior in school‐aged children.
Methods
A total of 879 school‐aged children (433 boys and 446 girls) in a prospective birth cohort study in Hokkaido were enrolled to analyze the relationship between cord blood level of the sex hormones estradiol (E), testosterone (T), progesterone (P), and dehydroepiandrosterone (DHEA), and the Pre‐School Activities Inventory (PSAI) score. The PSAI evaluated sex‐typical characteristics, the type of preferred toys and play activities. The PSAI consists of 12 masculine and 12 feminine items, and the composite scores were calculated by subtracting the feminine score from the masculine score. Higher scores indicated male‐typical behavior.
Results
Composite and masculine PSAI scores were significantly higher in boys. Meanwhile, the feminine score was significantly lower in boys. Although T and P were significantly higher in boys, E/T was significantly higher in girls. In a multivariate regression model, including covariates of social factors, there was no correlation between any of the hormones and PSAI score in boys. In girls, only P and E/T were positively correlated with the feminine score.
Conclusions
Prenatal sex hormone exposure may influence the dimorphic brain development and behavior in school‐aged girls. Furthermore, the cord blood hormone levels may not fully reflect the hormone environment during the prenatal period.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>30565800</pmid><doi>10.1111/ped.13756</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0408-3678</orcidid></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | 17β-Estradiol behavior Biomarkers - blood Child Child Behavior - physiology Child Behavior - psychology Children Children & youth Cord blood Dehydroepiandrosterone development dimorphic Dimorphism Female Fetal Blood - metabolism Gender Gender Identity Gonadal Steroid Hormones - blood hormone Hormones Humans Male Pediatrics Play and Playthings - psychology Pregnancy prenatal Prenatal experience Prenatal Exposure Delayed Effects - blood Prenatal Exposure Delayed Effects - psychology Progesterone Prospective Studies Sex Sex hormones Sex roles Sexual behavior Sexual dimorphism Testosterone Toys |
| title | Effects of prenatal sex hormones on behavioral sexual dimorphism |
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