Comparative pharmacokinetics of major bioactive components from Puerariae Radix-Gastrodiae Rhizome extracts and their intestinal absorption in rats

Puerariae Radix (PR) and Gastrodiae Rhizome (GR) is frequently used in traditional herbal formulas to treat cardio-cerebral vascular diseases due to their synergistic effects. In this study, to elucidate the action mechanism of PR-GR in vivo, a simple and reliable ultra-performance liquid chromatogr...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2019-01, Vol.1105, p.38-46
Hauptverfasser:	Liu, Chang-Shun, Liang, Xiao, Wei, Xiao-Han, Chen, Fei-Long, Tang, Qing-Fa, Tan, Xiao-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, High Pressure Liquid - methods Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacokinetics Gastrodia - chemistry Gastrodiae Rhizome Ileum - metabolism Intestinal absorption Intestinal Absorption - physiology Isoflavones - analysis Isoflavones - pharmacokinetics Limit of Detection Linear Models Pharmacokinetics Pueraria - chemistry Puerariae Radix Rats Reproducibility of Results Tandem Mass Spectrometry - methods UPLC-MS/MS
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